Aneugenic potential of the nitrogen mustard analogues melphalan, chlorambucil and p- N, N-bis(2-chloroethyl)aminophenylacetic acid in cell cultures in vitro

Melphalan (MEL), chlorambucil (CAB) and p-N, N-bis(2-chloroethyl)aminophenylacetic acid (PHE) are nitrogen mustard analogues, which are clinically used as chemotherapeutic agents. They also exert carcinogenic activity. The aim of this study was to investigate the aneugenic potential of the above dru...

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Veröffentlicht in:	Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis 2007-04, Vol.617 (1), p.125-137
Hauptverfasser:	Efthimiou, M., Andrianopoulos, C., Stephanou, G., Demopoulos, N.A., Nikolaropoulos, S.S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormal centrosome number Adult Aneugens - pharmacology Aneuploidy Animals Antineoplastic Agents, Alkylating - pharmacology Azasteroids - pharmacology Cells, Cultured - drug effects Centromere Chlorambucil - pharmacology Chromosome Aberrations Chromosome malsegregation Female Humans In Situ Hybridization, Fluorescence In Vitro Techniques Lymphocytes - drug effects Male Melphalan - pharmacology Mice Micronuclei, Chromosome-Defective Micronucleus Tests Nitrogen mustard analogues Nondisjunction, Genetic Phenylacetates - chemistry Phenylacetates - pharmacology
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