Reduced brain volumes in children of women with epilepsy: A neuropsychological and voxel based morphometric analysis in pre-adolescent children
•Mean FSIQ was lower in children with antenatal AED exposure (CAED) compared to controls (P=0.001)•CAED had also significantly reduced TBV,GMV (P
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| Veröffentlicht in: | Journal of neuroradiology 2018-10, Vol.45 (6), p.380-385 |
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| container_title | Journal of neuroradiology |
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| creator | Sreedharan, R.M. Sheelakumari, R. Anila, K.M. Kesavadas, C. Thomas, S.V. |
| description | •Mean FSIQ was lower in children with antenatal AED exposure (CAED) compared to controls (P=0.001)•CAED had also significantly reduced TBV,GMV (P |
| doi_str_mv | 10.1016/j.neurad.2018.02.005 |
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Children of Women with Epilepsy with antenatal exposure to antiepileptic drugs (CAED) have reduced neuropsychological functions. We aimed to explore the anatomical basis for this impairment by comparing the brain volumes of CAED with that of matched healthy children without antenatal AED exposure (COAED).
CAED aged 8–12 years were recruited from the Kerala Registry of epilepsy and pregnancy that prospectively follows up children of women with epilepsy and COAED from children attending the imaging department for minor illnesses. Maternal clinical details and the neuropsychological data including IQ of CAED and COAED were obtained. Total intracranial volume (TBV), grey matter volume (GMV), white matter volume (WMV) and volumes of deep grey matter were measured by Voxel Based Morphometry.
We studied 30 CAED (mean age 10.8+1.11 years) and 35 COAED (mean age 10.64+1.26). The antenatal AED exposure for the CAED was monotherapy for 8 children and polytherapy for 22 children. The CAED had significantly lower (P<0.001) IQ (77.5+13.8), TBV(1259.55±169.85mL) and GMV (672.51±85.42 mL) compared to the IQ (87.0+13.5), TBV(1405.37±161mL) and GMV (745.427±86.69 mL) of COAED. CAED had lower volumes for Lt Inferior Triangular Gyrus, and hippocampi on both sides, when compared to COAED. Group analysis CAED showed less GMV (P<0.05) for left inferior and middle frontal gyri relative to COAED.
These observations point towards an anatomical basis of lower GMV for the lower neuropsychological functions in children with antenatal AED exposure.</description><identifier>ISSN: 0150-9861</identifier><identifier>DOI: 10.1016/j.neurad.2018.02.005</identifier><identifier>PMID: 29505839</identifier><language>eng</language><publisher>France: Elsevier Masson SAS</publisher><subject>Anticonvulsants - adverse effects ; Antiepileptic drugs ; Brain - drug effects ; Brain - pathology ; Child ; Children of woman with epilepsy ; Epilepsy - drug therapy ; Female ; Gray Matter - drug effects ; Gray Matter - pathology ; Grey matter volume ; Humans ; Male ; Neuropsychological Tests ; Pregnancy ; Prenatal Exposure Delayed Effects ; Total intracranial volume ; Voxel based morphometry ; White Matter - drug effects ; White Matter - pathology ; White matter volume</subject><ispartof>Journal of neuroradiology, 2018-10, Vol.45 (6), p.380-385</ispartof><rights>2018 Elsevier Masson SAS</rights><rights>Copyright © 2018 Elsevier Masson SAS. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-8c7ac2e24a780b9a84d809581a8fecc760b7d6cd423824af26ca9810e8a91b103</citedby><cites>FETCH-LOGICAL-c362t-8c7ac2e24a780b9a84d809581a8fecc760b7d6cd423824af26ca9810e8a91b103</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neurad.2018.02.005$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29505839$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sreedharan, R.M.</creatorcontrib><creatorcontrib>Sheelakumari, R.</creatorcontrib><creatorcontrib>Anila, K.M.</creatorcontrib><creatorcontrib>Kesavadas, C.</creatorcontrib><creatorcontrib>Thomas, S.V.</creatorcontrib><title>Reduced brain volumes in children of women with epilepsy: A neuropsychological and voxel based morphometric analysis in pre-adolescent children</title><title>Journal of neuroradiology</title><addtitle>J Neuroradiol</addtitle><description>•Mean FSIQ was lower in children with antenatal AED exposure (CAED) compared to controls (P=0.001)•CAED had also significantly reduced TBV,GMV (P<0.001)•Mean CSF volume was significantly larger for the CAED group (P<0.001)
Children of Women with Epilepsy with antenatal exposure to antiepileptic drugs (CAED) have reduced neuropsychological functions. We aimed to explore the anatomical basis for this impairment by comparing the brain volumes of CAED with that of matched healthy children without antenatal AED exposure (COAED).
