The use of selective estrogen receptor modulators on bone health in men
Selective estrogen receptor modulators (SERMs) represent a class of drugs that act as agonist or antagonist for estrogen receptor in a tissue-specific manner. The SERMs drugs are initially used for the prevention and treatment of osteoporosis in postmenopausal women. Bone health in prostate cancer p...
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| Veröffentlicht in: | The aging male 2019-04, Vol.22 (2), p.89-101 |
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| container_title | The aging male |
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| creator | Wong, Sok Kuan Mohamad, Nur-Vaizura Jayusman, Putri Ayu Shuid, Ahmad Nazrun Ima-Nirwana, Soelaiman Chin, Kok-Yong |
| description | Selective estrogen receptor modulators (SERMs) represent a class of drugs that act as agonist or antagonist for estrogen receptor in a tissue-specific manner. The SERMs drugs are initially used for the prevention and treatment of osteoporosis in postmenopausal women. Bone health in prostate cancer patients has become a significant concern, whereby patients undergo androgen deprivation therapy is often associated with deleterious effects on bone. Previous preclinical and epidemiological findings showed that estrogens play a dominant role in improving bone health as compared to testosterone in men. Therefore, this evidence-based review aims to assess the available evidence derived from animal and human studies on the effects of SERMs on the male skeletal system. The effects of SERMs on bone mineral density (BMD)/content (BMC), bone histomorphometry, bone turnover, bone strength and fracture risk have been summarized in this review. |
| doi_str_mv | 10.1080/13685538.2018.1448058 |
| format | Article |
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The effects of SERMs on bone mineral density (BMD)/content (BMC), bone histomorphometry, bone turnover, bone strength and fracture risk have been summarized in this review.</description><subject>Bone density</subject><subject>Bones</subject><subject>Estrogens</subject><subject>lasofoxifene</subject><subject>Mens health</subject><subject>Older people</subject><subject>Osteoporosis</subject><subject>Prostate cancer</subject><subject>raloxifene</subject><subject>tamoxifen</subject><subject>toremifene</subject><issn>1368-5538</issn><issn>1473-0790</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kLtOwzAUhi0E4lJ4BJAlFpYUX2N3AyFuEhJLmS0nOaapErvYCYi3x1VbBgYmn-E7v__zIXROyZQSTa4pL7WUXE8ZoXpKhdBE6j10TIXiBVEzsp_nzBRr6AidpLQkhDKl1CE6YjNJdCnIMXqcLwCPCXBwOEEH9dB-AoY0xPAOHkeoYTWEiPvQjJ3NU8LB4yp4wAuw3bDArcc9-FN04GyX4Gz7TtDbw_387ql4eX18vrt9KWo-E0NBS1dSZqlVDaurhguoSutyRQkMlHKSE-Y041xTcLTWmlfENVoyLWesoSWfoKtN7iqGjzH3NH2baug66yGMyWQb-UjJqcro5R90GcboczvDGMuKBBE6U3JD1TGkFMGZVWx7G78NJWZt2uxMr7O12ZrOexfb9LHqofnd2qnNwM0GaL0LsbdfIXaNGex3F6KL1tdtMvz_P34AMsiLTA</recordid><startdate>20190403</startdate><enddate>20190403</enddate><creator>Wong, Sok Kuan</creator><creator>Mohamad, Nur-Vaizura</creator><creator>Jayusman, Putri Ayu</creator><creator>Shuid, Ahmad Nazrun</creator><creator>Ima-Nirwana, Soelaiman</creator><creator>Chin, Kok-Yong</creator><general>Taylor & Francis</general><general>Taylor & Francis Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6628-1552</orcidid><orcidid>https://orcid.org/0000-0003-1184-4551</orcidid></search><sort><creationdate>20190403</creationdate><title>The use of selective estrogen receptor modulators on bone health in men</title><author>Wong, Sok Kuan ; Mohamad, Nur-Vaizura ; Jayusman, Putri Ayu ; Shuid, Ahmad Nazrun ; Ima-Nirwana, Soelaiman ; Chin, Kok-Yong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c394t-16f612a1a7d2cbd34eb6af5535e2e77f5302f823381ef1c883b0fd8528592d163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Bone density</topic><topic>Bones</topic><topic>Estrogens</topic><topic>lasofoxifene</topic><topic>Mens health</topic><topic>Older people</topic><topic>Osteoporosis</topic><topic>Prostate cancer</topic><topic>raloxifene</topic><topic>tamoxifen</topic><topic>toremifene</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wong, Sok Kuan</creatorcontrib><creatorcontrib>Mohamad, Nur-Vaizura</creatorcontrib><creatorcontrib>Jayusman, Putri Ayu</creatorcontrib><creatorcontrib>Shuid, Ahmad Nazrun</creatorcontrib><creatorcontrib>Ima-Nirwana, Soelaiman</creatorcontrib><creatorcontrib>Chin, Kok-Yong</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>The aging male</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wong, Sok Kuan</au><au>Mohamad, Nur-Vaizura</au><au>Jayusman, Putri Ayu</au><au>Shuid, Ahmad Nazrun</au><au>Ima-Nirwana, Soelaiman</au><au>Chin, Kok-Yong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The use of selective estrogen receptor modulators on bone health in men</atitle><jtitle>The aging male</jtitle><addtitle>Aging Male</addtitle><date>2019-04-03</date><risdate>2019</risdate><volume>22</volume><issue>2</issue><spage>89</spage><epage>101</epage><pages>89-101</pages><issn>1368-5538</issn><eissn>1473-0790</eissn><abstract>Selective estrogen receptor modulators (SERMs) represent a class of drugs that act as agonist or antagonist for estrogen receptor in a tissue-specific manner. The SERMs drugs are initially used for the prevention and treatment of osteoporosis in postmenopausal women. Bone health in prostate cancer patients has become a significant concern, whereby patients undergo androgen deprivation therapy is often associated with deleterious effects on bone. Previous preclinical and epidemiological findings showed that estrogens play a dominant role in improving bone health as compared to testosterone in men. Therefore, this evidence-based review aims to assess the available evidence derived from animal and human studies on the effects of SERMs on the male skeletal system. 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| ispartof | The aging male, 2019-04, Vol.22 (2), p.89-101 |
| issn | 1368-5538 1473-0790 |
| language | eng |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Bone density Bones Estrogens lasofoxifene Mens health Older people Osteoporosis Prostate cancer raloxifene tamoxifen toremifene |
| title | The use of selective estrogen receptor modulators on bone health in men |
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