Overexpression of SLC7A11: a novel oncogene and an indicator of unfavorable prognosis for liver carcinoma
SLC7A11 is a gene that encodes a cystine-glutamate antiporter, which has been detected to be overexpressed in various cancers. Thus, we aimed to validate its expression and clinical significance in liver cancer. Bioinformatic analysis was conducted and a tissue microarray was utilized for detecting...
Gespeichert in:
| Veröffentlicht in: | Future oncology (London, England) England), 2018-04, Vol.14 (10), p.927-936 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 936 |
|---|---|
| container_issue | 10 |
| container_start_page | 927 |
| container_title | Future oncology (London, England) |
| container_volume | 14 |
| creator | Zhang, Liang Huang, Yi Ling, Junjun Zhuo, Wenlei Yu, Zhen Luo, Yunbo Zhu, Yi |
| description | SLC7A11 is a gene that encodes a cystine-glutamate antiporter, which has been detected to be overexpressed in various cancers. Thus, we aimed to validate its expression and clinical significance in liver cancer.
Bioinformatic analysis was conducted and a tissue microarray was utilized for detecting SLC7A11 expression in liver cancer tissues by immunohistochemistry assay.
High expressions of SLC7A11 have no association with clinical parameters such as age, sex and clinical stages, except for advanced pathological stages. Cox regression analysis revealed that SLC7A11 might be an independent prognostic factor for liver cancer patients.
SLC7A11 overexpression might be a novel biomarker and a potential unfavorable prognostic factor as well as a potential therapeutic target for liver carcinoma. |
| doi_str_mv | 10.2217/fon-2017-0540 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2013104463</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2275865944</sourcerecordid><originalsourceid>FETCH-LOGICAL-c437t-6cb818faddd3ca850b9dd3d6be4c08a2e5131d71c91c7c4c65128e1f3f81dd93</originalsourceid><addsrcrecordid>eNp1kc2LFDEQxYMo7ocevUrAi5fWVD46aW_LoK4wsAf3HtJJZcnSk4zJ9KD_vRlm9SB4CFVF_fIo3iPkDbAPnIP-GEseOAM9MCXZM3IJWsrBCAbPey_1NIzjJC_IVWuPjEktFHtJLvikuOGKXZJ0d8SKP_cVW0sl0xLp9-1G3wB8oo7mcsSFluzLA2akLof-aMoheXco9USvObpjqW5ekO5recilpUZjXy6pS1Pvqk-57Nwr8iK6peHrp3pN7r98vt_cDtu7r982N9vBS6EPw-hnAya6EILwzig2T70L44zSM-M4KhAQNPgJvPbSjwq4QYgiGghhEtfk_Vm2H_NjxXawu9Q8LovLWNZmu1cCmJSj6Oi7f9DHstbcj7Oca2VGNUnZqeFM-Vpaqxjtvqadq78sMHuKwPYITrLaniLo_Nsn1XXeYfhL__G8A9MZiOth7b77hNmjPU_9R-p-4X_EfwOIZ5WU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2275865944</pqid></control><display><type>article</type><title>Overexpression of SLC7A11: a novel oncogene and an indicator of unfavorable prognosis for liver carcinoma</title><source>PubMed Central</source><creator>Zhang, Liang ; Huang, Yi ; Ling, Junjun ; Zhuo, Wenlei ; Yu, Zhen ; Luo, Yunbo ; Zhu, Yi</creator><creatorcontrib>Zhang, Liang ; Huang, Yi ; Ling, Junjun ; Zhuo, Wenlei ; Yu, Zhen ; Luo, Yunbo ; Zhu, Yi</creatorcontrib><description>SLC7A11 is a gene that encodes a cystine-glutamate antiporter, which has been detected to be overexpressed in various cancers. Thus, we aimed to validate its expression and clinical significance in liver cancer.
Bioinformatic analysis was conducted and a tissue microarray was utilized for detecting SLC7A11 expression in liver cancer tissues by immunohistochemistry assay.
High expressions of SLC7A11 have no association with clinical parameters such as age, sex and clinical stages, except for advanced pathological stages. Cox regression analysis revealed that SLC7A11 might be an independent prognostic factor for liver cancer patients.
