Lack of association between FTO gene variations and metabolic healthy obese (MHO) phenotype: Tehran Cardio-metabolic Genetic Study (TCGS)
Background Obesity is currently an international epidemic and metabolic derangements pose these individuals at greater risk for future morbidity and mortality. Genetics and environmental factors have undeniable effects and among genetic risk factors, FTO/CETP genes are important. The current study e...
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| Veröffentlicht in: | Eating and weight disorders 2020-02, Vol.25 (1), p.25-35 |
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| creator | Sedaghati-khayat, Bahareh Barzin, Maryam Akbarzadeh, Mahdi Guity, Kamran Fallah, Mohammad-Sadegh Pourhassan, Hoda Azizi, Fereidoun Daneshpour, Maryam S. |
| description | Background
Obesity is currently an international epidemic and metabolic derangements pose these individuals at greater risk for future morbidity and mortality. Genetics and environmental factors have undeniable effects and among genetic risk factors, FTO/CETP genes are important. The current study examines the interaction between obesity phenotypes and FTO/CETP SNPs and their effects on lipid profile changes.
Materials and methods
We selected 954 adult subjects from TCGS (47.9% male). Participants were stratified according to their BMI and presence of metabolic syndrome according to the Joint Interim Statement (JIS) definition. Nine selected polymorphisms from FTO/CETP genes were genotyped using Tetra ARMS-PCR method. After age and sex adjustment the interaction of 9 markers with lipid profiles among phenotypes were tested by PASW.
Results
In three main groups, HDL_C level had a strong significant association with CETP markers: (rs3764261,
β
(95% CI) − 0.48(− 0.61 to − 0.35),
P
= 1.0 × 10
−11
), (rs1800775,
β
(95% CI) 0.5(0.36;0.65),
P
= 1.0 × 10
−6
) and (rs1864163,
β
(95% CI) 0.3(0.16;0.43),
P
= 9.1 × 10
−5
). This association was also seen in rs7202116 within the total population. In only unhealthy metabolic obese (MUHO) subgroups four new FTO markers (rs1421085, rs1121980, rs1558902 and rs8050136) (
P
value |
| doi_str_mv | 10.1007/s40519-018-0493-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2013105706</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2013105706</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-b4181d93b165c4c933fefe24c447284e7833c013f22708f42edab13e0d48e0fb3</originalsourceid><addsrcrecordid>eNp1kc1O3DAURi3UCijlAbqpLLEZFinXP5kk7NCoDJUGzYLp2nKcGyY0Yw-2A5pH6FvXo0CpkLq6lu75Pl_pEPKFwTcGUFwECTmrMmBlBrISGT8gxyyvIGN8yj_88z4in0J4AJBMCDgkR7zKeV5xOCa_F9r8oq6lOgRnOh07Z2mN8RnR0uvVkt6jRfqk_bgKVNuGbjDq2vWdoWvUfVzvqKsxIJ3c3izP6XaN1sXdFi_pCtdeWzrTvulc9habp9KY5l0cmh2drGbzu_PP5GOr-4CnL_OE_Lz-vprdZIvl_MfsapEZUfCY1ZKVrKlEzaa5kaYSosUWuTRSFryUWJRCGGCi5byAspUcG10zgdDIEqGtxQmZjL1b7x4HDFFtumCw77VFNwTFU5hBXsA0oWfv0Ac3eJuuU1zkIAA48ESxkTLeheCxVVvfbbTfKQZq70mNnlTypPae1D7z9aV5qDfY_E28ikkAH4GQVvYe_dvX_2_9A_pdnDY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2350300202</pqid></control><display><type>article</type><title>Lack of association between FTO gene variations and metabolic healthy obese (MHO) phenotype: Tehran Cardio-metabolic Genetic Study (TCGS)</title><source>SpringerLink Journals</source><creator>Sedaghati-khayat, Bahareh ; Barzin, Maryam ; Akbarzadeh, Mahdi ; Guity, Kamran ; Fallah, Mohammad-Sadegh ; Pourhassan, Hoda ; Azizi, Fereidoun ; Daneshpour, Maryam S.</creator><creatorcontrib>Sedaghati-khayat, Bahareh ; Barzin, Maryam ; Akbarzadeh, Mahdi ; Guity, Kamran ; Fallah, Mohammad-Sadegh ; Pourhassan, Hoda ; Azizi, Fereidoun ; Daneshpour, Maryam S.</creatorcontrib><description>Background
Obesity is currently an international epidemic and metabolic derangements pose these individuals at greater risk for future morbidity and mortality. Genetics and environmental factors have undeniable effects and among genetic risk factors, FTO/CETP genes are important. The current study examines the interaction between obesity phenotypes and FTO/CETP SNPs and their effects on lipid profile changes.
