Characterization of ELISA Antibody-Antigen Interaction using Footprinting-Mass Spectrometry and Negative Staining Transmission Electron Microscopy

We describe epitope mapping data using multiple covalent labeling footprinting-mass spectrometry (MS) techniques coupled with negative stain transmission electron microscopy (TEM) data to analyze the antibody–antigen interactions in a sandwich enzyme-linked immunosorbant assay (ELISA). Our hydroxyl...

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Veröffentlicht in:	Journal of the American Society for Mass Spectrometry 2018-05, Vol.29 (5), p.961-971
Hauptverfasser:	Lin, Margaret, Krawitz, Denise, Callahan, Matthew D., Deperalta, Galahad, Wecksler, Aaron T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical Chemistry Antigens Binding Bioinformatics Biotechnology Carboxyl group Chemistry Chemistry and Materials Science Crystal structure Data analysis Diamonds Glycine Hydroxyl radicals Labeling Mapping Mass spectrometry Monoclonal antibodies Organic Chemistry Oxidation Proteins Proteomics Quality control Reagents Research Article Scientific imaging Spectroscopy Transmission electron microscopy
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