Diesel exhaust particles (DEP) induce an early redox imbalance followed by an IL-6 mediated inflammatory response on human conjunctival epithelial cells

The aim of this study was to evaluate the time course of oxidative stress markers and inflammatory mediators in human conjunctival epithelial cells (IOBA-NHC) exposed to diesel exhaust particles (DEP) for 1, 3, and 24 h. Reactive oxygen species (ROS) production, lipid and protein oxidation, Nrf2 pat...

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Veröffentlicht in:	Experimental eye research 2018-06, Vol.171, p.37-47
Hauptverfasser:	Lasagni Vitar, Romina M., Tau, Julia, Janezic, Natasha S., Tesone, Agustina I., Hvozda Arana, Ailen G., Reides, Claudia G., Berra, Alejandro, Ferreira, Sandra M., Llesuy, Susana F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Air Pollutants - toxicity Antioxidants Cell Line Cell Proliferation - drug effects Conjunctiva Conjunctiva - drug effects Conjunctiva - metabolism Diesel exhaust particles Epithelial Cells - drug effects Epithelial Cells - metabolism Fluorescent Antibody Technique, Indirect Glutathione - metabolism Glutathione Reductase - metabolism Glutathione Transferase - metabolism Humans Inflammation Interleukin-6 - metabolism Lipid Peroxidation Membrane Potentials - physiology Mitochondria - metabolism NADPH Oxidase 4 - metabolism NF-E2-Related Factor 2 - metabolism Oxidation-Reduction - drug effects Oxidative stress Oxidative Stress - physiology Peroxidase - metabolism Reactive Oxygen Species - metabolism Superoxides - metabolism Vehicle Emissions - toxicity
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