The classroom microbiome and asthma morbidity in children attending 3 inner-city schools
To the Editor: School endotoxin exposure contributes to asthma morbidity.1 Recent shotgun metagenomics studies suggest that microbial identity, rather than microbial toxin levels alone, drives impacts of microbial exposure on chronic diseases.2 In this pilot randomized controlled trial of the effect...
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| Veröffentlicht in: | Journal of allergy and clinical immunology 2018-06, Vol.141 (6), p.2311-2313 |
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| container_end_page | 2313 |
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| container_issue | 6 |
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| container_title | Journal of allergy and clinical immunology |
| container_volume | 141 |
| creator | Lai, Peggy S. Kolde, Raivo Franzosa, Eric A. Gaffin, Jonathan M. Baxi, Sachin N. Sheehan, William J. Gold, Diane R. Gevers, Dirk Xavier, Ramnik J. Phipatanakul, Wanda |
| description | To the Editor: School endotoxin exposure contributes to asthma morbidity.1 Recent shotgun metagenomics studies suggest that microbial identity, rather than microbial toxin levels alone, drives impacts of microbial exposure on chronic diseases.2 In this pilot randomized controlled trial of the effect of school environmental interventions on indoor air quality and asthma symptoms, we sought to address 3 questions. [...]is the school microbial environment independently associated with asthma symptoms? [...]is the school microbiome modifiable? |
| doi_str_mv | 10.1016/j.jaci.2018.02.022 |
| format | Article |
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[...]is the school microbial environment independently associated with asthma symptoms? 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[...]is the school microbial environment independently associated with asthma symptoms? [...]is the school microbiome modifiable?</description><subject>Air Filters</subject><subject>Air Pollution, Indoor - adverse effects</subject><subject>Asthma</subject><subject>Asthma - epidemiology</subject><subject>Asthma - etiology</subject><subject>Bacteroides</subject><subject>Bacteroides dorei</subject><subject>Biosynthesis</subject><subject>Child</subject><subject>Children</subject><subject>Classrooms</subject><subject>Clinical trials</subject><subject>Cytokines</subject><subject>E coli</subject><subject>Enterobacter cloacae</subject><subject>Escherichia coli</subject><subject>Female</subject><subject>Humans</subject><subject>Indoor air quality</subject><subject>Intervention</subject><subject>Klebsiella oxytoca</subject><subject>Male</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Microbiota</subject><subject>Morbidity</subject><subject>Multiculturalism & pluralism</subject><subject>Pilot Projects</subject><subject>Schools</subject><subject>Serratia marcescens</subject><subject>Staphylococcus</subject><subject>Studies</subject><subject>Urban Population</subject><issn>0091-6749</issn><issn>1097-6825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhkVpaDYff6CHIOilF2-kkT8k6CUsbVpYyGUPuQlZHndlbCmR7ED-fWQ27aGHwsAg8cw7w0PIZ862nPH6dtgOxrotMC63DHLBB7LhTDVFLaH6SDaMKV7UTanOyUVKA8tvIdUncg6q4rIEuSGPhyNSO5qUYggTnZyNoXVhQmp8R02aj5OhU4it69z8Sp2n9ujGLqKnZp7Rd87_piL_e4yFXZFkjyGM6Yqc9WZMeP3eL8nhx_fD7mexf7j_tbvbFzbvnwsjJDM1YxIatE0-G_tKYgPQCcDcKwG8KWvRt7aVlmMlUFkB0Fhmqr4Ul-TrKfYphucF06wnlyyOo_EYlqSzHFBclKzO6Jd_0CEs0efjMlUqWSomVgpOVBaRpWCvn6KbTHzVnOlVux70qn1NlppBLshDN-_RSzth93fkj-cMfDsBmFW8OIw6WYfeYuci2ll3wf0v_w1lepKF</recordid><startdate>201806</startdate><enddate>201806</enddate><creator>Lai, Peggy S.</creator><creator>Kolde, Raivo</creator><creator>Franzosa, Eric A.</creator><creator>Gaffin, Jonathan M.</creator><creator>Baxi, Sachin N.</creator><creator>Sheehan, William J.</creator><creator>Gold, Diane R.</creator><creator>Gevers, Dirk</creator><creator>Xavier, Ramnik J.