The protective effects of metformin in an in vitro model of aging 3T3 fibroblast under the high glucose conditions

Metformin is the most widely used anti-diabetic drug in the world. It reduces advanced glycation end product (AGEs)-induced ROS generation in high glucose condition. Protein glycation contributes to skin aging as it deteriorates the existing collagen by crosslinking. The progressive increase of AGE...

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Veröffentlicht in:	Journal of physiology and biochemistry 2018-05, Vol.74 (2), p.273-281
Hauptverfasser:	Soydas, Tugba, Yaprak Sarac, Elif, Cinar, Suzan, Dogan, Sibel, Solakoglu, Seyhun, Tuncdemir, Matem, Kanigur Sultuybek, Gonul
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Aging Animal Physiology Animals Apoptosis Apoptosis - drug effects Assaying Biomedical and Life Sciences Biomedicine Cell growth Cell proliferation Cell Proliferation - drug effects Cellular Senescence - drug effects Collagen Collagen (type I) Collagen Type I - biosynthesis Collagen Type I - metabolism Collagen Type III - biosynthesis Collagen Type III - metabolism Crosslinking Culture Media Diabetes mellitus Enzyme-Linked Immunosorbent Assay Fibroblasts Flow cytometry Glucose Glucose - administration & dosage Glycosylation Human Physiology Hyperglycemia - drug therapy Hypoglycemic Agents - pharmacology Hypoglycemic Agents - therapeutic use Macromolecules Metformin Metformin - pharmacology Metformin - therapeutic use Mice NF-κB protein Original Article Proteins Reactive oxygen species Skin Transcription activation Transcription Factor RelA - metabolism Transcription factors
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