Correlation between the 24-h urinary angiotensinogen or aldosterone level and muscle mass: Japan shimanami health promoting program study
Our previous report indicated that sarcopenia is associated with arterial stiffness and cardiovascular death. The renin-angiotensin system (RAS) plays an important role in cardiovascular disease and its activation may be correlated with sarcopenia according to basic research. However, few clinical s...
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| Veröffentlicht in: | Hypertension research 2018-05, Vol.41 (5), p.326-333 |
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| creator | Mogi, Masaki Kohara, Katsuhiko Tabara, Yasuharu Tsukuda, Kana Igase, Michiya Horiuchi, Masatsugu |
| description | Our previous report indicated that sarcopenia is associated with arterial stiffness and cardiovascular death. The renin-angiotensin system (RAS) plays an important role in cardiovascular disease and its activation may be correlated with sarcopenia according to basic research. However, few clinical studies have assessed the correlation between skeletal muscle loss and RAS component concentrations in healthy subjects. The purpose of this study was to investigate the relationships between the excretion of angiotensinogen (AGT) and aldosterone (Ald) in 24-h urine samples and clinical and sarcopenic indices. A total of 344 people participated in a voluntary medical check-up program, "Anti-Aging Doc", and underwent measurement of their sarcopenia-related indices. Urine samples were collected for 24-h within 8 weeks after a medical check-up using a partition cup and a proportional sampling method. Urine AGT and Ald levels were evaluated by enzyme-linked immunosorbent assay (ELISA). After compensating for possible confounding parameters, including baPWV, the 24-h urinary excretion of AGT was independently and negatively associated with the thigh muscle cross-sectional area. On the other hand, urinary Ald excretion was not associated with sarcopenia-related indices after compensation, even though it showed a modest but significantly positive association with sarcopenic indices in single regression analysis. Urinary AGT was related to sarcopenic indices and may be involved in the pathogenesis of sarcopenia. On the other hand, urinary Ald was not related to sarcopenic indices when considering other risk factors. |
| doi_str_mv | 10.1038/s41440-018-0021-9 |
| format | Article |
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The renin-angiotensin system (RAS) plays an important role in cardiovascular disease and its activation may be correlated with sarcopenia according to basic research. However, few clinical studies have assessed the correlation between skeletal muscle loss and RAS component concentrations in healthy subjects. The purpose of this study was to investigate the relationships between the excretion of angiotensinogen (AGT) and aldosterone (Ald) in 24-h urine samples and clinical and sarcopenic indices. A total of 344 people participated in a voluntary medical check-up program, "Anti-Aging Doc", and underwent measurement of their sarcopenia-related indices. Urine samples were collected for 24-h within 8 weeks after a medical check-up using a partition cup and a proportional sampling method. Urine AGT and Ald levels were evaluated by enzyme-linked immunosorbent assay (ELISA). After compensating for possible confounding parameters, including baPWV, the 24-h urinary excretion of AGT was independently and negatively associated with the thigh muscle cross-sectional area. On the other hand, urinary Ald excretion was not associated with sarcopenia-related indices after compensation, even though it showed a modest but significantly positive association with sarcopenic indices in single regression analysis. Urinary AGT was related to sarcopenic indices and may be involved in the pathogenesis of sarcopenia. On the other hand, urinary Ald was not related to sarcopenic indices when considering other risk factors.