Gut microbiota dysbiosis is associated with Henoch-Schönlein Purpura in children
Alterations in the intestinal microbiota have been associated with the development of allergic diseases, such as asthma and food allergies. However, there is no report detailing the role of microbiota alterations in Henoch-Schönlein Purpura (HSP) development. A total of 85 children with HSP and 70 h...
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| Veröffentlicht in: | International immunopharmacology 2018-05, Vol.58, p.1-8 |
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| creator | Wang, Xingcui Zhang, Lei Wang, Ying Liu, Xuemei Zhang, Hongxia Liu, Yi Shen, Nan Yang, Junjie Gai, Zhongtao |
| description | Alterations in the intestinal microbiota have been associated with the development of allergic diseases, such as asthma and food allergies. However, there is no report detailing the role of microbiota alterations in Henoch-Schönlein Purpura (HSP) development.
A total of 85 children with HSP and 70 healthy children were recruited for this study. Intestinal microbiota composition was analyzed by 16S rRNA gene-based pyrosequencing. Fecal microbial diversity and composition were compared.
We compared the gut microbiota of 155 subjects and found that children with HSP exhibited gut microbial dysbiosis. Lower microbial diversity and richness were found in HSP patients when compared to the control group. Based on an analysis of similarities, the composition of the microbiota in HSP patients was also different from that of the control group (r = 0.306, P = 0.001). The relative abundance of the bacterial genera Dialister (P |
| doi_str_mv | 10.1016/j.intimp.2018.03.003 |
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A total of 85 children with HSP and 70 healthy children were recruited for this study. Intestinal microbiota composition was analyzed by 16S rRNA gene-based pyrosequencing. Fecal microbial diversity and composition were compared.
We compared the gut microbiota of 155 subjects and found that children with HSP exhibited gut microbial dysbiosis. Lower microbial diversity and richness were found in HSP patients when compared to the control group. Based on an analysis of similarities, the composition of the microbiota in HSP patients was also different from that of the control group (r = 0.306, P = 0.001). The relative abundance of the bacterial genera Dialister (P < 0.0001), Roseburia (P < 0.0001), and Parasutterella (P < 0.0001) was significantly decreased in HSP children, while the relative abundance of Parabacteroides (P < 0.006) and Enterococcus (P < 0.0001) in these children was significantly increased. Based on Spearman correlation analysis, the LOS showed a significant negative (P < 0.05) correlation with the genera Paraprevotella and Roseburia. Meanwhile, IgA levels exhibited a significant negative (P < 0.01) correlation with the genus Bifidobacterium.
Our results indicate that HSP is associated with significant compositional and structural changes in the gut microbiota. These results enhance the potential for future microbial-based therapies to improve the clinical outcome of HSP in children.
•The lower diversity and richness of microbiota were found in HSP patients•The composition of microbiota in HSP patients was different from healthy control.•The gut microbiota was associated with the clinical indices•This is the first study about the gut microbiota dysbiosis associated with HSP.]]></description><identifier>ISSN: 1567-5769</identifier><identifier>EISSN: 1878-1705</identifier><identifier>DOI: 10.1016/j.intimp.2018.03.003</identifier><identifier>PMID: 29525681</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Abundance ; Allergic diseases ; Allergies ; Asthma ; Children ; Childrens health ; Composition ; Correlation analysis ; Digestive system ; Dysbacteriosis ; Dysbiosis ; Fecal microflora ; Food allergies ; Gastrointestinal tract ; Henoch-Schönlein Purpura ; IgA ; Immunoglobulin A ; Intestinal microflora ; Microbiota ; Microorganisms ; Patients ; Relative abundance ; rRNA 16S ; Schonlein-Henoch purpura</subject><ispartof>International immunopharmacology, 2018-05, Vol.58, p.1-8</ispartof><rights>2018</rights><rights>Copyright © 2018. Published by Elsevier B.V.</rights><rights>Copyright Elsevier BV May 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-6070b9c5d792aa2f7ac72ce117cdfbf8b482e8f9db1a391579579ec0dca4ae7e3</citedby><cites>FETCH-LOGICAL-c390t-6070b9c5d792aa2f7ac72ce117cdfbf8b482e8f9db1a391579579ec0dca4ae7e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.intimp.2018.03.003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27926,27927,45997</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29525681$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Xingcui</creatorcontrib><creatorcontrib>Zhang, Lei</creatorcontrib><creatorcontrib>Wang, Ying</creatorcontrib><creatorcontrib>Liu, Xuemei</creatorcontrib><creatorcontrib>Zhang, Hongxia</creatorcontrib><creatorcontrib>Liu, Yi</creatorcontrib><creatorcontrib>Shen, Nan</creatorcontrib><creatorcontrib>Yang, Junjie</creatorcontrib><creatorcontrib>Gai, Zhongtao</creatorcontrib><title>Gut microbiota dysbiosis is associated with Henoch-Schönlein Purpura in children</title><title>International immunopharmacology</title><addtitle>Int Immunopharmacol</addtitle><description><![CDATA[Alterations in the intestinal microbiota have been associated with the development of allergic diseases, such as asthma and food allergies. However, there is no report detailing the role of microbiota alterations in Henoch-Schönlein Purpura (HSP) development.
