Anti-inflammatory effects of a fluorovinyloxyacetamide compound KT-15087 in microglia cells

The microglial activation plays an important role in the progression of neurodegenerative diseases by secreting various proinflammatory cytokines and neurotoxic factors. Inhibition of microglial activation may alleviate neurodegenerative processes. To search for novel therapeutic agents against neur...

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Veröffentlicht in:	Pharmacological research 2009-06, Vol.59 (6), p.414-422
Hauptverfasser:	Ock, Jiyeon, Kim, Sangseop, Suk, Kyoungho
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetamides - pharmacology Animals Anti-Inflammatory Agents - pharmacology Blotting, Western Cell Line, Tumor Cell Survival - drug effects Coculture Techniques Fluorovinyloxyacetamide compounds JNK Mitogen-Activated Protein Kinases - metabolism Lipopolysaccharides - pharmacology Mice Microglia Microglia - drug effects Microglia - metabolism Neurodegenerative disease Neuroinflammation Neuroprotection Neuroprotective Agents - pharmacology NF-kappa B - antagonists & inhibitors Nitric Oxide - biosynthesis Nitric Oxide Synthase Type II - antagonists & inhibitors Nitric Oxide Synthase Type II - biosynthesis p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors Reverse Transcriptase Polymerase Chain Reaction Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - biosynthesis Vinyl Compounds - pharmacology
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