Materials and methods
We selected 954 adult subjects from TCGS (47.9% male). Participants were stratified according to their BMI and presence of metabolic syndrome according to the Joint Interim Statement (JIS) definition. Nine selected polymorphisms from FTO/CETP genes were genotyped using Tetra ARMS-PCR method. After age and sex adjustment the interaction of 9 markers with lipid profiles among phenotypes were tested by PASW.
Results
In three main groups, HDL_C level had a strong significant association with CETP markers: (rs3764261,
β
(95% CI) − 0.48(− 0.61 to − 0.35),
P
= 1.0 × 10
−11
), (rs1800775,
β
(95% CI) 0.5(0.36;0.65),
P
= 1.0 × 10
−6
) and (rs1864163,
β
(95% CI) 0.3(0.16;0.43),
P
= 9.1 × 10
−5
). This association was also seen in rs7202116 within the total population. In only unhealthy metabolic obese (MUHO) subgroups four new FTO markers (rs1421085, rs1121980, rs1558902 and rs8050136) (
P
value < 0.01) demonstrated significant association, even after lipid profile adjustment.
Conclusion
In the present study, we investigated the association between obesity phenotypes and some variations in FTO/CETP genes for the first time. Our study showed that four markers in the first intron of the FTO gene should be the risk marker in MUHO participants.
Level of Evidence
Level III, case-control study</description><identifier>ISSN: 1590-1262</identifier><identifier>ISSN: 1124-4909</identifier><identifier>EISSN: 1590-1262</identifier><identifier>DOI: 10.1007/s40519-018-0493-2</identifier><identifier>PMID: 29525920</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Anorexia ; Blood pressure ; Bulimia ; Cholesterol ; Diabetes ; Genes ; Genetics ; Hypertension ; Lipids ; Medicine ; Medicine & Public Health ; Metabolic syndrome ; Obesity ; Original Article ; Population ; Proteins ; Psychiatry ; Research centers ; Studies</subject><ispartof>Eating and weight disorders, 2020-02, Vol.25 (1), p.25-35</ispartof><rights>Springer International Publishing AG, part of Springer Nature 2018</rights><rights>Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-b4181d93b165c4c933fefe24c447284e7833c013f22708f42edab13e0d48e0fb3</citedby><cites>FETCH-LOGICAL-c372t-b4181d93b165c4c933fefe24c447284e7833c013f22708f42edab13e0d48e0fb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s40519-018-0493-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s40519-018-0493-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29525920$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sedaghati-khayat, Bahareh</creatorcontrib><creatorcontrib>Barzin, Maryam</creatorcontrib><creatorcontrib>Akbarzadeh, Mahdi</creatorcontrib><creatorcontrib>Guity, Kamran</creatorcontrib><creatorcontrib>Fallah, Mohammad-Sadegh</creatorcontrib><creatorcontrib>Pourhassan, Hoda</creatorcontrib><creatorcontrib>Azizi, Fereidoun</creatorcontrib><creatorcontrib>Daneshpour, Maryam S.</creatorcontrib><title>Lack of association between FTO gene variations and metabolic healthy obese (MHO) phenotype: Tehran Cardio-metabolic Genetic Study (TCGS)</title><title>Eating and weight disorders</title><addtitle>Eat Weight Disord</addtitle><addtitle>Eat Weight Disord</addtitle><description>Background
Obesity is currently an international epidemic and metabolic derangements pose these individuals at greater risk for future morbidity and mortality. Genetics and environmental factors have undeniable effects and among genetic risk factors, FTO/CETP genes are important. The current study examines the interaction between obesity phenotypes and FTO/CETP SNPs and their effects on lipid profile changes.
