Night-time activation of the intrarenal renin-angiotensin system due to nocturnal hypertension is associated with renal arteriosclerosis in normotensive IgA nephropathy patients
Intrarenal renin-angiotensin system (RAS) activation plays an important role in the development of hypertension and renal damage. However, the association between daytime and night-time intrarenal RAS activation and renal structural damage in normotensive IgA nephropathy patients is unclear. We inve...
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| Veröffentlicht in: | Hypertension research 2018-05, Vol.41 (5), p.334-341 |
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| creator | Ohashi, Naro Isobe, Shinsuke Matsuyama, Takashi Ishigaki, Sayaka Tsuji, Naoko Fujikura, Tomoyuki Tsuji, Takayuki Kato, Akihiko Yasuda, Hideo |
| description | Intrarenal renin-angiotensin system (RAS) activation plays an important role in the development of hypertension and renal damage. However, the association between daytime and night-time intrarenal RAS activation and renal structural damage in normotensive IgA nephropathy patients is unclear. We investigated the relationships between urinary angiotensinogen (U-AGT) excretion, which reflects intrarenal RAS activity, and renal structural damage (i.e., endocapillary and mesangial cell hypercellularity, arteriolar hyalinosis and arteriosclerosis levels, and global glomerulosclerosis and tubulointerstitial fibrosis percentages) in 27 normotensive IgA nephropathy patients (age 39.2 ± 13.6 years, 10 men and 17 women, estimated glomerular filtration rate (eGFR) 74.0 ± 17.3 ml/min/1.73 m
, urinary protein excretion 0.58 ± 0.50 g/day, and U-AGT excretion 64.9 ± 100.6 μg/day). The arteriosclerosis level had a significant positive association with the daytime and night-time U-AGT excretion levels. By contrast, the endocapillary and mesangial cell hypercellularity and arteriolar hyalinosis levels and global glomerulosclerosis and tubulointerstitial fibrosis percentages did not correlate with the daytime and night-time U-AGT excretion levels. The daytime and night-time U-AGT excretion levels were higher in patients with arteriosclerotic changes than in patients without these changes. Multiple linear regression analysis revealed that the arteriosclerosis levels had a significant positive association with the U-AGT excretion levels at night after adjusting for age, sex, body mass index, and the eGFR. However, when diastolic BP was added as an independent variable, the relationship between U-AGT excretion and arteriosclerosis at night disappeared. In normotensive IgA nephropathy patients, intrarenal RAS activation at night due to nocturnal hypertension may be associated with arteriosclerosis. |
| doi_str_mv | 10.1038/s41440-018-0026-4 |
| format | Article |
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, urinary protein excretion 0.58 ± 0.50 g/day, and U-AGT excretion 64.9 ± 100.6 μg/day). The arteriosclerosis level had a significant positive association with the daytime and night-time U-AGT excretion levels. By contrast, the endocapillary and mesangial cell hypercellularity and arteriolar hyalinosis levels and global glomerulosclerosis and tubulointerstitial fibrosis percentages did not correlate with the daytime and night-time U-AGT excretion levels. The daytime and night-time U-AGT excretion levels were higher in patients with arteriosclerotic changes than in patients without these changes. Multiple linear regression analysis revealed that the arteriosclerosis levels had a significant positive association with the U-AGT excretion levels at night after adjusting for age, sex, body mass index, and the eGFR. However, when diastolic BP was added as an independent variable, the relationship between U-AGT excretion and arteriosclerosis at night disappeared. In normotensive IgA nephropathy patients, intrarenal RAS activation at night due to nocturnal hypertension may be associated with arteriosclerosis.</description><identifier>ISSN: 0916-9636</identifier><identifier>EISSN: 1348-4214</identifier><identifier>DOI: 10.1038/s41440-018-0026-4</identifier><identifier>PMID: 29507351</identifier><language>eng</language><publisher>England: Nature Publishing Group</publisher><subject>Adult ; Arteriosclerosis ; Arteriosclerosis - complications ; Arteriosclerosis - pathology ; Arteriosclerosis - physiopathology ; Blood Pressure ; Female ; Glomerular Filtration Rate ; Glomerulonephritis, IGA - pathology ; Glomerulonephritis, IGA - physiopathology ; Humans ; Hypertension ; Hypertension - complications ; Hypertension - pathology ; Hypertension - physiopathology ; Kidney Diseases - complications ; Kidney Diseases - pathology ; Kidney Diseases - physiopathology ; Male ; Middle Aged ; Renal Circulation ; Renin-Angiotensin System</subject><ispartof>Hypertension research, 2018-05, Vol.41 (5), p.334-341</ispartof><rights>Copyright Nature Publishing Group May 