Regulation of brain development and brain function by the transcriptional repressor RP58

•In the developing cortex, Rp58 (also known Znf238, Zfp238, Zbtb18), a sequence-specific transcriptional repressor, is expressed in glutamatergic projection neurons and progenitor cells. Rp58-deficient mice have a higher progenitor cell number. RP58 represses all four Id genes (Id1-Id4), which regul...

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Veröffentlicht in:	Brain research 2019-02, Vol.1705, p.15-23
1. Verfasser:	Okado, Haruo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Evolution Cell Cycle Cell cycle exit Cell Differentiation - genetics Cell Movement - genetics Cerebral cortex Cerebral Cortex - embryology Cerebral Cortex - metabolism Embryonic Development Gene Expression Regulation, Developmental - genetics Hippocampus - metabolism Mice Neocortex - metabolism Neurogenesis - physiology Neuroglia - metabolism Neurons - metabolism POK family Progenitor cell Repressor Proteins - genetics Repressor Proteins - metabolism Repressor Proteins - physiology RP58 Spatio-Temporal Analysis Stem Cells - physiology Transcription Factors - metabolism Transcriptional repressor
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