Studying the Phenotypic and Genotypic Expression of Antibiotic Resistance in Campylobacter jejuni under Stress Conditions
Specific features for the development of resistance in Campylobacter jejuni strains were studied after treatment with antibiotics of 6 pharmacological groups. Populations of 18 native strains of C. jejuni (isolated from raw poultry products) and their subcultures (obtained after 2-3-fold stress expo...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2018-03, Vol.164 (4), p.466-472 |
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| creator | Efimochkina, N. R. Stetsenko, V. V. Bykova, I. V. Markova, Yu. M. Polyanina, A. S. Aleshkina, A. I. Sheveleva, S. A. |
| description | Specific features for the development of resistance in
Campylobacter jejuni
strains were studied after treatment with antibiotics of 6 pharmacological groups. Populations of 18 native strains of
C. jejuni
(isolated from raw poultry products) and their subcultures (obtained after 2-3-fold stress exposures to antimicrobial agents in subinhibitory doses) were examined to evaluate the expression of phenotypic antibiotic resistance. Genotypic properties of strains were studied by the PCR with primers that detect the presence of genes for resistance to aminoglycosides (
aphA-1
,
aphA-3
, and
aphA-7
), tetracyclines (
tetO
), and quinolones (
GZgyrA
). The majority of test strains of
C. jejuni
exhibited a high resistance to nalidixic acid, ciprofloxacin, and tetracycline, which reached the maximum value after numerous passages. The expression of antibiotic resistance was greatest in the presence of nalidixic acid and tetracycline. Ciprofloxacin resistance of 33% strains, which were initially resistant to this antibiotic, was increased after 2-3-fold treatment. We revealed a high degree of correspondence between phenotypic and genotypic profiles of antibiotic resistance in food isolates of
Campylobacter
. One, two, or more genes of
aphA
were identified in 85% strains phenotypically resistant to aminoglycosides. The
tetO
gene was found nearly in all strains resistant to tetracycline. Studying the biofilm matrix in
C. jejuni
after culturing with antibiotics in subinhibitory doses showed that quinolones (particularly nalidixic acid) and tetracyclines potentiate the formation of biofilms and increase the tolerance of
Campylobacter
to stress exposures. The intensity of biofilm growth was shown to depend little on the effect of macrolides and aminoglycosides. Therefore, the presence of these agents in residual concentrations is associated with a lower risk for the development of antibiotic resistance in
C. jejuni
populations. |
| doi_str_mv | 10.1007/s10517-018-4014-0 |
| format | Article |
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Campylobacter jejuni
strains were studied after treatment with antibiotics of 6 pharmacological groups. Populations of 18 native strains of
C. jejuni
(isolated from raw poultry products) and their subcultures (obtained after 2-3-fold stress exposures to antimicrobial agents in subinhibitory doses) were examined to evaluate the expression of phenotypic antibiotic resistance. Genotypic properties of strains were studied by the PCR with primers that detect the presence of genes for resistance to aminoglycosides (
aphA-1
,
aphA-3
, and
aphA-7
), tetracyclines (
tetO
), and quinolones (
GZgyrA
). The majority of test strains of
C. jejuni
exhibited a high resistance to nalidixic acid, ciprofloxacin, and tetracycline, which reached the maximum value after numerous passages. The expression of antibiotic resistance was greatest in the presence of nalidixic acid and tetracycline. Ciprofloxacin resistance of 33% strains, which were initially resistant to this antibiotic, was increased after 2-3-fold treatment. We revealed a high degree of correspondence between phenotypic and genotypic profiles of antibiotic resistance in food isolates of
Campylobacter
. One, two, or more genes of
aphA
were identified in 85% strains phenotypically resistant to aminoglycosides. The
tetO
gene was found nearly in all strains resistant to tetracycline. Studying the biofilm matrix in
C. jejuni
after culturing with antibiotics in subinhibitory doses showed that quinolones (particularly nalidixic acid) and tetracyclines potentiate the formation of biofilms and increase the tolerance of
Campylobacter
