Association between vitamin D levels and inflammatory activity in brain death: A prospective study
Vitamin D insufficiency is linked to several common inflammatory disorders. Brain death (BD) causes a massive catecholamine release, leading to intense inflammatory activity. We aimed to evaluate vitamin D serum levels in brain-dead individuals in comparison to critically ill patients without BD to...
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| Veröffentlicht in: | Transplant immunology 2018-06, Vol.48, p.65-69 |
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| container_title | Transplant immunology |
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| creator | Custódio, Geisiane Schwarz, Patrícia Crispim, Daisy Moraes, Rafael B. Czepielewski, Mauro Leitão, Cristiane B. Rech, Tatiana H. |
| description | Vitamin D insufficiency is linked to several common inflammatory disorders. Brain death (BD) causes a massive catecholamine release, leading to intense inflammatory activity. We aimed to evaluate vitamin D serum levels in brain-dead individuals in comparison to critically ill patients without BD to assess the correlation between vitamin D and cytokine levels.
Sixteen brain-dead patients and 32 critically ill controls were prospectively enrolled. Blood samples from 25 brain-dead patients from a previous study were also used for vitamin D quantification. Plasma TNF, IL-1β, IL-6, IL-8, IL-10, IFN-γ and serum vitamin D levels were compared using Student's t-test or one-way ANOVA. Spearman's test was used to assess the correlation between vitamin D and cytokine levels.
Mean vitamin D levels were 16.4 ± 7.9 ng/mL, with 52 patients (71.2%) classified as vitamin D deficient (serum levels |
| doi_str_mv | 10.1016/j.trim.2018.02.014 |
| format | Article |
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Sixteen brain-dead patients and 32 critically ill controls were prospectively enrolled. Blood samples from 25 brain-dead patients from a previous study were also used for vitamin D quantification. Plasma TNF, IL-1β, IL-6, IL-8, IL-10, IFN-γ and serum vitamin D levels were compared using Student's t-test or one-way ANOVA. Spearman's test was used to assess the correlation between vitamin D and cytokine levels.
Mean vitamin D levels were 16.4 ± 7.9 ng/mL, with 52 patients (71.2%) classified as vitamin D deficient (serum levels < 20 ng/mL). Vitamin D levels were similar in 41 brain-dead patients as compared to control subjects (15.6 ± 6.9 ng/mL vs 17.4 ± 9.0 ng/mL; p = 0.383). Moderate direct correlations were observed between vitamin D and IL-8, IL-10, and IFN-γ in the prospective group of 16 brain-dead patients (IL-8: r = 0.5, p = 0.049; IL-10 r = 0.67, p = 0.005; IFN-γ r = 0.6, p = 0.015). Vitamin D was inversely correlated with IL-6 (r = −0.36, p = 0.044) in critically ill controls.
Vitamin D serum levels were similarly low in brain-dead and critically ill patients. In brain-dead patients, vitamin D serum levels correlated with plasma IL-8, IL-10 and IFN-γ.
•Brain death causes an intense inflammatory activity.•Vitamin D might be associated with brain death-induced inflammation.•Vitamin D serum levels are similarly low in brain-dead and critically ill patients.•Vitamin D levels correlated with plasma IL-8, IL-10 and IFN in brain-dead patients.</description><identifier>ISSN: 0966-3274</identifier><identifier>EISSN: 1878-5492</identifier><identifier>DOI: 10.1016/j.trim.2018.02.014</identifier><identifier>PMID: 29501468</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Brain death ; Critical illness ; Cytokines ; Inflammation ; Vitamin D</subject><ispartof>Transplant immunology, 2018-06, Vol.48, p.65-69</ispartof><rights>2018 Elsevier B.V.</rights><rights>Copyright © 2018 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-f865b12cd89f614d150c4866fbb7493f5341c4e192d6cad811bf4c3dfa34d5ef3</citedby><cites>FETCH-LOGICAL-c356t-f865b12cd89f614d150c4866fbb7493f5341c4e192d6cad811bf4c3dfa34d5ef3</cites><orcidid>0000-0001-9582-2821</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0966327418300029$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29501468$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Custódio, Geisiane</creatorcontrib><creatorcontrib>Schwarz, Patrícia</creatorcontrib><creatorcontrib>Crispim, Daisy</creatorcontrib><creatorcontrib>Moraes, Rafael B.</creatorcontrib><creatorcontrib>Czepielewski, Mauro</creatorcontrib><creatorcontrib>Leitão, Cristiane B.</creatorcontrib><creatorcontrib>Rech, Tatiana H.</creatorcontrib><title>Association between vitamin D levels and inflammatory activity in brain death: A prospective study</title><title>Transplant immunology</title><addtitle>Transpl Immunol</addtitle><description>Vitamin D insufficiency is linked to several common inflammatory disorders. Brain death (BD) causes a massive catecholamine release, leading to intense inflammatory activity. We aimed to evaluate vitamin D serum levels in brain-dead individuals in comparison to critically ill patients without BD to assess the correlation between vitamin D and cytokine levels.
