[2+2]-Photocycloaddition of N‑Benzylmaleimide to Alkenes As an Approach to Functional 3‑Azabicyclo[3.2.0]heptanes
A one-step synthesis of functionalized 3-azabicyclo[3.2.0]heptanes by [2+2]-photochemical intermolecular cycloaddition of N-benzylmaleimide to alkenes was elaborated. The obtained compounds were easily transformed into the bi- and tricyclic analogues of piperidine, morpholine, piperazine, and GABA,...
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| Veröffentlicht in: | Journal of organic chemistry 2018-06, Vol.83 (12), p.6275-6289 |
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| Sprache: | eng |
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| container_end_page | 6289 |
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| container_issue | 12 |
| container_start_page | 6275 |
| container_title | Journal of organic chemistry |
| container_volume | 83 |
| creator | Skalenko, Yevhen A Druzhenko, Tetiana V Denisenko, Aleksandr V Samoilenko, Maryna V Dacenko, Oleksandr P Trofymchuk, Serhii A Grygorenko, Oleksandr O Tolmachev, Andrey A Mykhailiuk, Pavel K |
| description | A one-step synthesis of functionalized 3-azabicyclo[3.2.0]heptanes by [2+2]-photochemical intermolecular cycloaddition of N-benzylmaleimide to alkenes was elaborated. The obtained compounds were easily transformed into the bi- and tricyclic analogues of piperidine, morpholine, piperazine, and GABA, which are advanced building blocks for drug discovery. |
| doi_str_mv | 10.1021/acs.joc.8b00077 |
| format | Article |
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| ispartof | Journal of organic chemistry, 2018-06, Vol.83 (12), p.6275-6289 |
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| language | eng |
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| source | ACS Publications |
| title | [2+2]-Photocycloaddition of N‑Benzylmaleimide to Alkenes As an Approach to Functional 3‑Azabicyclo[3.2.0]heptanes |
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