A total of 85 children with HSP and 70 healthy children were recruited for this study. Intestinal microbiota composition was analyzed by 16S rRNA gene-based pyrosequencing. Fecal microbial diversity and composition were compared.
We compared the gut microbiota of 155 subjects and found that children with HSP exhibited gut microbial dysbiosis. Lower microbial diversity and richness were found in HSP patients when compared to the control group. Based on an analysis of similarities, the composition of the microbiota in HSP patients was also different from that of the control group (r = 0.306, P = 0.001). The relative abundance of the bacterial genera Dialister (P < 0.0001), Roseburia (P < 0.0001), and Parasutterella (P < 0.0001) was significantly decreased in HSP children, while the relative abundance of Parabacteroides (P < 0.006) and Enterococcus (P < 0.0001) in these children was significantly increased. Based on Spearman correlation analysis, the LOS showed a significant negative (P < 0.05) correlation with the genera Paraprevotella and Roseburia. Meanwhile, IgA levels exhibited a significant negative (P < 0.01) correlation with the genus Bifidobacterium.
Our results indicate that HSP is associated with significant compositional and structural changes in the gut microbiota. These results enhance the potential for future microbial-based therapies to improve the clinical outcome of HSP in children.
•The lower diversity and richness of microbiota were found in HSP patients•The composition of microbiota in HSP patients was different from healthy control.•The gut microbiota was associated with the clinical indices•This is the first study about the gut microbiota dysbiosis associated with HSP.]]></description><subject>Abundance</subject><subject>Allergic diseases</subject><subject>Allergies</subject><subject>Asthma</subject><subject>Children</subject><subject>Childrens health</subject><subject>Composition</subject><subject>Correlation analysis</subject><subject>Digestive system</subject><subject>Dysbacteriosis</subject><subject>Dysbiosis</subject><subject>Fecal microflora</subject><subject>Food allergies</subject><subject>Gastrointestinal tract</subject><subject>Henoch-Schönlein Purpura</subject><subject>IgA</subject><subject>Immunoglobulin A</subject><subject>Intestinal microflora</subject><subject>Microbiota</subject><subject>Microorganisms</subject><subject>Patients</subject><subject>Relative abundance</subject><subject>rRNA 16S</subject><subject>Schonlein-Henoch purpura</subject><issn>1567-5769</issn><issn>1878-1705</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kMtKxDAUhoMo3t9ApODGTetJO2mSjSCDNxBU1HVIk1MmQy9j0irzYr6AL2aGURcuhAP5Cd_5Ez5CjihkFGh5Ns9cN7h2keVARQZFBlBskF0quEgpB7YZMyt5yngpd8heCHOAeD-h22QnlyxnpaC75PF6HJLWGd9Xrh90YpchhuBCEkeH0BunB7TJuxtmyQ12vZmlT2b2-dE16LrkYfSL0eskRjNzjfXYHZCtWjcBD7_PffJydfk8vUnv7q9vpxd3qSkkDGkJHCppmOUy1zqvuTY8N0gpN7aualFNRI6ilraiupCUcRkHDVijJxo5FvvkdN278P3riGFQrQsGm0Z32I9BRS0FBQYCInryB533o-_i7yLFSyoFK2WkJmsqygjBY60W3rXaLxUFtVKu5mqtfNUtFBQqKo9rx9_lY9Wi_V36cRyB8zWA0cabQ6-CcdgZtM6jGZTt3f8vfAFJe5Vq</recordid><startdate>201805</startdate><enddate>201805</enddate><creator>Wang, Xingcui</creator><creator>Zhang, Lei</creator><creator>Wang, Ying</creator><creator>Liu, Xuemei</creator><creator>Zhang, Hongxia</creator><creator>Liu, Yi</creator><creator>Shen, Nan</creator><creator>Yang, Junjie</creator><creator>Gai, Zhongtao</creator><general>Elsevier B.V</general><general>Elsevier BV</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T5</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201805</creationdate><title>Gut microbiota dysbiosis is associated with Henoch-Schönlein Purpura in children</title><author>Wang, Xingcui ; Zhang, Lei ; Wang, Ying ; Liu, Xuemei ; Zhang, Hongxia ; Liu, Yi ; Shen, Nan ; Yang, Junjie ; Gai, Zhongtao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-6070b9c5d792aa2f7ac72ce117cdfbf8b482e8f9db1a391579579ec0dca4ae7e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Abundance</topic><topic>Allergic diseases</topic><topic>Allergies</topic><topic>Asthma</topic><topic>Children</topic><topic>Childrens health</topic><topic>Composition</topic><topic>Correlation analysis</topic><topic>Digestive