SLC7A11 overexpression might be a novel biomarker and a potential unfavorable prognostic factor as well as a potential therapeutic target for liver carcinoma.</description><identifier>ISSN: 1479-6694</identifier><identifier>EISSN: 1744-8301</identifier><identifier>DOI: 10.2217/fon-2017-0540</identifier><identifier>PMID: 29528250</identifier><language>eng</language><publisher>England: Future Medicine Ltd</publisher><subject>Amino acids ; Annotations ; Apoptosis ; Bioinformatics ; Genes ; Glucose ; Hazardous materials ; immunohistochemistry ; Liver cancer ; liver carcinoma ; Medical prognosis ; Metabolism ; Ontology ; Oxidative stress ; prognosis ; Proteins ; SLC7A11 ; Survival analysis ; tissue microarray</subject><ispartof>Future oncology (London, England), 2018-04, Vol.14 (10), p.927-936</ispartof><rights>2018 Future Medicine Ltd</rights><rights>Copyright Future Medicine Ltd Apr 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c437t-6cb818faddd3ca850b9dd3d6be4c08a2e5131d71c91c7c4c65128e1f3f81dd93</citedby><cites>FETCH-LOGICAL-c437t-6cb818faddd3ca850b9dd3d6be4c08a2e5131d71c91c7c4c65128e1f3f81dd93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29528250$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Liang</creatorcontrib><creatorcontrib>Huang, Yi</creatorcontrib><creatorcontrib>Ling, Junjun</creatorcontrib><creatorcontrib>Zhuo, Wenlei</creatorcontrib><creatorcontrib>Yu, Zhen</creatorcontrib><creatorcontrib>Luo, Yunbo</creatorcontrib><creatorcontrib>Zhu, Yi</creatorcontrib><title>Overexpression of SLC7A11: a novel oncogene and an indicator of unfavorable prognosis for liver carcinoma</title><title>Future oncology (London, England)</title><addtitle>Future Oncol</addtitle><description>SLC7A11 is a gene that encodes a cystine-glutamate antiporter, which has been detected to be overexpressed in various cancers. Thus, we aimed to validate its expression and clinical significance in liver cancer.
Bioinformatic analysis was conducted and a tissue microarray was utilized for detecting SLC7A11 expression in liver cancer tissues by immunohistochemistry assay.
High expressions of SLC7A11 have no association with clinical parameters such as age, sex and clinical stages, except for advanced pathological stages. Cox regression analysis revealed that SLC7A11 might be an independent prognostic factor for liver cancer patients.
SLC7A11 overexpression might be a novel biomarker and a potential unfavorable prognostic factor as well as a potential therapeutic target for liver carcinoma.</description><subject>Amino acids</subject><subject>Annotations</subject><subject>Apoptosis</subject><subject>Bioinformatics</subject><subject>Genes</subject><subject>Glucose</subject><subject>Hazardous materials</subject><subject>immunohistochemistry</subject><subject>Liver cancer</subject><subject>liver carcinoma</subject><subject>Medical prognosis</subject><subject>Metabolism</subject><subject>Ontology</subject><subject>Oxidative stress</subject><subject>prognosis</subject><subject>Proteins</subject><subject>SLC7A11</subject><subject>Survival analysis</subject><subject>tissue microarray</subject><issn>1479-6694</issn><issn>1744-8301</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp1kc2LFDEQxYMo7ocevUrAi5fWVD46aW_LoK4wsAf3HtJJZcnSk4zJ9KD_vRlm9SB4CFVF_fIo3iPkDbAPnIP-GEseOAM9MCXZM3IJWsrBCAbPey_1NIzjJC_IVWuPjEktFHtJLvikuOGKXZJ0d8SKP_cVW0sl0xLp9-1G3wB8oo7mcsSFluzLA2akLof-aMoheXco9USvObpjqW5ekO5recilpUZjXy6pS1Pvqk-57Nwr8iK6peHrp3pN7r98vt_cDtu7r982N9vBS6EPw-hnAya6EILwzig2T70L44zSM-M4KhAQNPgJvPbSjwq4QYgiGghhEtfk_Vm2H_NjxXawu9Q8LovLWNZmu1cCmJSj6Oi7f9DHstbcj7Oca2VGNUnZqeFM-Vpaqxjtvqadq78sMHuKwPYITrLaniLo_Nsn1XXeYfhL__G8A9MZiOth7b77hNmjPU_9R-p-4X_EfwOIZ5WU</recordid><startdate>20180401</startdate><enddate>20180401</enddate><creator>Zhang, Liang</creator><creator>Huang, Yi</creator><creator>Ling, Junjun</creator><creator>Zhuo, Wenlei</creator><creator>Yu, Zhen</creator><creator>Luo, Yunbo</creator><creator>Zhu, Yi</creator><general>Future Medicine Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>EHMNL</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20180401</creationdate><title>Overexpression