</description><identifier>ISSN: 0916-9636</identifier><identifier>EISSN: 1348-4214</identifier><identifier>DOI: 10.1038/s41440-018-0021-9</identifier><identifier>PMID: 29523869</identifier><language>eng</language><publisher>England: Nature Publishing Group</publisher><subject>Aged ; Aged, 80 and over ; Aldosterone - urine ; Anatomy, Cross-Sectional ; Angiotensinogen - urine ; Electric Impedance ; Female ; Hand Strength ; Health Promotion ; Healthy Aging ; Humans ; Japan ; Male ; Middle Aged ; Muscle, Skeletal - anatomy & histology ; Muscle, Skeletal - physiology ; Renin-Angiotensin System - physiology ; Risk Factors ; Sarcopenia ; Sarcopenia - pathology ; Sarcopenia - urine ; Urine</subject><ispartof>Hypertension research, 2018-05, Vol.41 (5), p.326-333</ispartof><rights>Copyright Nature Publishing Group May 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c349t-3a27c2458a3a1cc3ef9fdcd5035e04456073994e6af3791111784979ead3c6593</citedby><cites>FETCH-LOGICAL-c349t-3a27c2458a3a1cc3ef9fdcd5035e04456073994e6af3791111784979ead3c6593</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29523869$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mogi, Masaki</creatorcontrib><creatorcontrib>Kohara, Katsuhiko</creatorcontrib><creatorcontrib>Tabara, Yasuharu</creatorcontrib><creatorcontrib>Tsukuda, Kana</creatorcontrib><creatorcontrib>Igase, Michiya</creatorcontrib><creatorcontrib>Horiuchi, Masatsugu</creatorcontrib><title>Correlation between the 24-h urinary angiotensinogen or aldosterone level and muscle mass: Japan shimanami health promoting program study</title><title>Hypertension research</title><addtitle>Hypertens Res</addtitle><description>Our previous report indicated that sarcopenia is associated with arterial stiffness and cardiovascular death. The renin-angiotensin system (RAS) plays an important role in cardiovascular disease and its activation may be correlated with sarcopenia according to basic research. However, few clinical studies have assessed the correlation between skeletal muscle loss and RAS component concentrations in healthy subjects. The purpose of this study was to investigate the relationships between the excretion of angiotensinogen (AGT) and aldosterone (Ald) in 24-h urine samples and clinical and sarcopenic indices. A total of 344 people participated in a voluntary medical check-up program, "Anti-Aging Doc", and underwent measurement of their sarcopenia-related indices. Urine samples were collected for 24-h within 8 weeks after a medical check-up using a partition cup and a proportional sampling method. Urine AGT and Ald levels were evaluated by enzyme-linked immunosorbent assay (ELISA). After compensating for possible confounding parameters, including baPWV, the 24-h urinary excretion of AGT was independently and negatively associated with the thigh muscle cross-sectional area. On the other hand, urinary Ald excretion was not associated with sarcopenia-related indices after compensation, even though it showed a modest but significantly positive association with sarcopenic indices in single regression analysis. Urinary AGT was related to sarcopenic indices and may be involved in the pathogenesis of sarcopenia. On the other hand, urinary Ald was not related to sarcopenic indices when considering other risk factors.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aldosterone - urine</subject><subject>Anatomy, Cross-Sectional</subject><subject>Angiotensinogen - urine</subject><subject>Electric Impedance</subject><subject>Female</subject><subject>Hand Strength</subject><subject>Health Promotion</subject><subject>Healthy Aging</subject><subject>Humans</subject><subject>Japan</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Muscle, Skeletal - anatomy & histology</subject><subject>Muscle, Skeletal - physiology</subject><subject>Renin-Angiotensin System - physiology</subject><subject>Risk Factors</subject><subject>Sarcopenia</subject><subject>Sarcopenia - pathology</subject><subject>Sarcopenia - urine</subject><subject>Urine</subject><issn>0916-9636</issn><issn>1348-4214</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkcluFDEQQC1ERIYkH5BLZIkLFwdvvZgbGrEqUi5wtiru6umO3PZgu4PmE_hrPJrAAdfBPrxaXI-Qa8FvBVf9u6yF1pxx0TPOpWDmBdkIpXumpdAvyYYb0TLTqvacvM75sTJ9Y8Qrci5NI1Xfmg35vY0poYcyx0AfsPxCDLRMSKVmE13THCAdKITdHAuGPIe4q0BMFPwQc8EUA1KPT-grNNBlzc4jXSDn9_Qb7CHQPM0LBFhmOiH4MtF9ikssc9gdX7sEC81lHQ6X5GwEn_Hq-b4gPz59_L79wu7uP3_dfrhjTmlTmALZOambHhQI5xSOZhzc0HDVINe6aXmnjNHYwqg6I-rpem06gzAo1zZGXZC3p7q1-88Vc7HLnB16DwHjmq3kQta91ajom__Qx7imUKerlKorbKToKyVOlEsx54Sj3af65XSwgtujJ3vyZKsne_Rkj0PcPFdeHxYc_mX8FaP-AFqEjvQ</recordid><startdate>20180501</startdate><enddate>20180501</enddate><creator>Mogi, Masaki</creator><creator>Kohara, Katsuhiko</creator><creator>Tabara, Yasuharu</creator><creator>Tsukuda, Kana</creator><creator>Igase, Michiya</creator><creator>Horiuchi, Masatsugu</creator><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20180501</creationdate><title>Correlation