Exposure of human melanocytes to UVB twice and subsequent incubation leads to cellular senescence and senescence-associated pigmentation through the prolonged p53 expression

•An in vitro model for melanocyte senescence using UVB exposure is proposed.•The protocol relies on UVB exposure twice and subsequent 2-week cultivation.•Melanocyte senescence accompanies hyperpigmentation via prolonged p53 expression. Ultraviolet radiation (UVR) is a well-known factor in skin aging...

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Veröffentlicht in:	Journal of dermatological science 2018-06, Vol.90 (3), p.303-312
Hauptverfasser:	Choi, Suh-Yeon, Bin, Bum-Ho, Kim, Wanil, Lee, Eunkyung, Lee, Tae Ryong, Cho, Eun-Gyung
Format:	Artikel
Sprache:	eng
Schlagworte:	Human melanocytes Hyperpigmentation p53 Senescence-associated pigmentation UVB-induced senescence
Online-Zugang:	Volltext
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