CAED aged 8–12 years were recruited from the Kerala Registry of epilepsy and pregnancy that prospectively follows up children of women with epilepsy and COAED from children attending the imaging department for minor illnesses. Maternal clinical details and the neuropsychological data including IQ of CAED and COAED were obtained. Total intracranial volume (TBV), grey matter volume (GMV), white matter volume (WMV) and volumes of deep grey matter were measured by Voxel Based Morphometry.
We studied 30 CAED (mean age 10.8+1.11 years) and 35 COAED (mean age 10.64+1.26). The antenatal AED exposure for the CAED was monotherapy for 8 children and polytherapy for 22 children. The CAED had significantly lower (P<0.001) IQ (77.5+13.8), TBV(1259.55±169.85mL) and GMV (672.51±85.42 mL) compared to the IQ (87.0+13.5), TBV(1405.37±161mL) and GMV (745.427±86.69 mL) of COAED. CAED had lower volumes for Lt Inferior Triangular Gyrus, and hippocampi on both sides, when compared to COAED. Group analysis CAED showed less GMV (P<0.05) for left inferior and middle frontal gyri relative to COAED.
These observations point towards an anatomical basis of lower GMV for the lower neuropsychological functions in children with antenatal AED exposure.</description><subject>Anticonvulsants - adverse effects</subject><subject>Antiepileptic drugs</subject><subject>Brain - drug effects</subject><subject>Brain - pathology</subject><subject>Child</subject><subject>Children of woman with epilepsy</subject><subject>Epilepsy - drug therapy</subject><subject>Female</subject><subject>Gray Matter - drug effects</subject><subject>Gray Matter - pathology</subject><subject>Grey matter volume</subject><subject>Humans</subject><subject>Male</subject><subject>Neuropsychological Tests</subject><subject>Pregnancy</subject><subject>Prenatal Exposure Delayed Effects</subject><subject>Total intracranial volume</subject><subject>Voxel based morphometry</subject><subject>White Matter - drug effects</subject><subject>White Matter - pathology</subject><subject>White matter volume</subject><issn>0150-9861</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UctO3DAU9aIVM4X-QYW87CbptfNyWFRCiJZKSEgI1pZj33Q8cuLUThjmK_rLeDrAsqt7pHse18eEfGGQM2D1t20-4hKUyTkwkQPPAaoPZA2sgqwVNVuRTzFuAThjJT8hK95WUImiXZO_92gWjYZ2QdmRPnm3DBhpgnpjnQk4Ut_TnR8S2Nl5Q3GyDqe4v6CX9BDqE9Yb7_xvq5WjajTJ5Bkd7VRMtoMP0yap52B1Wiq3j_af_RQwU8Y7jBrH-T3tjHzslYv4-XWekscf1w9XN9nt3c9fV5e3mS5qPmdCN0pz5KVqBHStEqUR0FaCKdGj1k0NXWNqbUpeiETqea1VKxigUC3rGBSn5OvRdwr-z4JxloNNlzinRvRLlKlIxhteNG2ilkeqDj7GgL2cgh1U2EsG8lC_3Mpj_QeVkMBlqj_Jzl8Tlm5A8y566z4Rvh8JmN75ZDHIqC2O6TNsQD1L4-3_E14AFmadlA</recordid><startdate>201810</startdate><enddate>201810</enddate><creator>Sreedharan, R.M.</creator><creator>Sheelakumari, R.</creator><creator>Anila, K.M.</creator><creator>Kesavadas, C.</creator><creator>Thomas, S.V.</creator><general>Elsevier Masson SAS</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201810</creationdate><title>Reduced brain volumes in children of women with epilepsy: A neuropsychological and voxel based morphometric analysis in pre-adolescent children</title><author>Sreedharan, R.M. ; Sheelakumari, R. ; Anila, K.M. ; Kesavadas, C. ; Thomas, S.V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-8c7ac2e24a780b9a84d809581a8fecc760b7d6cd423824af26ca9810e8a91b103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Anticonvulsants - adverse effects</topic><topic>Antiepileptic drugs</topic><topic>Brain - drug effects</topic><topic>Brain - pathology</topic><topic>Child</topic><topic>Children of woman with epilepsy</topic><topic>Epilepsy - drug therapy</topic><topic>Female</topic><topic>Gray Matter - drug effects</topic><topic>Gray Matter - pathology</topic><topic>Grey matter volume</topic><topic>Humans</topic><topic>Male</topic><topic>Neuropsychological Tests</topic><topic>Pregnancy</topic><topic>Prenatal Exposure Delayed Effects</topic><topic>Total intracranial volume</topic><topic>Voxel based morphometry</topic><topic>White Matter - drug effects</topic><topic>White Matter - pathology</topic><topic>White matter volume</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sreedharan, R.M.