Fecal Fatty Acid Profiling as a Potential New Screening Biomarker in Patients with Colorectal Cancer
Background The fatty acid profile of the fecal metabolome and its association with colorectal cancer (CRC) has not been fully evaluated. Aims We aimed to compare the fecal fatty acid profiles of CRC patients and healthy controls. Methods We enrolled 26 newly diagnosed CRC patients and 28 healthy ind...
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| Veröffentlicht in: | Digestive diseases and sciences 2018-05, Vol.63 (5), p.1229-1236 |
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| container_title | Digestive diseases and sciences |
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| creator | Song, Eun Mi Byeon, Jeong-Sik Lee, Sun Mi Yoo, Hyun Ju Kim, Su Jung Lee, Sun-Ho Chang, Kiju Hwang, Sung Wook Yang, Dong-Hoon Jeong, Jin-Yong |
| description | Background
The fatty acid profile of the fecal metabolome and its association with colorectal cancer (CRC) has not been fully evaluated.
Aims
We aimed to compare the fecal fatty acid profiles of CRC patients and healthy controls.
Methods
We enrolled 26 newly diagnosed CRC patients and 28 healthy individuals between July 2014 and August 2014 from our institute. Long- and short-chain fatty acids were extracted from fecal samples and analyzed using gas chromatography–mass spectrometry.
Results
Regarding fecal long-chain fatty acids, the levels of total ω-6 polyunsaturated fatty acids and, particularly, of linoleic acid (C18:2ω-6) were significantly higher in male CRC patients than in healthy men (2.750 ± 2.583 vs. 1.254 ± 0.966 µg/mg feces,
P
= 0.040; 2.670 ± 2.507 vs. 1.226 ± 0.940 µg/mg feces,
P
= 0.034, respectively). In addition, the levels of total monounsaturated fatty acid and, particularly, of oleic acid (C18:1ω-9) were significantly higher in male CRC patients than in healthy men (1.802 ± 1.331 vs. 0.977 ± 0.625 µg/mg feces,
P
= 0.027; 1.749 ± 1.320 vs. 0.932 ± 0.626 µg/mg feces,
P
= 0.011, respectively). However, those differences were not shown in female gender. The level of fecal short-chain fatty acids was not different between CRC patients and healthy controls.
Conclusions
There were changes in the profiles of fecal fatty acid metabolomes in CRC patients compared to healthy controls, implying that fecal fatty acids could be used as a novel screening tool for CRC. |
| doi_str_mv | 10.1007/s10620-018-4982-y |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2012114990</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A712938162</galeid><sourcerecordid>A712938162</sourcerecordid><originalsourceid>FETCH-LOGICAL-c439t-f93b8074d9f89ca7710487011df0d6364aedd44f554a272d00976d9431f99fe43</originalsourceid><addsrcrecordid>eNp1kVFvVCEQhYmxsWv1B_hiSHzx5VbgcuHyuG5cNWnsJtVnQmFYqXehAptm_73cbLXR2PAwJOc7k5k5CL2i5JwSIt8VSgQjHaFjx9XIusMTtKCD7Ds2iPEpWhAq2p9ScYqel3JDCFGSimfolKmhSYwvkFuDNRNem1oPeGmDw5ucfJhC3GJTsMGbVCHW0JgvcIevbAaIs_g-pJ3JPyDjEPHG1NCogu9C_Y5XaUoZbG2elYkW8gt04s1U4OV9PUPf1h--rj51F5cfP6-WF53lvaqdV_31SCR3yo_KGikp4aMklDpPnOgFN-Ac534YuGGSuXkd4RTvqVfKA-_P0Ntj39ucfu6hVL0LxcI0mQhpXzQjtF2DK0Ua-uYf9Cbtc2zTzdTABWEDfaC2ZgIdok81Gzs31UtJmepHKlijzv9DtedgF2yK0O4Jfxvo0WBzKiWD17c5tGseNCV6TlYfk9UtWT0nqw_N8_p-4P31Dtwfx-8oG8COQGlS3EJ-2Ojxrr8AAwGrKw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2015460251</pqid></control><display><type>article</type><title>Fecal Fatty Acid Profiling as a Potential New Screening Biomarker in Patients with Colorectal Cancer</title><source>Springer Nature - Complete Springer Journals</source><creator>Song, Eun Mi ; Byeon, Jeong-Sik ; Lee, Sun Mi ; Yoo, Hyun Ju ; Kim, Su Jung ; Lee, Sun-Ho ; Chang, Kiju ; Hwang, Sung Wook ; Yang, Dong-Hoon ; Jeong, Jin-Yong</creator><creatorcontrib>Song, Eun Mi ; Byeon, Jeong-Sik ; Lee, Sun Mi ; Yoo, Hyun Ju ; Kim, Su Jung ; Lee, Sun-Ho ; Chang, Kiju ; Hwang, Sung Wook ; Yang, Dong-Hoon ; Jeong, Jin-Yong</creatorcontrib><description>Background
The fatty acid profile of the fecal metabolome and its association with colorectal cancer (CRC) has not been fully evaluated.
