Trabecular bone microstructure and mineral density in human residual ridge at various intervals over a long period after tooth extraction

Background Long‐term changes of trabecular microstructure in human tooth extraction socket have not been investigated. Purpose To examine the trabecular microstructure of human residual ridges at various intervals following tooth extraction, and to determine whether bone remodeling activity can atta...

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Veröffentlicht in:Clinical implant dentistry and related research 2018-06, Vol.20 (3), p.375-383
Hauptverfasser: Tanaka, Mikako, Yamashita‐Mikami, Emi, Akazawa, Kohei, Yoshizawa, Michiko, Arai, Yoshiaki, Ejiri, Sadakazu
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container_issue 3
container_start_page 375
container_title Clinical implant dentistry and related research
container_volume 20
creator Tanaka, Mikako
Yamashita‐Mikami, Emi
Akazawa, Kohei
Yoshizawa, Michiko
Arai, Yoshiaki
Ejiri, Sadakazu
description Background Long‐term changes of trabecular microstructure in human tooth extraction socket have not been investigated. Purpose To examine the trabecular microstructure of human residual ridges at various intervals following tooth extraction, and to determine whether bone remodeling activity can attain points of relative stability and when such points are reached. Materials and Methods Forty‐four bone biopsy specimens were obtained from lower molar or premolar regions of residual ridges. Postextraction times ranged from 1.6 to 360 months. Samples were analyzed using micro‐computed tomography and three‐dimensional bone morphometry with histological analyses. Trabecular bone parameters were plotted against postextraction times, and a stepwise piecewise linear regression analysis was performed to determine at which points of time these parameters either increased or decreased. Results Using piecewise linear regression, “inflection points” were found in most trabecular bone parameters between 7 and 12 months postextraction. Among the residual ridge samples, woven trabecular structure became mature, consisting of thick lamellar trabeculae with sufficient bone density, under dynamic bone remodeling until the 7th to 12th month post‐tooth extraction. After this period, the mature network structure remained stable with low remodeling activity. Conclusion Bone remodeling of trabecular structure in human residual ridge after tooth extraction had a stabilization period.
doi_str_mv 10.1111/cid.12591
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Purpose To examine the trabecular microstructure of human residual ridges at various intervals following tooth extraction, and to determine whether bone remodeling activity can attain points of relative stability and when such points are reached. Materials and Methods Forty‐four bone biopsy specimens were obtained from lower molar or premolar regions of residual ridges. Postextraction times ranged from 1.6 to 360 months. Samples were analyzed using micro‐computed tomography and three‐dimensional bone morphometry with histological analyses. Trabecular bone parameters were plotted against postextraction times, and a stepwise piecewise linear regression analysis was performed to determine at which points of time these parameters either increased or decreased. Results Using piecewise linear regression, “inflection points” were found in most trabecular bone parameters between 7 and 12 months postextraction. Among the residual ridge samples, woven trabecular structure became mature, consisting of thick lamellar trabeculae with sufficient bone density, under dynamic bone remodeling until the 7th to 12th month post‐tooth extraction. After this period, the mature network structure remained stable with low remodeling activity. Conclusion Bone remodeling of trabecular structure in human residual ridge after tooth extraction had a stabilization period.</description><identifier>ISSN: 1523-0899</identifier><identifier>EISSN: 1708-8208</identifier><identifier>DOI: 10.1111/cid.12591</identifier><identifier>PMID: 29508527</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adult ; Aged ; Bicuspid - pathology ; Biopsy ; Bone Density ; bone microstructure ; Bone mineral density ; Bone Remodeling ; Cancellous bone ; Cancellous Bone - chemistry ; Cancellous Bone - pathology ; Cancellous Bone - ultrastructure ; Computed tomography ; Dentistry ; Female ; human mandible ; Humans ; Imaging, Three-Dimensional ; Inflection points ; Intervals ; Lamellar bone ; Lamellar structure ; Linear Models ; Male ; microCT ; Microstructure ; Middle Aged ; Minerals - analysis ; Molar - pathology ; Morphometry ; Parameters ; Regression analysis ; residual ridge ; Teeth ; Time Factors ; Tooth Extraction ; tooth extraction sockets ; Tooth extractions ; Tooth Socket - pathology ; X-Ray Microtomography ; Young Adult</subject><ispartof>Clinical implant dentistry and related research, 2018-06, Vol.20 (3), p.375-383</ispartof><rights>2018 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4191-8a24e3c6a29a59d61c46ee2ed2d146d4187b3dee345f8d35f15da5124c2faf5f3</citedby><cites>FETCH-LOGICAL-c4191-8a24e3c6a29a59d61c46ee2ed2d146d4187b3dee345f8d35f15da5124c2faf5f3</cites><orcidid>0000-0002-3850-9385</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fcid.12591$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fcid.12591$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29508527$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tanaka, Mikako</creatorcontrib><creatorcontrib>Yamashita‐Mikami, Emi</creatorcontrib><creatorcontrib>Akazawa, Kohei</creatorcontrib><creatorcontrib>Yoshizawa, Michiko</creatorcontrib><creatorcontrib>Arai, Yoshiaki</creatorcontrib><creatorcontrib>Ejiri, Sadakazu</creatorcontrib><title>Trabecular bone microstructure and mineral density in human residual ridge at various intervals over a long period after tooth extraction</title><title>Clinical implant dentistry and related research</title><addtitle>Clin Implant Dent Relat Res</addtitle><description>Background Long‐term changes of trabecular microstructure in human tooth extraction socket have not been investigated. Purpose To examine the trabecular microstructure of human residual ridges at various intervals following tooth