between the 24-h urinary angiotensinogen or aldosterone level and muscle mass: Japan shimanami health promoting program study</title><author>Mogi, Masaki ; Kohara, Katsuhiko ; Tabara, Yasuharu ; Tsukuda, Kana ; Igase, Michiya ; Horiuchi, Masatsugu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c349t-3a27c2458a3a1cc3ef9fdcd5035e04456073994e6af3791111784979ead3c6593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aldosterone - urine</topic><topic>Anatomy, Cross-Sectional</topic><topic>Angiotensinogen - urine</topic><topic>Electric Impedance</topic><topic>Female</topic><topic>Hand Strength</topic><topic>Health Promotion</topic><topic>Healthy Aging</topic><topic>Humans</topic><topic>Japan</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Muscle, Skeletal - anatomy & histology</topic><topic>Muscle, Skeletal - physiology</topic><topic>Renin-Angiotensin System - physiology</topic><topic>Risk Factors</topic><topic>Sarcopenia</topic><topic>Sarcopenia - pathology</topic><topic>Sarcopenia - urine</topic><topic>Urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mogi, Masaki</creatorcontrib><creatorcontrib>Kohara, Katsuhiko</creatorcontrib><creatorcontrib>Tabara, Yasuharu</creatorcontrib><creatorcontrib>Tsukuda, Kana</creatorcontrib><creatorcontrib>Igase, Michiya</creatorcontrib><creatorcontrib>Horiuchi, Masatsugu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Hypertension research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mogi, Masaki</au><au>Kohara, Katsuhiko</au><au>Tabara, Yasuharu</au><au>Tsukuda, Kana</au><au>Igase, Michiya</au><au>Horiuchi, Masatsugu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation between the 24-h urinary angiotensinogen or aldosterone level and muscle mass: Japan shimanami health promoting program study</atitle><jtitle>Hypertension research</jtitle><addtitle>Hypertens Res</addtitle><date>2018-05-01</date><risdate>2018</risdate><volume>41</volume><issue>5</issue><spage>326</spage><epage>333</epage><pages>326-333</pages><issn>0916-9636</issn><eissn>1348-4214</eissn><abstract>Our previous report indicated that sarcopenia is associated with arterial stiffness and cardiovascular death. The renin-angiotensin system (RAS) plays an important role in cardiovascular disease and its activation may be correlated with sarcopenia according to basic research. However, few clinical studies have assessed the correlation between skeletal muscle loss and RAS component concentrations in healthy subjects. The purpose of this study was to investigate the relationships between the excretion of angiotensinogen (AGT) and aldosterone (Ald) in 24-h urine samples and clinical and sarcopenic indices. A total of 344 people participated in a voluntary medical check-up program, "Anti-Aging Doc", and underwent measurement of their sarcopenia-related indices. Urine samples were collected for 24-h within 8 weeks after a medical check-up using a partition cup and a proportional sampling method. Urine AGT and Ald levels were evaluated by enzyme-linked immunosorbent assay (ELISA). After compensating for possible confounding parameters, including baPWV, the 24-h urinary excretion of AGT was independently and negatively associated with the thigh muscle cross-sectional area. On the other hand, urinary Ald excretion was not associated with sarcopenia-related indices after compensation, even though it showed a modest but significantly positive association with sarcopenic indices in single regression analysis. Urinary AGT was related to sarcopenic indices and may be involved in the pathogenesis of sarcopenia. On the other hand, urinary Ald was not related to sarcopenic indices when considering other risk factors.</abstract><cop>England</cop><pub>Nature Publishing Group</pub><pmid>29523869</pmid><doi>10.1038/s41440-018-0021-9</doi><tpages>8</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over Aldosterone - urine Anatomy, Cross-Sectional Angiotensinogen - urine Electric Impedance Female Hand Strength Health Promotion Healthy Aging Humans Japan Male Middle Aged Muscle, Skeletal - anatomy & histology Muscle, Skeletal - physiology Renin-Angiotensin System - physiology Risk Factors Sarcopenia Sarcopenia - pathology Sarcopenia - urine Urine |
| title | Correlation between the 24-h urinary angiotensinogen or aldosterone level and muscle mass: Japan shimanami health promoting program study |
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