Aims
We aimed to compare the fecal fatty acid profiles of CRC patients and healthy controls.
Methods
We enrolled 26 newly diagnosed CRC patients and 28 healthy individuals between July 2014 and August 2014 from our institute. Long- and short-chain fatty acids were extracted from fecal samples and analyzed using gas chromatography–mass spectrometry.
Results
Regarding fecal long-chain fatty acids, the levels of total ω-6 polyunsaturated fatty acids and, particularly, of linoleic acid (C18:2ω-6) were significantly higher in male CRC patients than in healthy men (2.750 ± 2.583 vs. 1.254 ± 0.966 µg/mg feces,
P
= 0.040; 2.670 ± 2.507 vs. 1.226 ± 0.940 µg/mg feces,
P
= 0.034, respectively). In addition, the levels of total monounsaturated fatty acid and, particularly, of oleic acid (C18:1ω-9) were significantly higher in male CRC patients than in healthy men (1.802 ± 1.331 vs. 0.977 ± 0.625 µg/mg feces,
P
= 0.027; 1.749 ± 1.320 vs. 0.932 ± 0.626 µg/mg feces,
P
= 0.011, respectively). However, those differences were not shown in female gender. The level of fecal short-chain fatty acids was not different between CRC patients and healthy controls.
Conclusions
There were changes in the profiles of fecal fatty acid metabolomes in CRC patients compared to healthy controls, implying that fecal fatty acids could be used as a novel screening tool for CRC.</description><identifier>ISSN: 0163-2116</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1007/s10620-018-4982-y</identifier><identifier>PMID: 29516324</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Analysis ; Biochemistry ; Cancer ; Cancer patients ; Colorectal cancer ; Diagnosis ; Fatty acids ; Feces ; Gastroenterology ; Hepatology ; Mass spectrometry ; Medical screening ; Medicine ; Medicine & Public Health ; Metabolites ; Oncology ; Original Article ; Polyunsaturated fatty acids ; Transplant Surgery ; Unsaturated fatty acids</subject><ispartof>Digestive diseases and sciences, 2018-05, Vol.63 (5), p.1229-1236</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2018</rights><rights>COPYRIGHT 2018 Springer</rights><rights>Digestive Diseases and Sciences is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-f93b8074d9f89ca7710487011df0d6364aedd44f554a272d00976d9431f99fe43</citedby><cites>FETCH-LOGICAL-c439t-f93b8074d9f89ca7710487011df0d6364aedd44f554a272d00976d9431f99fe43</cites><orcidid>0000-0001-7756-2704</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10620-018-4982-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10620-018-4982-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29516324$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Song, Eun Mi</creatorcontrib><creatorcontrib>Byeon, Jeong-Sik</creatorcontrib><creatorcontrib>Lee, Sun Mi</creatorcontrib><creatorcontrib>Yoo, Hyun Ju</creatorcontrib><creatorcontrib>Kim, Su Jung</creatorcontrib><creatorcontrib>Lee, Sun-Ho</creatorcontrib><creatorcontrib>Chang, Kiju</creatorcontrib><creatorcontrib>Hwang, Sung Wook</creatorcontrib><creatorcontrib>Yang, Dong-Hoon</creatorcontrib><creatorcontrib>Jeong, Jin-Yong</creatorcontrib><title>Fecal Fatty Acid Profiling as a Potential New Screening Biomarker in Patients with Colorectal Cancer</title><title>Digestive diseases and sciences</title><addtitle>Dig Dis Sci</addtitle><addtitle>Dig Dis Sci</addtitle><description>Background
The fatty acid profile of the fecal metabolome and its association with colorectal cancer (CRC) has not been fully evaluated.
Aims
We aimed to compare the fecal fatty acid profiles of CRC patients and healthy controls.