Sixteen brain-dead patients and 32 critically ill controls were prospectively enrolled. Blood samples from 25 brain-dead patients from a previous study were also used for vitamin D quantification. Plasma TNF, IL-1β, IL-6, IL-8, IL-10, IFN-γ and serum vitamin D levels were compared using Student's t-test or one-way ANOVA. Spearman's test was used to assess the correlation between vitamin D and cytokine levels.
Mean vitamin D levels were 16.4 ± 7.9 ng/mL, with 52 patients (71.2%) classified as vitamin D deficient (serum levels < 20 ng/mL). Vitamin D levels were similar in 41 brain-dead patients as compared to control subjects (15.6 ± 6.9 ng/mL vs 17.4 ± 9.0 ng/mL; p = 0.383). Moderate direct correlations were observed between vitamin D and IL-8, IL-10, and IFN-γ in the prospective group of 16 brain-dead patients (IL-8: r = 0.5, p = 0.049; IL-10 r = 0.67, p = 0.005; IFN-γ r = 0.6, p = 0.015). Vitamin D was inversely correlated with IL-6 (r = −0.36, p = 0.044) in critically ill controls.
Vitamin D serum levels were similarly low in brain-dead and critically ill patients. In brain-dead patients, vitamin D serum levels correlated with plasma IL-8, IL-10 and IFN-γ.
•Brain death causes an intense inflammatory activity.•Vitamin D might be associated with brain death-induced inflammation.•Vitamin D serum levels are similarly low in brain-dead and critically ill patients.•Vitamin D levels correlated with plasma IL-8, IL-10 and IFN in brain-dead patients.</description><subject>Brain death</subject><subject>Critical illness</subject><subject>Cytokines</subject><subject>Inflammation</subject><subject>Vitamin D</subject><issn>0966-3274</issn><issn>1878-5492</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kE1PAyEURYnRaK3-AReGpZsZgWEYxrhp6mfSxI2uCQOPSDMfdaA1_ffStLp080ge5968HISuKMkpoeJ2mcfRdzkjVOaE5YTyIzShspJZyWt2jCakFiIrWMXP0HkIS0IIK-vqFJ2xuky0kBPUzEIYjNfRDz1uIH4D9Hjjo-58jx9wCxtoA9a9xb53re46HYdxi7WJPlHbtMXNqNO0oOPnHZ7h1TiEFez-AYe4ttsLdOJ0G-Dy8E7Rx9Pj-_wlW7w9v85ni8wUpYiZk6JsKDNW1k5QbmlJDJdCuKapeF24suDUcKA1s8JoKyltHDeFdbrgtgRXTNHNvjdd8LWGEFXng4G21T0M66CSJyKLWlQyoWyPmnRsGMGpVTKpx62iRO3cqqXaud1lpCJMJVspdH3oXzcd2L_Ir8wE3O-BpAw2HkYVjIfegPVjEqLs4P_r_wGR9YxM</recordid><startdate>201806</startdate><enddate>201806</enddate><creator>Custódio, Geisiane</creator><creator>Schwarz, Patrícia</creator><creator>Crispim, Daisy</creator><creator>Moraes, Rafael B.</creator><creator>Czepielewski, Mauro</creator><creator>Leitão, Cristiane B.</creator><creator>Rech, Tatiana H.</creator><general>Elsevier B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9582-2821</orcidid></search><sort><creationdate>201806</creationdate><title>Association between vitamin D levels and inflammatory activity in brain death: A prospective study</title><author>Custódio, Geisiane ; Schwarz, Patrícia ; Crispim, Daisy ; Moraes, Rafael B. ; Czepielewski, Mauro ; Leitão, Cristiane B. ; Rech, Tatiana H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-f865b12cd89f614d150c4866fbb7493f5341c4e192d6cad811bf4c3dfa34d5ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Brain death</topic><topic>Critical illness</topic><topic>Cytokines</topic><topic>Inflammation</topic><topic>Vitamin D</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Custódio, Geisiane</creatorcontrib><creatorcontrib>Schwarz, Patrícia</creatorcontrib><creatorcontrib>Crispim, Daisy</creatorcontrib><creatorcontrib>Moraes, Rafael B.