Functional characterization of chicken TLR5 reveals species-specific recognition of flagellin

Mammalian Toll-like receptor 5 (TLR5) senses flagellin of several bacterial species and activates the innate immune system. The avian TLR repertoire exhibits considerable functional diversity compared to mammalian TLRs and evidence of a functional TLR5 in the avian species is lacking. In the present...

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Veröffentlicht in:	Molecular immunology 2008-03, Vol.45 (5), p.1298-1307
Hauptverfasser:	Keestra, A. Marijke, de Zoete, Marcel R., van Aubel, Rémon A.M.H., van Putten, Jos P.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Chicken Chickens Cloning, Molecular Evolution Flagellin Flagellin - metabolism Genetic Predisposition to Disease HeLa Cells Humans Molecular Sequence Data Mutation, Missense NF-kappa B - metabolism NF-κB Protein Binding - genetics Salmonella enterica Salmonella enteritidis - immunology Species Specificity Toll-like receptor Toll-Like Receptor 5 - genetics Toll-Like Receptor 5 - immunology Toll-Like Receptor 5 - metabolism Transfection
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