Methods
We enrolled 26 newly diagnosed CRC patients and 28 healthy individuals between July 2014 and August 2014 from our institute. Long- and short-chain fatty acids were extracted from fecal samples and analyzed using gas chromatography–mass spectrometry.
Results
Regarding fecal long-chain fatty acids, the levels of total ω-6 polyunsaturated fatty acids and, particularly, of linoleic acid (C18:2ω-6) were significantly higher in male CRC patients than in healthy men (2.750 ± 2.583 vs. 1.254 ± 0.966 µg/mg feces,
P
= 0.040; 2.670 ± 2.507 vs. 1.226 ± 0.940 µg/mg feces,
P
= 0.034, respectively). In addition, the levels of total monounsaturated fatty acid and, particularly, of oleic acid (C18:1ω-9) were significantly higher in male CRC patients than in healthy men (1.802 ± 1.331 vs. 0.977 ± 0.625 µg/mg feces,
P
= 0.027; 1.749 ± 1.320 vs. 0.932 ± 0.626 µg/mg feces,
P
= 0.011, respectively). However, those differences were not shown in female gender. The level of fecal short-chain fatty acids was not different between CRC patients and healthy controls.
Conclusions
There were changes in the profiles of fecal fatty acid metabolomes in CRC patients compared to healthy controls, implying that fecal fatty acids could be used as a novel screening tool for CRC.</description><subject>Analysis</subject><subject>Biochemistry</subject><subject>Cancer</subject><subject>Cancer patients</subject><subject>Colorectal cancer</subject><subject>Diagnosis</subject><subject>Fatty acids</subject><subject>Feces</subject><subject>Gastroenterology</subject><subject>Hepatology</subject><subject>Mass spectrometry</subject><subject>Medical screening</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolites</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Polyunsaturated fatty acids</subject><subject>Transplant Surgery</subject><subject>Unsaturated fatty acids</subject><issn>0163-2116</issn><issn>1573-2568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp1kVFvVCEQhYmxsWv1B_hiSHzx5VbgcuHyuG5cNWnsJtVnQmFYqXehAptm_73cbLXR2PAwJOc7k5k5CL2i5JwSIt8VSgQjHaFjx9XIusMTtKCD7Ds2iPEpWhAq2p9ScYqel3JDCFGSimfolKmhSYwvkFuDNRNem1oPeGmDw5ucfJhC3GJTsMGbVCHW0JgvcIevbAaIs_g-pJ3JPyDjEPHG1NCogu9C_Y5XaUoZbG2elYkW8gt04s1U4OV9PUPf1h--rj51F5cfP6-WF53lvaqdV_31SCR3yo_KGikp4aMklDpPnOgFN-Ac534YuGGSuXkd4RTvqVfKA-_P0Ntj39ucfu6hVL0LxcI0mQhpXzQjtF2DK0Ua-uYf9Cbtc2zTzdTABWEDfaC2ZgIdok81Gzs31UtJmepHKlijzv9DtedgF2yK0O4Jfxvo0WBzKiWD17c5tGseNCV6TlYfk9UtWT0nqw_N8_p-4P31Dtwfx-8oG8COQGlS3EJ-2Ojxrr8AAwGrKw</recordid><startdate>20180501</startdate><enddate>20180501</enddate><creator>Song, Eun Mi</creator><creator>Byeon, Jeong-Sik</creator><creator>Lee, Sun Mi</creator><creator>Yoo, Hyun Ju</creator><creator>Kim, Su Jung</creator><creator>Lee, Sun-Ho</creator><creator>Chang, Kiju</creator><creator>Hwang, Sung Wook</creator><creator>Yang, Dong-Hoon</creator><creator>Jeong, Jin-Yong</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7756-2704</orcidid></search><sort><creationdate>20180501</creationdate><title>Fecal Fatty Acid Profiling as a Potential New Screening Biomarker in Patients with Colorectal Cancer</title><author>Song, Eun Mi ; Byeon, Jeong-Sik ; Lee, Sun Mi ; Yoo, Hyun Ju ; Kim, Su Jung ; Lee, Sun-Ho ; Chang, Kiju ; Hwang, Sung Wook ; Yang, Dong-Hoon ; Jeong, Jin-Yong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-f93b8074d9f89ca7710487011df0d6364aedd44f554a272d00976d9431f99fe43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Analysis</topic><topic>Biochemistry</topic><topic>Cancer</topic><topic>Cancer patients</topic><topic>Colorectal cancer</topic><topic>Diagnosis</topic><topic>Fatty acids</topic><topic>Feces</topic><topic>Gastroenterology</topic><topic>Hepatology</topic><topic>Mass spectrometry</topic><topic>Medical screening</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolites</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Polyunsaturated