system</topic><topic>Dysbacteriosis</topic><topic>Dysbiosis</topic><topic>Fecal microflora</topic><topic>Food allergies</topic><topic>Gastrointestinal tract</topic><topic>Henoch-Schönlein Purpura</topic><topic>IgA</topic><topic>Immunoglobulin A</topic><topic>Intestinal microflora</topic><topic>Microbiota</topic><topic>Microorganisms</topic><topic>Patients</topic><topic>Relative abundance</topic><topic>rRNA 16S</topic><topic>Schonlein-Henoch purpura</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Xingcui</creatorcontrib><creatorcontrib>Zhang, Lei</creatorcontrib><creatorcontrib>Wang, Ying</creatorcontrib><creatorcontrib>Liu, Xuemei</creatorcontrib><creatorcontrib>Zhang, Hongxia</creatorcontrib><creatorcontrib>Liu, Yi</creatorcontrib><creatorcontrib>Shen, Nan</creatorcontrib><creatorcontrib>Yang, Junjie</creatorcontrib><creatorcontrib>Gai, Zhongtao</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International immunopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Xingcui</au><au>Zhang, Lei</au><au>Wang, Ying</au><au>Liu, Xuemei</au><au>Zhang, Hongxia</au><au>Liu, Yi</au><au>Shen, Nan</au><au>Yang, Junjie</au><au>Gai, Zhongtao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gut microbiota dysbiosis is associated with Henoch-Schönlein Purpura in children</atitle><jtitle>International immunopharmacology</jtitle><addtitle>Int Immunopharmacol</addtitle><date>2018-05</date><risdate>2018</risdate><volume>58</volume><spage>1</spage><epage>8</epage><pages>1-8</pages><issn>1567-5769</issn><eissn>1878-1705</eissn><abstract><![CDATA[Alterations in the intestinal microbiota have been associated with the development of allergic diseases, such as asthma and food allergies. However, there is no report detailing the role of microbiota alterations in Henoch-Schönlein Purpura (HSP) development.
A total of 85 children with HSP and 70 healthy children were recruited for this study. Intestinal microbiota composition was analyzed by 16S rRNA gene-based pyrosequencing. Fecal microbial diversity and composition were compared.
We compared the gut microbiota of 155 subjects and found that children with HSP exhibited gut microbial dysbiosis. Lower microbial diversity and richness were found in HSP patients when compared to the control group. Based on an analysis of similarities, the composition of the microbiota in HSP patients was also different from that of the control group (r = 0.306, P = 0.001). The relative abundance of the bacterial genera Dialister (P < 0.0001), Roseburia (P < 0.0001), and Parasutterella (P < 0.0001) was significantly decreased in HSP children, while the relative abundance of Parabacteroides (P < 0.006) and Enterococcus (P < 0.0001) in these children was significantly increased. Based on Spearman correlation analysis, the LOS showed a significant negative (P < 0.05) correlation with the genera Paraprevotella and Roseburia. Meanwhile, IgA levels exhibited a significant negative (P < 0.01) correlation with the genus Bifidobacterium.
Our results indicate that HSP is associated with significant compositional and structural changes in the gut microbiota. These results enhance the potential for future microbial-based therapies to improve the clinical outcome of HSP in children.
•The lower diversity and richness of microbiota were found in HSP patients•The composition of microbiota in HSP patients was different from healthy control.•The gut microbiota was associated with the clinical indices•This is the first study about the gut microbiota dysbiosis associated with HSP.]]></abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>29525681</pmid><doi>10.1016/j.intimp.2018.03.003</doi><tpages>8</tpages></addata></record> |
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| subjects | Abundance Allergic diseases Allergies Asthma Children Childrens health Composition Correlation analysis Digestive system Dysbacteriosis Dysbiosis Fecal microflora Food allergies Gastrointestinal tract Henoch-Schönlein Purpura IgA Immunoglobulin A Intestinal microflora Microbiota Microorganisms Patients Relative abundance rRNA 16S Schonlein-Henoch purpura |
| title | Gut microbiota dysbiosis is associated with Henoch-Schönlein Purpura in children |
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