Stimulation of ACE2/ANG(1–7)/Mas Axis by Diminazene Ameliorates Alzheimer’s Disease in the D-Galactose-Ovariectomized Rat Model: Role of PI3K/Akt Pathway

Overactivation of angiotensin-converting enzyme/angiotensin 2/angiotensin receptor-1 (ACE/Ang2/AT1) axis provokes amyloid-β-induced apoptosis and neurodegeneration in Alzheimer’s disease (AD). Moreover, activation of AT1 impairs the survival pathway phosphoinositide 3-kinase/protein kinase B (PI3K/A...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular neurobiology 2018-10, Vol.55 (10), p.8188-8202
Hauptverfasser:	Kamel, Ahmed S., Abdelkader, Noha F., Abd El-Rahman, Sahar S., Emara, Marwan, Zaki, Hala F., Khattab, Mahmoud M.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase ACE2 AKT protein Alzheimer Disease - drug therapy Alzheimer Disease - genetics Alzheimer Disease - pathology Alzheimer Disease - physiopathology Alzheimer's disease Amyloid Angiotensin AT1 receptors Angiotensin I - metabolism Angiotensin-converting enzyme 2 Animals Apoptosis Apoptosis - drug effects Biomedical and Life Sciences Biomedicine Brain-derived neurotrophic factor Caspase-3 Cell Biology Cell Survival - drug effects Cognition - drug effects Cognitive ability Cyclic AMP Cytochrome c D-Galactose Diminazene - pharmacology Diminazene - therapeutic use Female Galactose Gene Expression Regulation - drug effects Glial fibrillary acidic protein Glial Fibrillary Acidic Protein - metabolism Glutamatergic transmission Glycogen Glycogen synthase Hippocampus Inflammation - pathology Kinases Learning Maze Learning - drug effects Memory Nerve Growth Factors - metabolism Neurobiology Neurodegeneration Neurology Neuronal Plasticity - drug effects Neuroplasticity Neurosciences Organelle Biogenesis Ovariectomy Peptide Fragments - metabolism Peptidyl-dipeptidase A Peptidyl-Dipeptidase A - metabolism Phosphatidylinositol 3-Kinases - metabolism Phosphorylation - drug effects Proteins Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-akt - metabolism Rats Rats, Wistar Receptors, G-Protein-Coupled - metabolism Receptors, Glutamate - metabolism Receptors, Nicotinic - metabolism Rodents Signal Transduction - drug effects Survival tau Proteins - metabolism Transcription
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!