to stress exposures. The intensity of biofilm growth was shown to depend little on the effect of macrolides and aminoglycosides. Therefore, the presence of these agents in residual concentrations is associated with a lower risk for the development of antibiotic resistance in
C. jejuni
populations.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-018-4014-0</identifier><identifier>PMID: 29504101</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Aminoglycosides ; Aminoglycosides - pharmacology ; Animals ; Anti-Bacterial Agents - pharmacology ; Antibiotic resistance ; Antibiotics ; Antimicrobial agents ; Biofilms ; Biofilms - drug effects ; Biofilms - growth & development ; Biomedical and Life Sciences ; Biomedicine ; Campylobacter ; Campylobacter Infections - microbiology ; Campylobacter jejuni ; Campylobacter jejuni - drug effects ; Campylobacter jejuni - genetics ; Campylobacter jejuni - growth & development ; Campylobacter jejuni - isolation & purification ; Cell Biology ; Chickens ; Ciprofloxacin ; Drug resistance ; Drug Resistance, Multiple, Bacterial ; Gene Expression Regulation, Bacterial ; Genes, Bacterial ; Genotype ; Internal Medicine ; Laboratory Medicine ; Meat Products - microbiology ; Microbial drug resistance ; Microbial Sensitivity Tests ; Nalidixic acid ; Pathogens ; Pathology ; Phenotype ; Primers ; Quinolones ; Quinolones - pharmacology ; Strains (organisms) ; Tetracyclines ; Tetracyclines - pharmacology</subject><ispartof>Bulletin of experimental biology and medicine, 2018-03, Vol.164 (4), p.466-472</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2018</rights><rights>COPYRIGHT 2018 Springer</rights><rights>Bulletin of Experimental Biology and Medicine is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-1144188cab8d8486fc4e2ad519042f1a6bd088f3f60f6602f46297c61999958f3</citedby><cites>FETCH-LOGICAL-c470t-1144188cab8d8486fc4e2ad519042f1a6bd088f3f60f6602f46297c61999958f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10517-018-4014-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10517-018-4014-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29504101$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Efimochkina, N. R.</creatorcontrib><creatorcontrib>Stetsenko, V. V.</creatorcontrib><creatorcontrib>Bykova, I. V.</creatorcontrib><creatorcontrib>Markova, Yu. M.</creatorcontrib><creatorcontrib>Polyanina, A. S.</creatorcontrib><creatorcontrib>Aleshkina, A. I.</creatorcontrib><creatorcontrib>Sheveleva, S. A.</creatorcontrib><title>Studying the Phenotypic and Genotypic Expression of Antibiotic Resistance in Campylobacter jejuni under Stress Conditions</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><addtitle>Bull Exp Biol Med</addtitle><description>Specific features for the development of resistance in
Campylobacter jejuni
strains were studied after treatment with antibiotics of 6 pharmacological groups. Populations of 18 native strains of
C. jejuni
(isolated from raw poultry products) and their subcultures (obtained after 2-3-fold stress exposures to antimicrobial agents in subinhibitory doses) were examined to evaluate the expression of phenotypic antibiotic resistance. Genotypic properties of strains were studied by the PCR with primers that detect the presence of genes for resistance to aminoglycosides (
aphA-1
,
aphA-3
, and
aphA-7
), tetracyclines (
tetO
), and quinolones (
GZgyrA
). The majority of test strains of
C. jejuni
exhibited a high resistance to nalidixic acid, ciprofloxacin, and tetracycline, which reached the maximum value after numerous passages. The expression of antibiotic resistance was greatest in the presence of nalidixic acid and tetracycline. Ciprofloxacin resistance of 33% strains, which were initially resistant to this antibiotic, was increased after 2-3-fold treatment. We revealed a high degree of correspondence between phenotypic and genotypic profiles of antibiotic resistance in food isolates of
Campylobacter
. One, two, or more genes of
aphA
were identified in 85% strains phenotypically resistant to aminoglycosides. The
tetO
gene was found nearly in all strains resistant to tetracycline. Studying the biofilm matrix in
C. jejuni
after culturing with antibiotics in subinhibitory doses showed that quinolones (particularly nalidixic acid) and tetracyclines potentiate the formation of biofilms and increase the tolerance of
Campylobacter
to stress exposures. The intensity of biofilm growth was shown to depend little on the effect of macrolides and aminoglycosides. Therefore, the presence of these agents in residual concentrations is associated with a lower risk for the development of antibiotic resistance in
