A simple blood microdialysis in freely-moving rats for pharmacokinetic–pharmacodynamic modeling study of Shengmai injection with simultaneous determination of drug concentrations and efficacy levels in dialysate

[Display omitted] •A simple blood microdialysis system in freely-moving rats was established.•Simultaneous determination of drug concentrations and efficacy levels in dialysate for the PK-PD modeling study.•A LC–MS/MS method was developed to simultaneously determine seven components of Shengmai inje...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2018-05, Vol.154, p.23-30
Hauptverfasser:	Zhan, Shuyu, Ding, Baoyue, Ruan, Yu-er, Huang, Xuan, Liu, Guoqiang, Lv, Xiaoqing, Huang, Xiong, Li, Mingjuan, Jiang, Ninghua, Shao, Qing
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood microdialysis LC–MS/MS Nitric oxide Pharmacodynamics Pharmacokinetics Shengmai injection
Online-Zugang:	Volltext
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