of SLC7A11: a novel oncogene and an indicator of unfavorable prognosis for liver carcinoma</title><author>Zhang, Liang ; Huang, Yi ; Ling, Junjun ; Zhuo, Wenlei ; Yu, Zhen ; Luo, Yunbo ; Zhu, Yi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-6cb818faddd3ca850b9dd3d6be4c08a2e5131d71c91c7c4c65128e1f3f81dd93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Amino acids</topic><topic>Annotations</topic><topic>Apoptosis</topic><topic>Bioinformatics</topic><topic>Genes</topic><topic>Glucose</topic><topic>Hazardous materials</topic><topic>immunohistochemistry</topic><topic>Liver cancer</topic><topic>liver carcinoma</topic><topic>Medical prognosis</topic><topic>Metabolism</topic><topic>Ontology</topic><topic>Oxidative stress</topic><topic>prognosis</topic><topic>Proteins</topic><topic>SLC7A11</topic><topic>Survival analysis</topic><topic>tissue microarray</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Liang</creatorcontrib><creatorcontrib>Huang, Yi</creatorcontrib><creatorcontrib>Ling, Junjun</creatorcontrib><creatorcontrib>Zhuo, Wenlei</creatorcontrib><creatorcontrib>Yu, Zhen</creatorcontrib><creatorcontrib>Luo, Yunbo</creatorcontrib><creatorcontrib>Zhu, Yi</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>UK & Ireland Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Future oncology (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Liang</au><au>Huang, Yi</au><au>Ling, Junjun</au><au>Zhuo, Wenlei</au><au>Yu, Zhen</au><au>Luo, Yunbo</au><au>Zhu, Yi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Overexpression of SLC7A11: a novel oncogene and an indicator of unfavorable prognosis for liver carcinoma</atitle><jtitle>Future oncology (London, England)</jtitle><addtitle>Future Oncol</addtitle><date>2018-04-01</date><risdate>2018</risdate><volume>14</volume><issue>10</issue><spage>927</spage><epage>936</epage><pages>927-936</pages><issn>1479-6694</issn><eissn>1744-8301</eissn><abstract>SLC7A11 is a gene that encodes a cystine-glutamate antiporter, which has been detected to be overexpressed in various cancers. Thus, we aimed to validate its expression and clinical significance in liver cancer.
Bioinformatic analysis was conducted and a tissue microarray was utilized for detecting SLC7A11 expression in liver cancer tissues by immunohistochemistry assay.
High expressions of SLC7A11 have no association with clinical parameters such as age, sex and clinical stages, except for advanced pathological stages. Cox regression analysis revealed that SLC7A11 might be an independent prognostic factor for liver cancer patients.
SLC7A11 overexpression might be a novel biomarker and a potential unfavorable prognostic factor as well as a potential therapeutic target for liver carcinoma.</abstract><cop>England</cop><pub>Future Medicine Ltd</pub><pmid>29528250</pmid><doi>10.2217/fon-2017-0540</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1479-6694 |
| ispartof | Future oncology (London, England), 2018-04, Vol.14 (10), p.927-936 |
| issn | 1479-6694 1744-8301 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2013104463 |
| source | PubMed Central |
| subjects | Amino acids Annotations Apoptosis Bioinformatics Genes Glucose Hazardous materials immunohistochemistry Liver cancer liver carcinoma Medical prognosis Metabolism Ontology Oxidative stress prognosis Proteins SLC7A11 Survival analysis tissue microarray |
| title | Overexpression of SLC7A11: a novel oncogene and an indicator of unfavorable prognosis for liver carcinoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T17%3A17%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Overexpression%20of%20SLC7A11:%20a%20novel%20oncogene%20and%20an%20indicator%20of%20unfavorable%20prognosis%20for%20liver%20carcinoma&rft.jtitle=Future%20oncology%20(London,%20England)&rft.au=Zhang,%20Liang&rft.date=2018-04-01&rft.volume=14&rft.issue=10&rft.spage=927&rft.epage=936&rft.pages=927-936&rft.issn=1479-6694&rft.eissn=1744-8301&rft_id=info:doi/10.2217/fon-2017-0540&rft_dat=%3Cproquest_cross%3E2275865944%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2275865944&rft_id=info:pmid/29528250&rfr_iscdi=true |