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c283t-750a0179439b5b12e7316c2acedf7902730ff336089b4150d3cf9ad0875f2f443</citedby><cites>FETCH-LOGICAL-c283t-750a0179439b5b12e7316c2acedf7902730ff336089b4150d3cf9ad0875f2f443</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29507351$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ohashi, Naro</creatorcontrib><creatorcontrib>Isobe, Shinsuke</creatorcontrib><creatorcontrib>Matsuyama, Takashi</creatorcontrib><creatorcontrib>Ishigaki, Sayaka</creatorcontrib><creatorcontrib>Tsuji, Naoko</creatorcontrib><creatorcontrib>Fujikura, Tomoyuki</creatorcontrib><creatorcontrib>Tsuji, Takayuki</creatorcontrib><creatorcontrib>Kato, Akihiko</creatorcontrib><creatorcontrib>Yasuda, Hideo</creatorcontrib><title>Night-time activation of the intrarenal renin-angiotensin system due to nocturnal hypertension is associated with renal arteriosclerosis in normotensive IgA nephropathy patients</title><title>Hypertension research</title><addtitle>Hypertens Res</addtitle><description>Intrarenal renin-angiotensin system (RAS) activation plays an important role in the development of hypertension and renal damage. However, the association between daytime and night-time intrarenal RAS activation and renal structural damage in normotensive IgA nephropathy patients is unclear. We investigated the relationships between urinary angiotensinogen (U-AGT) excretion, which reflects intrarenal RAS activity, and renal structural damage (i.e., endocapillary and mesangial cell hypercellularity, arteriolar hyalinosis and arteriosclerosis levels, and global glomerulosclerosis and tubulointerstitial fibrosis percentages) in 27 normotensive IgA nephropathy patients (age 39.2 ± 13.6 years, 10 men and 17 women, estimated glomerular filtration rate (eGFR) 74.0 ± 17.3 ml/min/1.73 m
, urinary protein excretion 0.58 ± 0.50 g/day, and U-AGT excretion 64.9 ± 100.6 μg/day). The arteriosclerosis level had a significant positive association with the daytime and night-time U-AGT excretion levels. By contrast, the endocapillary and mesangial cell hypercellularity and arteriolar hyalinosis levels and global glomerulosclerosis and tubulointerstitial fibrosis percentages did not correlate with the daytime and night-time U-AGT excretion levels. The daytime and night-time U-AGT excretion levels were higher in patients with arteriosclerotic changes than in patients without these changes. Multiple linear regression analysis revealed that the arteriosclerosis levels had a significant positive association with the U-AGT excretion levels at night after adjusting for age, sex, body mass index, and the eGFR. However, when diastolic BP was added as an independent variable, the relationship between U-AGT excretion and arteriosclerosis at night disappeared. In normotensive IgA nephropathy patients, intrarenal RAS activation at night due to nocturnal hypertension may be associated with arteriosclerosis.</description><subject>Adult</subject><subject>Arteriosclerosis</subject><subject>Arteriosclerosis - complications</subject><subject>Arteriosclerosis - pathology</subject><subject>Arteriosclerosis - physiopathology</subject><subject>Blood Pressure</subject><subject>Female</subject><subject>Glomerular Filtration Rate</subject><subject>Glomerulonephritis, IGA - pathology</subject><subject>Glomerulonephritis, IGA - physiopathology</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - complications</subject><subject>Hypertension - pathology</subject><subject>Hypertension - physiopathology</subject><subject>Kidney Diseases - complications</subject><subject>Kidney Diseases - pathology</subject><subject>Kidney Diseases - physiopathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Renal Circulation</subject><subject>Renin-Angiotensin System</subject><issn>0916-9636</issn><issn>1348-4214</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkctu1DAUQC0EokPhA9ggS2zYGPxKHC-rikelCjawjjzO9cRVYgfbKZrP4g9xmsKCzfXm-Ej3HoReM_qeUdF9yJJJSQllHaGUt0Q-QQcmZEckZ_IpOlDNWqJb0V6gFznfVaZrNHuOLrhuqBINO6DfX_1pLKT4GbCxxd-b4mPA0eEyAvahJJMgmAnX6QMx4eRjgZB9wPmcC8x4WAGXiEO0ZU0bOZ4XSA9MFfmMTc7RelNgwL98GfHuMxVJPmY7QYq5YtUYYpp3-z3gm9MVDrCMKS6mjGdcp4dQ8kv0zJkpw6vH9xL9-PTx-_UXcvvt88311S2xvBOFqIYaypSWQh-bI-OgBGstNxYGpzTlSlDnhGhpp4-SNXQQ1mkz0E41jjspxSV6t3uXFH-ukEs_-2xhmkyAuOaeU8a4oo3a0Lf_oXfx4RYbJRoupBKqUmynbF04J3D9kvxs0rlntN969nvPvvbst579Zn7zaF6PMwz_fvwNKP4A1I-fig</recordid><startdate>20180501</startdate><enddate>20180501</enddate><creator>Ohashi, Naro</creator><creator>Isobe, Shinsuke</creator><creator>Matsuyama, Takashi</creator><creator>Ishigaki, Sayaka</creator><creator>Tsuji, Naoko</creator><creator>Fujikura, Tomoyuki</creator><creator>Tsuji, Takayuki</creator><creator>Kato, Akihiko</creator><creator>Yasuda, Hideo</creator><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20180501</creationdate><title>Night-time activation of the intrarenal renin-angiotensin system due to nocturnal hypertension is associated with renal arteriosclerosis in normotensive IgA nephropathy patients</title><author>Ohashi, Naro ; Isobe, Shinsuke ; Matsuyama, Takashi ; Ishigaki, Sayaka ; Tsuji, Naoko ; Fujikura, Tomoyuki ; Tsuji, Takayuki ; Kato, Akihiko ; Yasuda, Hideo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c283t-750a0179439b5b12e7316c2acedf7902730ff336089b4150d3cf9ad0875f2f443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Arteriosclerosis</topic><topic>Arteriosclerosis - complications</topic><topic>Arteriosclerosis - pathology</topic><topic>Arteriosclerosis - physiopathology</topic><topic>Blood Pressure</topic><topic>Female</topic><topic>Glomerular Filtration Rate</topic><topic>Glomerulonephritis, IGA - pathology</topic><topic>Glomerulonephritis, IGA - physiopathology</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypertension - complications</topic><topic>Hypertension - pathology</topic><topic>Hypertension - physiopathology</topic><topic>Kidney Diseases - complications</topic><topic>Kidney Diseases - pathology</topic><topic>Kidney Diseases - physiopathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Renal Circulation</topic><topic>Renin-Angiotensin System</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ohashi, Naro</creatorcontrib><creatorcontrib>Isobe, Shinsuke</creatorcontrib><creatorcontrib>Matsuyama, Takashi</creatorcontrib><creatorcontrib>Ishigaki, Sayaka</creatorcontrib><creatorcontrib>Tsuji, Naoko</creatorcontrib><creatorcontrib>Fujikura, Tomoyuki</creatorcontrib><creatorcontrib>Tsuji, Takayuki</creatorcontrib><creatorcontrib>Kato, Akihiko</creatorcontrib><creatorcontrib>Yasuda, Hideo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Hypertension research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ohashi, Naro</au><au>Isobe, Shinsuke</au><au>Matsuyama, Takashi</au><au>Ishigaki, Sayaka</au><au>Tsuji, Naoko</au><au>Fujikura, Tomoyuki</au><au>Tsuji, Takayuki</au><au>Kato, Akihiko</au><au>Yasuda, Hideo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Night-time activation of the intrarenal renin-angiotensin system due to nocturnal hypertension is associated with renal arteriosclerosis in normotensive IgA nephropathy patients</atitle><jtitle>Hypertension research</jtitle><addtitle>Hypertens Res</addtitle><date>2018-05-01</date><risdate>2018</risdate><volume>41</volume><issue>5</issue><spage>334</spage><epage>341</epage><pages>334-341</pages><issn>0916-9636</issn><eissn>1348-4214</eissn><abstract>Intrarenal renin-angiotensin system (RAS) activation plays an important role in the development of hypertension and renal damage. However, the association between daytime and night-time intrarenal RAS activation and renal structural damage in normotensive IgA nephropathy patients is unclear. We investigated the relationships between urinary angiotensinogen (U-AGT) excretion, which reflects intrarenal RAS activity, and renal structural damage (i.e., endocapillary and mesangial cell hypercellularity, arteriolar hyalinosis and arteriosclerosis levels, and global glomerulosclerosis and tubulointerstitial fibrosis percentages) in 27 normotensive IgA nephropathy patients (age 39.2 ± 13.6 years, 10 men and 17 women, estimated glomerular filtration rate (eGFR) 74.0 ± 17.3 ml/min/1.73 m
, urinary protein excretion 0.58 ± 0.50 g/day, and U-AGT excretion 64.9 ± 100.6 μg/day). The arteriosclerosis level had a significant positive association with the daytime and night-time U-AGT excretion levels. By contrast, the endocapillary and mesangial cell hypercellularity and arteriolar hyalinosis levels and global glomerulosclerosis and tubulointerstitial fibrosis percentages did not correlate with the daytime and night-time U-AGT excretion levels. The daytime and night-time U-AGT excretion levels were higher in patients with arteriosclerotic changes than in patients without these changes. Multiple linear regression analysis revealed that the arteriosclerosis levels had a significant positive association with the U-AGT excretion levels at night after adjusting for age, sex, body mass index, and the eGFR. However, when diastolic BP was added as an independent variable, the relationship between U-AGT excretion and arteriosclerosis at night disappeared. In normotensive IgA nephropathy patients, intrarenal RAS activation at night due to nocturnal hypertension may be associated with arteriosclerosis.</abstract><cop>England</cop><pub>Nature Publishing Group</pub><pmid>29507351</pmid><doi>10.1038/s41440-018-0026-4</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Arteriosclerosis Arteriosclerosis - complications Arteriosclerosis - pathology Arteriosclerosis - physiopathology Blood Pressure Female Glomerular Filtration Rate Glomerulonephritis, IGA - pathology Glomerulonephritis, IGA - physiopathology Humans Hypertension Hypertension - complications Hypertension - pathology Hypertension - physiopathology Kidney Diseases - complications Kidney Diseases - pathology Kidney Diseases - physiopathology Male Middle Aged Renal Circulation Renin-Angiotensin System |
| title | Night-time activation of the intrarenal renin-angiotensin system due to nocturnal hypertension is associated with renal arteriosclerosis in normotensive IgA nephropathy patients |
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