</creatorcontrib><creatorcontrib>Czepielewski, Mauro</creatorcontrib><creatorcontrib>Leitão, Cristiane B.</creatorcontrib><creatorcontrib>Rech, Tatiana H.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transplant immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Custódio, Geisiane</au><au>Schwarz, Patrícia</au><au>Crispim, Daisy</au><au>Moraes, Rafael B.</au><au>Czepielewski, Mauro</au><au>Leitão, Cristiane B.</au><au>Rech, Tatiana H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between vitamin D levels and inflammatory activity in brain death: A prospective study</atitle><jtitle>Transplant immunology</jtitle><addtitle>Transpl Immunol</addtitle><date>2018-06</date><risdate>2018</risdate><volume>48</volume><spage>65</spage><epage>69</epage><pages>65-69</pages><issn>0966-3274</issn><eissn>1878-5492</eissn><abstract>Vitamin D insufficiency is linked to several common inflammatory disorders. Brain death (BD) causes a massive catecholamine release, leading to intense inflammatory activity. We aimed to evaluate vitamin D serum levels in brain-dead individuals in comparison to critically ill patients without BD to assess the correlation between vitamin D and cytokine levels.
Sixteen brain-dead patients and 32 critically ill controls were prospectively enrolled. Blood samples from 25 brain-dead patients from a previous study were also used for vitamin D quantification. Plasma TNF, IL-1β, IL-6, IL-8, IL-10, IFN-γ and serum vitamin D levels were compared using Student's t-test or one-way ANOVA. Spearman's test was used to assess the correlation between vitamin D and cytokine levels.
Mean vitamin D levels were 16.4 ± 7.9 ng/mL, with 52 patients (71.2%) classified as vitamin D deficient (serum levels < 20 ng/mL). Vitamin D levels were similar in 41 brain-dead patients as compared to control subjects (15.6 ± 6.9 ng/mL vs 17.4 ± 9.0 ng/mL; p = 0.383). Moderate direct correlations were observed between vitamin D and IL-8, IL-10, and IFN-γ in the prospective group of 16 brain-dead patients (IL-8: r = 0.5, p = 0.049; IL-10 r = 0.67, p = 0.005; IFN-γ r = 0.6, p = 0.015). Vitamin D was inversely correlated with IL-6 (r = −0.36, p = 0.044) in critically ill controls.
Vitamin D serum levels were similarly low in brain-dead and critically ill patients. In brain-dead patients, vitamin D serum levels correlated with plasma IL-8, IL-10 and IFN-γ.
•Brain death causes an intense inflammatory activity.•Vitamin D might be associated with brain death-induced inflammation.•Vitamin D serum levels are similarly low in brain-dead and critically ill patients.•Vitamin D levels correlated with plasma IL-8, IL-10 and IFN in brain-dead patients.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>29501468</pmid><doi>10.1016/j.trim.2018.02.014</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0001-9582-2821</orcidid></addata></record> |
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| subjects | Brain death Critical illness Cytokines Inflammation Vitamin D |
| title | Association between vitamin D levels and inflammatory activity in brain death: A prospective study |
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