TET2-dependent IL-6 induction mediated by the tumor microenvironment promotes tumor metastasis in osteosarcoma

The tumor microenvironment promotes epigenetic changes in tumor cells associated with tumor aggressiveness. Here we report that in primary tumor cells, increased interleukin-6 ( IL-6 ) expression brought on by DNA demethylation of its promoter by ten-eleven translocation 2 (TET2) promotes lung metas...

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Veröffentlicht in:	Oncogene 2018-05, Vol.37 (22), p.2903-2920
Hauptverfasser:	Itoh, Hitoshi, Kadomatsu, Tsuyoshi, Tanoue, Hironori, Yugami, Masaki, Miyata, Keishi, Endo, Motoyoshi, Morinaga, Jun, Kobayashi, Eisuke, Miyamoto, Takeshi, Kurahashi, Ryoma, Terada, Kazutoyo, Mizuta, Hiroshi, Oike, Yuichi
Format:	Artikel
Sprache:	eng ; jpn
Schlagworte:	13/31 13/89 14/5 38/77 631/67/1344 631/67/327 64/60 82/1 Animals Apoptosis Bone cancer Bone Neoplasms - genetics Bone Neoplasms - metabolism Bone Neoplasms - pathology Care and treatment Cell adhesion Cell Biology Cell Line, Tumor Colonization Complications and side effects Demethylation Deoxyribonucleic acid Development and progression DNA DNA Methylation DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Epigenesis, Genetic Epigenetics Gene expression Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Genetic aspects Genotype Glycolysis Health aspects Human Genetics Humans Hypoxia Intercellular adhesion molecule 1 Intercellular Adhesion Molecule-1 - genetics Interleukin 6 Interleukin 6 receptors Interleukin-6 - genetics Interleukin-6 - metabolism Internal Medicine Lung cancer Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology Lung Neoplasms - secondary Lungs MAP Kinase Signaling System Medicine Medicine & Public Health Metastases Metastasis Mice Monoclonal antibodies Neoplasm Transplantation Oncology Osteosarcoma Osteosarcoma - genetics Osteosarcoma - metabolism Osteosarcoma - pathology Phenotypes Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Sarcoma Tumor cells Tumor Microenvironment Tumors Up-Regulation Xenografts
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