fatty acids</topic><topic>Transplant Surgery</topic><topic>Unsaturated fatty acids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Song, Eun Mi</creatorcontrib><creatorcontrib>Byeon, Jeong-Sik</creatorcontrib><creatorcontrib>Lee, Sun Mi</creatorcontrib><creatorcontrib>Yoo, Hyun Ju</creatorcontrib><creatorcontrib>Kim, Su Jung</creatorcontrib><creatorcontrib>Lee, Sun-Ho</creatorcontrib><creatorcontrib>Chang, Kiju</creatorcontrib><creatorcontrib>Hwang, Sung Wook</creatorcontrib><creatorcontrib>Yang, Dong-Hoon</creatorcontrib><creatorcontrib>Jeong, Jin-Yong</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Digestive diseases and sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Song, Eun Mi</au><au>Byeon, Jeong-Sik</au><au>Lee, Sun Mi</au><au>Yoo, Hyun Ju</au><au>Kim, Su Jung</au><au>Lee, Sun-Ho</au><au>Chang, Kiju</au><au>Hwang, Sung Wook</au><au>Yang, Dong-Hoon</au><au>Jeong, Jin-Yong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fecal Fatty Acid Profiling as a Potential New Screening Biomarker in Patients with Colorectal Cancer</atitle><jtitle>Digestive diseases and sciences</jtitle><stitle>Dig Dis Sci</stitle><addtitle>Dig Dis Sci</addtitle><date>2018-05-01</date><risdate>2018</risdate><volume>63</volume><issue>5</issue><spage>1229</spage><epage>1236</epage><pages>1229-1236</pages><issn>0163-2116</issn><eissn>1573-2568</eissn><abstract>Background
The fatty acid profile of the fecal metabolome and its association with colorectal cancer (CRC) has not been fully evaluated.
Aims
We aimed to compare the fecal fatty acid profiles of CRC patients and healthy controls.
Methods
We enrolled 26 newly diagnosed CRC patients and 28 healthy individuals between July 2014 and August 2014 from our institute. Long- and short-chain fatty acids were extracted from fecal samples and analyzed using gas chromatography–mass spectrometry.
Results
Regarding fecal long-chain fatty acids, the levels of total ω-6 polyunsaturated fatty acids and, particularly, of linoleic acid (C18:2ω-6) were significantly higher in male CRC patients than in healthy men (2.750 ± 2.583 vs. 1.254 ± 0.966 µg/mg feces,
P
= 0.040; 2.670 ± 2.507 vs. 1.226 ± 0.940 µg/mg feces,
P
= 0.034, respectively). In addition, the levels of total monounsaturated fatty acid and, particularly, of oleic acid (C18:1ω-9) were significantly higher in male CRC patients than in healthy men (1.802 ± 1.331 vs. 0.977 ± 0.625 µg/mg feces,
P
= 0.027; 1.749 ± 1.320 vs. 0.932 ± 0.626 µg/mg feces,
P
= 0.011, respectively). However, those differences were not shown in female gender. The level of fecal short-chain fatty acids was not different between CRC patients and healthy controls.
Conclusions
There were changes in the profiles of fecal fatty acid metabolomes in CRC patients compared to healthy controls, implying that fecal fatty acids could be used as a novel screening tool for CRC.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>29516324</pmid><doi>10.1007/s10620-018-4982-y</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-7756-2704</orcidid></addata></record> |
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| identifier | ISSN: 0163-2116 |
| ispartof | Digestive diseases and sciences, 2018-05, Vol.63 (5), p.1229-1236 |
| issn | 0163-2116 1573-2568 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2012114990 |
| source | Springer Nature - Complete Springer Journals |
| subjects | Analysis Biochemistry Cancer Cancer patients Colorectal cancer Diagnosis Fatty acids Feces Gastroenterology Hepatology Mass spectrometry Medical screening Medicine Medicine & Public Health Metabolites Oncology Original Article Polyunsaturated fatty acids Transplant Surgery Unsaturated fatty acids |
| title | Fecal Fatty Acid Profiling as a Potential New Screening Biomarker in Patients with Colorectal Cancer |
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