Materials and methods
We selected 954 adult subjects from TCGS (47.9% male). Participants were stratified according to their BMI and presence of metabolic syndrome according to the Joint Interim Statement (JIS) definition. Nine selected polymorphisms from FTO/CETP genes were genotyped using Tetra ARMS-PCR method. After age and sex adjustment the interaction of 9 markers with lipid profiles among phenotypes were tested by PASW.
Results
In three main groups, HDL_C level had a strong significant association with CETP markers: (rs3764261,
β
(95% CI) − 0.48(− 0.61 to − 0.35),
P
= 1.0 × 10
−11
), (rs1800775,
β
(95% CI) 0.5(0.36;0.65),
P
= 1.0 × 10
−6
) and (rs1864163,
β
(95% CI) 0.3(0.16;0.43),
P
= 9.1 × 10
−5
). This association was also seen in rs7202116 within the total population. In only unhealthy metabolic obese (MUHO) subgroups four new FTO markers (rs1421085, rs1121980, rs1558902 and rs8050136) (
P
value < 0.01) demonstrated significant association, even after lipid profile adjustment.
Conclusion
In the present study, we investigated the association between obesity phenotypes and some variations in FTO/CETP genes for the first time. Our study showed that four markers in the first intron of the FTO gene should be the risk marker in MUHO participants.
Level of Evidence
Level III, case-control study</description><subject>Anorexia</subject><subject>Blood pressure</subject><subject>Bulimia</subject><subject>Cholesterol</subject><subject>Diabetes</subject><subject>Genes</subject><subject>Genetics</subject><subject>Hypertension</subject><subject>Lipids</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic syndrome</subject><subject>Obesity</subject><subject>Original Article</subject><subject>Population</subject><subject>Proteins</subject><subject>Psychiatry</subject><subject>Research centers</subject><subject>Studies</subject><issn>1590-1262</issn><issn>1124-4909</issn><issn>1590-1262</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp1kc1O3DAURi3UCijlAbqpLLEZFinXP5kk7NCoDJUGzYLp2nKcGyY0Yw-2A5pH6FvXo0CpkLq6lu75Pl_pEPKFwTcGUFwECTmrMmBlBrISGT8gxyyvIGN8yj_88z4in0J4AJBMCDgkR7zKeV5xOCa_F9r8oq6lOgRnOh07Z2mN8RnR0uvVkt6jRfqk_bgKVNuGbjDq2vWdoWvUfVzvqKsxIJ3c3izP6XaN1sXdFi_pCtdeWzrTvulc9habp9KY5l0cmh2drGbzu_PP5GOr-4CnL_OE_Lz-vprdZIvl_MfsapEZUfCY1ZKVrKlEzaa5kaYSosUWuTRSFryUWJRCGGCi5byAspUcG10zgdDIEqGtxQmZjL1b7x4HDFFtumCw77VFNwTFU5hBXsA0oWfv0Ac3eJuuU1zkIAA48ESxkTLeheCxVVvfbbTfKQZq70mNnlTypPae1D7z9aV5qDfY_E28ikkAH4GQVvYe_dvX_2_9A_pdnDY</recordid><startdate>20200201</startdate><enddate>20200201</enddate><creator>Sedaghati-khayat, Bahareh</creator><creator>Barzin, Maryam</creator><creator>Akbarzadeh, Mahdi</creator><creator>Guity, Kamran</creator><creator>Fallah, Mohammad-Sadegh</creator><creator>Pourhassan, Hoda</creator><creator>Azizi, Fereidoun</creator><creator>Daneshpour, Maryam S.</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>7X8</scope></search><sort><creationdate>20200201</creationdate><title>Lack of association between FTO gene variations and metabolic healthy obese (MHO) phenotype: Tehran Cardio-metabolic Genetic Study (TCGS)</title><author>Sedaghati-khayat, Bahareh ; Barzin, Maryam ; Akbarzadeh, Mahdi ; Guity, Kamran ; Fallah, Mohammad-Sadegh ; Pourhassan, Hoda ; Azizi, Fereidoun ; Daneshpour, Maryam S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-b4181d93b165c4c933fefe24c447284e7833c013f22708f42edab13e0d48e0fb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Anorexia</topic><topic>Blood pressure</topic><topic>Bulimia</topic><topic>Cholesterol</topic><topic>Diabetes</topic><topic>Genes</topic><topic>Genetics</topic><topic>Hypertension</topic><topic>Lipids</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic syndrome</topic><topic>Obesity</topic><topic>Original Article</topic><topic>Population</topic><topic>Proteins</topic><topic>Psychiatry</topic><topic>Research centers</topic><topic>Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sedaghati-khayat, Bahareh</creatorcontrib><creatorcontrib>Barzin, Maryam</creatorcontrib><creatorcontrib>Akbarzadeh, Mahdi</creatorcontrib><creatorcontrib>Guity, Kamran</creatorcontrib><creatorcontrib>Fallah, Mohammad-Sadegh</creatorcontrib><creatorcontrib>Pourhassan, Hoda</creatorcontrib><creatorcontrib>Azizi, Fereidoun</creatorcontrib><creatorcontrib>Daneshpour, Maryam S.