C. jejuni
populations.</description><subject>Aminoglycosides</subject><subject>Aminoglycosides - pharmacology</subject><subject>Animals</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibiotic resistance</subject><subject>Antibiotics</subject><subject>Antimicrobial agents</subject><subject>Biofilms</subject><subject>Biofilms - drug effects</subject><subject>Biofilms - growth & development</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Campylobacter</subject><subject>Campylobacter Infections - microbiology</subject><subject>Campylobacter jejuni</subject><subject>Campylobacter jejuni - drug effects</subject><subject>Campylobacter jejuni - genetics</subject><subject>Campylobacter jejuni - growth & development</subject><subject>Campylobacter jejuni - isolation & purification</subject><subject>Cell Biology</subject><subject>Chickens</subject><subject>Ciprofloxacin</subject><subject>Drug resistance</subject><subject>Drug Resistance, Multiple, Bacterial</subject><subject>Gene Expression Regulation, Bacterial</subject><subject>Genes, Bacterial</subject><subject>Genotype</subject><subject>Internal Medicine</subject><subject>Laboratory Medicine</subject><subject>Meat Products - microbiology</subject><subject>Microbial drug resistance</subject><subject>Microbial Sensitivity Tests</subject><subject>Nalidixic acid</subject><subject>Pathogens</subject><subject>Pathology</subject><subject>Phenotype</subject><subject>Primers</subject><subject>Quinolones</subject><subject>Quinolones - pharmacology</subject><subject>Strains (organisms)</subject><subject>Tetracyclines</subject><subject>Tetracyclines - pharmacology</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kkFv1DAQhSMEotvCD-CCLCEhLikzjpN4j6tVaZEqgSicLcexd71K7BA7UvPvcbqlpQjsgzWe7z15rJdlbxDOEaD-GBBKrHNAnjNAlsOzbIVlXeScUnyerSBBOeOcn2SnIRyWEip8mZ3QdQkMAVfZfBOndrZuR-Jek6977XycB6uIdC25fKgubodRh2C9I96QjYu2sT6mxjcdbIjSKU2sI1vZD3PnG6miHslBHyZnyeTaVNzExYBsvWttTD7hVfbCyC7o1_fnWfbj08X37VV-_eXy83ZznStWQ8wRGUPOlWx4yxmvjGKayrbENTBqUFZNC5ybwlRgqgqoYRVd16rCdVplapxlH46-w-h_TjpE0dugdNdJp_0UBAUEzgBokdB3f6EHP40uve6OogxrpI_UTnZaWGd8HKVaTMWmLDhSKChL1Pk_qLRb3VvlnTY23T8RvP9DsNeyi_vgu-nus56CeATV6EMYtRHDaHs5zgJBLLkQx1yIlAux5EJA0ry9n2xqet0-KH4HIQH0CITUcjs9Po7-f9dfhwDASA</recordid><startdate>20180301</startdate><enddate>20180301</enddate><creator>Efimochkina, N. R.</creator><creator>Stetsenko, V. V.</creator><creator>Bykova, I. V.</creator><creator>Markova, Yu. M.</creator><creator>Polyanina, A. S.</creator><creator>Aleshkina, A. I.</creator><creator>Sheveleva, S. A.</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20180301</creationdate><title>Studying the Phenotypic and Genotypic Expression of Antibiotic Resistance in Campylobacter jejuni under Stress Conditions</title><author>Efimochkina, N. R. ; Stetsenko, V. V. ; Bykova, I. V. ; Markova, Yu. M. ; Polyanina, A. S. ; Aleshkina, A. I. ; Sheveleva, S. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-1144188cab8d8486fc4e2ad519042f1a6bd088f3f60f6602f46297c61999958f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aminoglycosides</topic><topic>Aminoglycosides - pharmacology</topic><topic>Animals</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibiotic resistance</topic><topic>Antibiotics</topic><topic>Antimicrobial agents</topic><topic>Biofilms</topic><topic>Biofilms - drug effects</topic><topic>Biofilms - growth & development</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Campylobacter</topic><topic>Campylobacter Infections - microbiology</topic><topic>Campylobacter jejuni</topic><topic>Campylobacter jejuni - drug effects</topic><topic>Campylobacter jejuni - genetics</topic><topic>Campylobacter jejuni - growth & development</topic><topic>Campylobacter jejuni - isolation & purification</topic><topic>Cell Biology</topic><topic>Chickens</topic><topic>Ciprofloxacin</topic><topic>Drug resistance</topic><topic>Drug Resistance, Multiple, Bacterial</topic><topic>Gene Expression Regulation, Bacterial</topic><topic>Genes, Bacterial</topic><topic>Genotype</topic><topic>Internal Medicine</topic><topic>Laboratory Medicine</topic><topic>Meat Products - microbiology</topic><topic>Microbial drug resistance</topic><topic>Microbial Sensitivity Tests</topic><topic>Nalidixic acid</topic><topic>Pathogens</topic><topic>Pathology</topic><topic>Phenotype</topic><topic>Primers</topic><topic>Quinolones</topic><topic>Quinolones - pharmacology</topic><topic>Strains (organisms)</topic><topic>Tetracyclines</topic><topic>Tetracyclines - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Efimochkina, N. 