</creator><creator>Phipatanakul, Wanda</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9501-8606</orcidid></search><sort><creationdate>201806</creationdate><title>The classroom microbiome and asthma morbidity in children attending 3 inner-city schools</title><author>Lai, Peggy S. ; Kolde, Raivo ; Franzosa, Eric A. ; Gaffin, Jonathan M. ; Baxi, Sachin N. ; Sheehan, William J. ; Gold, Diane R. ; Gevers, Dirk ; Xavier, Ramnik J. ; Phipatanakul, Wanda</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-a380a600827ec7825ef58e722d32ee7253217463fbcb8c1e53e9c3227c0a5f43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Air Filters</topic><topic>Air Pollution, Indoor - adverse effects</topic><topic>Asthma</topic><topic>Asthma - epidemiology</topic><topic>Asthma - etiology</topic><topic>Bacteroides</topic><topic>Bacteroides dorei</topic><topic>Biosynthesis</topic><topic>Child</topic><topic>Children</topic><topic>Classrooms</topic><topic>Clinical trials</topic><topic>Cytokines</topic><topic>E coli</topic><topic>Enterobacter cloacae</topic><topic>Escherichia coli</topic><topic>Female</topic><topic>Humans</topic><topic>Indoor air quality</topic><topic>Intervention</topic><topic>Klebsiella oxytoca</topic><topic>Male</topic><topic>Metabolism</topic><topic>Metabolites</topic><topic>Microbiota</topic><topic>Morbidity</topic><topic>Multiculturalism & pluralism</topic><topic>Pilot Projects</topic><topic>Schools</topic><topic>Serratia marcescens</topic><topic>Staphylococcus</topic><topic>Studies</topic><topic>Urban Population</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lai, Peggy S.</creatorcontrib><creatorcontrib>Kolde, Raivo</creatorcontrib><creatorcontrib>Franzosa, Eric A.</creatorcontrib><creatorcontrib>Gaffin, Jonathan M.</creatorcontrib><creatorcontrib>Baxi, Sachin N.</creatorcontrib><creatorcontrib>Sheehan, William J.</creatorcontrib><creatorcontrib>Gold, Diane R.</creatorcontrib><creatorcontrib>Gevers, Dirk</creatorcontrib><creatorcontrib>Xavier, Ramnik J.</creatorcontrib><creatorcontrib>Phipatanakul, Wanda</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of allergy and clinical immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lai, Peggy S.</au><au>Kolde, Raivo</au><au>Franzosa, Eric A.</au><au>Gaffin, Jonathan M.</au><au>Baxi, Sachin N.</au><au>Sheehan, William J.</au><au>Gold, Diane R.</au><au>Gevers, Dirk</au><au>Xavier, Ramnik J.</au><au>Phipatanakul, Wanda</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The classroom microbiome and asthma morbidity in children attending 3 inner-city schools</atitle><jtitle>Journal of allergy and clinical immunology</jtitle><addtitle>J Allergy Clin Immunol</addtitle><date>2018-06</date><risdate>2018</risdate><volume>141</volume><issue>6</issue><spage>2311</spage><epage>2313</epage><pages>2311-2313</pages><issn>0091-6749</issn><eissn>1097-6825</eissn><abstract>To the Editor: School endotoxin exposure contributes to asthma morbidity.1 Recent shotgun metagenomics studies suggest that microbial identity, rather than microbial toxin levels alone, drives impacts of microbial exposure on chronic diseases.2 In this pilot randomized controlled trial of the effect of school environmental interventions on indoor air quality and asthma symptoms, we sought to address 3 questions. 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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Air Filters Air Pollution, Indoor - adverse effects Asthma Asthma - epidemiology Asthma - etiology Bacteroides Bacteroides dorei Biosynthesis Child Children Classrooms Clinical trials Cytokines E coli Enterobacter cloacae Escherichia coli Female Humans Indoor air quality Intervention Klebsiella oxytoca Male Metabolism Metabolites Microbiota Morbidity Multiculturalism & pluralism Pilot Projects Schools Serratia marcescens Staphylococcus Studies Urban Population |
| title | The classroom microbiome and asthma morbidity in children attending 3 inner-city schools |
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