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>MEDLINE - Academic</collection><jtitle>Eating and weight disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sedaghati-khayat, Bahareh</au><au>Barzin, Maryam</au><au>Akbarzadeh, Mahdi</au><au>Guity, Kamran</au><au>Fallah, Mohammad-Sadegh</au><au>Pourhassan, Hoda</au><au>Azizi, Fereidoun</au><au>Daneshpour, Maryam S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lack of association between FTO gene variations and metabolic healthy obese (MHO) phenotype: Tehran Cardio-metabolic Genetic Study (TCGS)</atitle><jtitle>Eating and weight disorders</jtitle><stitle>Eat Weight Disord</stitle><addtitle>Eat Weight Disord</addtitle><date>2020-02-01</date><risdate>2020</risdate><volume>25</volume><issue>1</issue><spage>25</spage><epage>35</epage><pages>25-35</pages><issn>1590-1262</issn><issn>1124-4909</issn><eissn>1590-1262</eissn><abstract>Background
Obesity is currently an international epidemic and metabolic derangements pose these individuals at greater risk for future morbidity and mortality. Genetics and environmental factors have undeniable effects and among genetic risk factors, FTO/CETP genes are important. The current study examines the interaction between obesity phenotypes and FTO/CETP SNPs and their effects on lipid profile changes.
Materials and methods
We selected 954 adult subjects from TCGS (47.9% male). Participants were stratified according to their BMI and presence of metabolic syndrome according to the Joint Interim Statement (JIS) definition. Nine selected polymorphisms from FTO/CETP genes were genotyped using Tetra ARMS-PCR method. After age and sex adjustment the interaction of 9 markers with lipid profiles among phenotypes were tested by PASW.
Results
In three main groups, HDL_C level had a strong significant association with CETP markers: (rs3764261,
β
(95% CI) − 0.48(− 0.61 to − 0.35),
P
= 1.0 × 10
−11
), (rs1800775,
β
(95% CI) 0.5(0.36;0.65),
P
= 1.0 × 10
−6
) and (rs1864163,
β
(95% CI) 0.3(0.16;0.43),
P
= 9.1 × 10
−5
). This association was also seen in rs7202116 within the total population. In only unhealthy metabolic obese (MUHO) subgroups four new FTO markers (rs1421085, rs1121980, rs1558902 and rs8050136) (
P
value < 0.01) demonstrated significant association, even after lipid profile adjustment.
Conclusion
In the present study, we investigated the association between obesity phenotypes and some variations in FTO/CETP genes for the first time. Our study showed that four markers in the first intron of the FTO gene should be the risk marker in MUHO participants.
Level of Evidence
Level III, case-control study</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>29525920</pmid><doi>10.1007/s40519-018-0493-2</doi><tpages>11</tpages></addata></record> |
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| ispartof | Eating and weight disorders, 2020-02, Vol.25 (1), p.25-35 |
| issn | 1590-1262 1124-4909 1590-1262 |
| language | eng |
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| source | SpringerLink Journals |
| subjects | Anorexia Blood pressure Bulimia Cholesterol Diabetes Genes Genetics Hypertension Lipids Medicine Medicine & Public Health Metabolic syndrome Obesity Original Article Population Proteins Psychiatry Research centers Studies |
| title | Lack of association between FTO gene variations and metabolic healthy obese (MHO) phenotype: Tehran Cardio-metabolic Genetic Study (TCGS) |
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