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A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Bulletin of experimental biology and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Efimochkina, N. R.</au><au>Stetsenko, V. V.</au><au>Bykova, I. V.</au><au>Markova, Yu. M.</au><au>Polyanina, A. S.</au><au>Aleshkina, A. I.</au><au>Sheveleva, S. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Studying the Phenotypic and Genotypic Expression of Antibiotic Resistance in Campylobacter jejuni under Stress Conditions</atitle><jtitle>Bulletin of experimental biology and medicine</jtitle><stitle>Bull Exp Biol Med</stitle><addtitle>Bull Exp Biol Med</addtitle><date>2018-03-01</date><risdate>2018</risdate><volume>164</volume><issue>4</issue><spage>466</spage><epage>472</epage><pages>466-472</pages><issn>0007-4888</issn><eissn>1573-8221</eissn><abstract>Specific features for the development of resistance in
Campylobacter jejuni
strains were studied after treatment with antibiotics of 6 pharmacological groups. Populations of 18 native strains of
C. jejuni
(isolated from raw poultry products) and their subcultures (obtained after 2-3-fold stress exposures to antimicrobial agents in subinhibitory doses) were examined to evaluate the expression of phenotypic antibiotic resistance. Genotypic properties of strains were studied by the PCR with primers that detect the presence of genes for resistance to aminoglycosides (
aphA-1
,
aphA-3
, and
aphA-7
), tetracyclines (
tetO
), and quinolones (
GZgyrA
). The majority of test strains of
C. jejuni
exhibited a high resistance to nalidixic acid, ciprofloxacin, and tetracycline, which reached the maximum value after numerous passages. The expression of antibiotic resistance was greatest in the presence of nalidixic acid and tetracycline. Ciprofloxacin resistance of 33% strains, which were initially resistant to this antibiotic, was increased after 2-3-fold treatment. We revealed a high degree of correspondence between phenotypic and genotypic profiles of antibiotic resistance in food isolates of
Campylobacter
. One, two, or more genes of
aphA
were identified in 85% strains phenotypically resistant to aminoglycosides. The
tetO
gene was found nearly in all strains resistant to tetracycline. Studying the biofilm matrix in
C. jejuni
after culturing with antibiotics in subinhibitory doses showed that quinolones (particularly nalidixic acid) and tetracyclines potentiate the formation of biofilms and increase the tolerance of
Campylobacter
to stress exposures. The intensity of biofilm growth was shown to depend little on the effect of macrolides and aminoglycosides. Therefore, the presence of these agents in residual concentrations is associated with a lower risk for the development of antibiotic resistance in
C. jejuni
populations.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>29504101</pmid><doi>10.1007/s10517-018-4014-0</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Bulletin of experimental biology and medicine, 2018-03, Vol.164 (4), p.466-472 |
| issn | 0007-4888 1573-8221 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2010840023 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Aminoglycosides Aminoglycosides - pharmacology Animals Anti-Bacterial Agents - pharmacology Antibiotic resistance Antibiotics Antimicrobial agents Biofilms Biofilms - drug effects Biofilms - growth & development Biomedical and Life Sciences Biomedicine Campylobacter Campylobacter Infections - microbiology Campylobacter jejuni Campylobacter jejuni - drug effects Campylobacter jejuni - genetics Campylobacter jejuni - growth & development Campylobacter jejuni - isolation & purification Cell Biology Chickens Ciprofloxacin Drug resistance Drug Resistance, Multiple, Bacterial Gene Expression Regulation, Bacterial Genes, Bacterial Genotype Internal Medicine Laboratory Medicine Meat Products - microbiology Microbial drug resistance Microbial Sensitivity Tests Nalidixic acid Pathogens Pathology Phenotype Primers Quinolones Quinolones - pharmacology Strains (organisms) Tetracyclines Tetracyclines - pharmacology |
| title | Studying the Phenotypic and Genotypic Expression of Antibiotic Resistance in Campylobacter jejuni under Stress Conditions |
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