Fragment Based Optimization of Metabotropic Glutamate Receptor 2 (mGluR2) Positive Allosteric Modulators in the Absence of Structural Information

Metabotropic glutamate receptor 2 (mGluR2) positive allosteric modulators (PAMs) have been implicated as potential pharmacotherapy for psychiatric conditions. Screening our corporate compound deck, we identified a benzotriazole fragment (4) that was rapidly optimized to a potent and metabolically st...

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Veröffentlicht in:	Journal of medicinal chemistry 2019-01, Vol.62 (1), p.234-246
Hauptverfasser:	Szabó, György, Túrós, György I, Kolok, Sándor, Vastag, Mónika, Sánta, Zsuzsanna, Dékány, Miklós, Lévay, György I, Greiner, István, Natsumi, Minami, Tatsuya, Watanabe, Keserű, György M
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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