Epigenetic reprogramming enables the transition from primordial germ cell to gonocyte

Gonadal germline epigenetic reprogramming involves an interplay between DNA methylation, the polycomb complex and Tet1 in both DNA methylation dependent and independent roles, to ensure the activation of a specific subset of genes critical for progression of gametogenesis. Epigenetic reprogramming i...

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Veröffentlicht in:	Nature (London) 2018-03, Vol.555 (7696), p.392-396
Hauptverfasser:	Hill, Peter W. S., Leitch, Harry G., Requena, Cristina E., Sun, Zhiyi, Amouroux, Rachel, Roman-Trufero, Monica, Borkowska, Malgorzata, Terragni, Jolyon, Vaisvila, Romualdas, Linnett, Sarah, Bagci, Hakan, Dharmalingham, Gopuraja, Haberle, Vanja, Lenhard, Boris, Zheng, Yu, Pradhan, Sriharsa, Hajkova, Petra
Format:	Artikel
Sprache:	eng
Schlagworte:	13/100 13/106 13/51 38/15 38/91 45/22 45/77 5-Methylcytosine - analogs & derivatives 5-Methylcytosine - metabolism 631/136/2434 631/136/2435 631/208/176/1988 631/208/177 64/60 Animals Cell differentiation Cellular Reprogramming - genetics Cytological research Demethylation Deoxyribonucleic acid DNA DNA Methylation DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Embryos Epigenesis, Genetic Epigenetic inheritance Epigenetics Experiments Female Gametes Gametogenesis Gametogenesis - genetics Gene expression Genetic aspects Genomes Germ cells Germ Cells - cytology Germ Cells - metabolism Humanities and Social Sciences Laboratories letter Localization Male Meiosis Mice Molecular modelling multidisciplinary Nuclear reprogramming Nucleotide sequence Polycomb group proteins Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism RNA polymerase Science Stem cells
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