</creatorcontrib><creatorcontrib>Sheelakumari, R.</creatorcontrib><creatorcontrib>Anila, K.M.</creatorcontrib><creatorcontrib>Kesavadas, C.</creatorcontrib><creatorcontrib>Thomas, S.V.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuroradiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sreedharan, R.M.</au><au>Sheelakumari, R.</au><au>Anila, K.M.</au><au>Kesavadas, C.</au><au>Thomas, S.V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reduced brain volumes in children of women with epilepsy: A neuropsychological and voxel based morphometric analysis in pre-adolescent children</atitle><jtitle>Journal of neuroradiology</jtitle><addtitle>J Neuroradiol</addtitle><date>2018-10</date><risdate>2018</risdate><volume>45</volume><issue>6</issue><spage>380</spage><epage>385</epage><pages>380-385</pages><issn>0150-9861</issn><abstract>•Mean FSIQ was lower in children with antenatal AED exposure (CAED) compared to controls (P=0.001)•CAED had also significantly reduced TBV,GMV (P<0.001)•Mean CSF volume was significantly larger for the CAED group (P<0.001)
Children of Women with Epilepsy with antenatal exposure to antiepileptic drugs (CAED) have reduced neuropsychological functions. We aimed to explore the anatomical basis for this impairment by comparing the brain volumes of CAED with that of matched healthy children without antenatal AED exposure (COAED).
CAED aged 8–12 years were recruited from the Kerala Registry of epilepsy and pregnancy that prospectively follows up children of women with epilepsy and COAED from children attending the imaging department for minor illnesses. Maternal clinical details and the neuropsychological data including IQ of CAED and COAED were obtained. Total intracranial volume (TBV), grey matter volume (GMV), white matter volume (WMV) and volumes of deep grey matter were measured by Voxel Based Morphometry.
We studied 30 CAED (mean age 10.8+1.11 years) and 35 COAED (mean age 10.64+1.26). The antenatal AED exposure for the CAED was monotherapy for 8 children and polytherapy for 22 children. The CAED had significantly lower (P<0.001) IQ (77.5+13.8), TBV(1259.55±169.85mL) and GMV (672.51±85.42 mL) compared to the IQ (87.0+13.5), TBV(1405.37±161mL) and GMV (745.427±86.69 mL) of COAED. CAED had lower volumes for Lt Inferior Triangular Gyrus, and hippocampi on both sides, when compared to COAED. Group analysis CAED showed less GMV (P<0.05) for left inferior and middle frontal gyri relative to COAED.
These observations point towards an anatomical basis of lower GMV for the lower neuropsychological functions in children with antenatal AED exposure.</abstract><cop>France</cop><pub>Elsevier Masson SAS</pub><pmid>29505839</pmid><doi>10.1016/j.neurad.2018.02.005</doi><tpages>6</tpages></addata></record> |
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| subjects | Anticonvulsants - adverse effects Antiepileptic drugs Brain - drug effects Brain - pathology Child Children of woman with epilepsy Epilepsy - drug therapy Female Gray Matter - drug effects Gray Matter - pathology Grey matter volume Humans Male Neuropsychological Tests Pregnancy Prenatal Exposure Delayed Effects Total intracranial volume Voxel based morphometry White Matter - drug effects White Matter - pathology White matter volume |
| title | Reduced brain volumes in children of women with epilepsy: A neuropsychological and voxel based morphometric analysis in pre-adolescent children |
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