extraction, and to determine whether bone remodeling activity can attain points of relative stability and when such points are reached. Materials and Methods Forty‐four bone biopsy specimens were obtained from lower molar or premolar regions of residual ridges. Postextraction times ranged from 1.6 to 360 months. Samples were analyzed using micro‐computed tomography and three‐dimensional bone morphometry with histological analyses. Trabecular bone parameters were plotted against postextraction times, and a stepwise piecewise linear regression analysis was performed to determine at which points of time these parameters either increased or decreased. Results Using piecewise linear regression, “inflection points” were found in most trabecular bone parameters between 7 and 12 months postextraction. Among the residual ridge samples, woven trabecular structure became mature, consisting of thick lamellar trabeculae with sufficient bone density, under dynamic bone remodeling until the 7th to 12th month post‐tooth extraction. After this period, the mature network structure remained stable with low remodeling activity. 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Yamashita‐Mikami, Emi ; Akazawa, Kohei ; Yoshizawa, Michiko ; Arai, Yoshiaki ; Ejiri, Sadakazu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4191-8a24e3c6a29a59d61c46ee2ed2d146d4187b3dee345f8d35f15da5124c2faf5f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Bicuspid - pathology</topic><topic>Biopsy</topic><topic>Bone Density</topic><topic>bone microstructure</topic><topic>Bone mineral density</topic><topic>Bone Remodeling</topic><topic>Cancellous bone</topic><topic>Cancellous Bone - chemistry</topic><topic>Cancellous Bone - pathology</topic><topic>Cancellous Bone - ultrastructure</topic><topic>Computed tomography</topic><topic>Dentistry</topic><topic>Female</topic><topic>human mandible</topic><topic>Humans</topic><topic>Imaging, Three-Dimensional</topic><topic>Inflection points</topic><topic>Intervals</topic><topic>Lamellar bone</topic><topic>Lamellar structure</topic><topic>Linear Models</topic><topic>Male</topic><topic>microCT</topic><topic>Microstructure</topic><topic>Middle Aged</topic><topic>Minerals - analysis</topic><topic>Molar - pathology</topic><topic>Morphometry</topic><topic>Parameters</topic><topic>Regression analysis</topic><topic>residual ridge</topic><topic>Teeth</topic><topic>Time Factors</topic><topic>Tooth Extraction</topic><topic>tooth extraction sockets</topic><topic>Tooth extractions</topic><topic>Tooth Socket - pathology</topic><topic>X-Ray Microtomography</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tanaka, Mikako</creatorcontrib><creatorcontrib>Yamashita‐Mikami, Emi</creatorcontrib><creatorcontrib>Akazawa, Kohei</creatorcontrib><creatorcontrib>Yoshizawa, Michiko</creatorcontrib><creatorcontrib>Arai, Yoshiaki</creatorcontrib><creatorcontrib>Ejiri, Sadakazu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical implant dentistry and related research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tanaka, Mikako</au><au>Yamashita‐Mikami, Emi</au><au>Akazawa, Kohei</au><au>Yoshizawa, Michiko</au><au>Arai, Yoshiaki</au><au>Ejiri, Sadakazu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Trabecular bone microstructure and mineral density in human residual ridge at various intervals over a long period after tooth extraction</atitle><jtitle>Clinical implant dentistry and related research</jtitle><addtitle>Clin Implant Dent Relat Res</addtitle><date>2018-06</date><risdate>2018</risdate><volume>20</volume><issue>3</issue><spage>375</spage><epage>383</epage><pages>375-383</pages><issn>1523-0899</issn><eissn>1708-8208</eissn><abstract>Background Long‐term changes of trabecular microstructure in human tooth extraction socket have not been investigated. Purpose To examine the trabecular microstructure of human residual ridges at various intervals following tooth extraction, and to determine whether bone remodeling activity can attain points of relative stability and when such points are reached. Materials and Methods Forty‐four bone biopsy specimens were obtained from lower molar or premolar regions of residual ridges. Postextraction times ranged from 1.6 to 360 months. Samples were analyzed using micro‐computed tomography and three‐dimensional bone morphometry with histological analyses. Trabecular bone parameters were plotted against postextraction times, and a stepwise piecewise linear regression analysis was performed to determine at which points of time these parameters either increased or decreased. Results Using piecewise linear regression, “inflection points” were found in most trabecular bone parameters between 7 and 12 months postextraction. Among the residual ridge samples, woven trabecular structure became mature, consisting of thick lamellar trabeculae with sufficient bone density, under dynamic bone remodeling until the 7th to 12th month post‐tooth extraction. After this period, the mature network structure remained stable with low remodeling activity. Conclusion Bone remodeling of trabecular structure in human residual ridge after tooth extraction had a stabilization period.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29508527</pmid><doi>10.1111/cid.12591</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-3850-9385</orcidid></addata></record>
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source MEDLINE; Access via Wiley Online Library
subjects Adult
Aged
Bicuspid - pathology
Biopsy
Bone Density
bone microstructure
Bone mineral density
Bone Remodeling
Cancellous bone
Cancellous Bone - chemistry
Cancellous Bone - pathology
Cancellous Bone - ultrastructure
Computed tomography
Dentistry
Female
human mandible
Humans
Imaging, Three-Dimensional
Inflection points
Intervals
Lamellar bone
Lamellar structure
Linear Models
Male
microCT
Microstructure
Middle Aged
Minerals - analysis
Molar - pathology
Morphometry
Parameters
Regression analysis
residual ridge
Teeth
Time Factors
Tooth Extraction
tooth extraction sockets
Tooth extractions
Tooth Socket - pathology
X-Ray Microtomography
Young Adult
title Trabecular bone microstructure and mineral density in human residual ridge at various intervals over a long period after tooth extraction
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