Are prostaglandins or calcium channel blockers efficient for free flap salvage? A review of the literature
The free flap failure rate is less than 5%. The responsible mechanisms of postoperative secondary ischemia are mostly vascular. The main postoperative complication leading to flap failure is thrombosis. Different strategies have been reported to improve the reliability of flaps and decrease the risk...
Gespeichert in:
| Veröffentlicht in: | Journal of stomatology, oral and maxillofacial surgery oral and maxillofacial surgery, 2018-09, Vol.119 (4), p.297-300 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 300 |
|---|---|
| container_issue | 4 |
| container_start_page | 297 |
| container_title | Journal of stomatology, oral and maxillofacial surgery |
| container_volume | 119 |
| creator | Huby, M. Rem, K. Moris, V. Guillier, D. Revol, M. Cristofari, S. |
| description | The free flap failure rate is less than 5%. The responsible mechanisms of postoperative secondary ischemia are mostly vascular. The main postoperative complication leading to flap failure is thrombosis. Different strategies have been reported to improve the reliability of flaps and decrease the risk of partial or total necrosis: thus, pharmacologic agents have been studied to reduce the risk of microvascular thrombosis. The aim of this review was to evaluate the effect of calcium channel blockers and prostaglandins on free skin flap survival. A systematic review of the literature was performed to identify articles studying the efficacy of calcium channel blockers and prostaglandins on free flap survival. After full text reading, eleven articles were finally included. Eight articles investigated the role of prostaglandins in free tissue transfers, two in rats subjects, one in rabbits, five in humans. Two articles studied the effect of calcium channel blockers on free flaps, one in rats subjects, one in rabbits. One article studied in different groups the effect of calcium channel blockers and prostaglandins on free flaps in rabbits. Literature regarding the efficacy of calcium channel blockers and prostaglandins to salvage free flap is poor and mainly based on animal models. Nevertheless, studies on prostaglandins showed a slight efficiency of these molecules for free flap salvage. Results are less reliable for calcium channel blockers and dependent on the molecule used. In conclusion, there is a lack of evidence to use them in clinical practice. |
| doi_str_mv | 10.1016/j.jormas.2018.02.014 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2010837451</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S2468785518300661</els_id><sourcerecordid>2010837451</sourcerecordid><originalsourceid>FETCH-LOGICAL-c362t-91284f7445ff24e0e2345da5ea17fbf4da481abf906176a1a012678b9b7aa19f3</originalsourceid><addsrcrecordid>eNp9kE1LxDAQhoMoKuo_EMnRy9Ykm_TjoiziFwhe9Bym6WRNTds1aRX_vVl2FU-eMoHnneF9CDnlLOOM5xdt1g6hg5gJxsuMiYxxuUMOhczLWVEqtftnPiAnMbaMJVLkuVT75EBUKv2YOiTtIiBdhSGOsPTQN66PdAjUgDdu6qh5hb5HT2s_mDcMkaK1zjjsR2oTZgMitR5WNIL_gCVe0QUN-OHwkw6Wjq9IvRsxwDgFPCZ7FnzEk-17RF5ub56v72ePT3cP14vHmZnnYpxVXJTSFlIqa4VEhmIuVQMKgRe2trIBWXKobcVyXuTAgXGRF2Vd1QUAr-z8iJxv9qZa7xPGUXcuGvSpHg5T1EkZK-eFVDyhcoOaZCAGtHoVXAfhS3Om16J1qzei16lSM6GT6BQ7216Y6g6b39CP1gRcbgBMPZONoONamsHGBTSjbgb3_4Vv0ZyRaQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2010837451</pqid></control><display><type>article</type><title>Are prostaglandins or calcium channel blockers efficient for free flap salvage? A review of the literature</title><source>Alma/SFX Local Collection</source><creator>Huby, M. ; Rem, K. ; Moris, V. ; Guillier, D. ; Revol, M. ; Cristofari, S.</creator><creatorcontrib>Huby, M. ; Rem, K. ; Moris, V. ; Guillier, D. ; Revol, M. ; Cristofari, S.</creatorcontrib><description>The free flap failure rate is less than 5%. The responsible mechanisms of postoperative secondary ischemia are mostly vascular. The main postoperative complication leading to flap failure is thrombosis. Different strategies have been reported to improve the reliability of flaps and decrease the risk of partial or total necrosis: thus, pharmacologic agents have been studied to reduce the risk of microvascular thrombosis. The aim of this review was to evaluate the effect of calcium channel blockers and prostaglandins on free skin flap survival. A systematic review of the literature was performed to identify articles studying the efficacy of calcium channel blockers and prostaglandins on free flap survival. After full text reading, eleven articles were finally included. Eight articles investigated the role of prostaglandins in free tissue transfers, two in rats subjects, one in rabbits, five in humans. Two articles studied the effect of calcium channel blockers on free flaps, one in rats subjects, one in rabbits. One article studied in different groups the effect of calcium channel blockers and prostaglandins on free flaps in rabbits. Literature regarding the efficacy of calcium channel blockers and prostaglandins to salvage free flap is poor and mainly based on animal models. Nevertheless, studies on prostaglandins showed a slight efficiency of these molecules for free flap salvage. Results are less reliable for calcium channel blockers and dependent on the molecule used. In conclusion, there is a lack of evidence to use them in clinical practice.</description><identifier>ISSN: 2468-7855</identifier><identifier>EISSN: 2468-7855</identifier><identifier>DOI: 10.1016/j.jormas.2018.02.014</identifier><identifier>PMID: 29501805</identifier><language>eng</language><publisher>France: Elsevier Masson SAS</publisher><subject>Calcium channel blocker ; Dentistry ; Free flap ; Prostaglandin</subject><ispartof>Journal of stomatology, oral and maxillofacial surgery, 2018-09, Vol.119 (4), p.297-300</ispartof><rights>2018 Elsevier Masson SAS</rights><rights>Copyright © 2018 Elsevier Masson SAS. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-91284f7445ff24e0e2345da5ea17fbf4da481abf906176a1a012678b9b7aa19f3</citedby><cites>FETCH-LOGICAL-c362t-91284f7445ff24e0e2345da5ea17fbf4da481abf906176a1a012678b9b7aa19f3</cites><orcidid>0000-0002-9131-0973</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29501805$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huby, M.</creatorcontrib><creatorcontrib>Rem, K.</creatorcontrib><creatorcontrib>Moris, V.</creatorcontrib><creatorcontrib>Guillier, D.</creatorcontrib><creatorcontrib>Revol, M.</creatorcontrib><creatorcontrib>Cristofari, S.</creatorcontrib><title>Are prostaglandins or calcium channel blockers efficient for free flap salvage? A review of the literature</title><title>Journal of stomatology, oral and maxillofacial surgery</title><addtitle>J Stomatol Oral Maxillofac Surg</addtitle><description>The free flap failure rate is less than 5%. The responsible mechanisms of postoperative secondary ischemia are mostly vascular. The main postoperative complication leading to flap failure is thrombosis. Different strategies have been reported to improve the reliability of flaps and decrease the risk of partial or total necrosis: thus, pharmacologic agents have been studied to reduce the risk of microvascular thrombosis. The aim of this review was to evaluate the effect of calcium channel blockers and prostaglandins on free skin flap survival. A systematic review of the literature was performed to identify articles studying the efficacy of calcium channel blockers and prostaglandins on free flap survival. After full text reading, eleven articles were finally included. Eight articles investigated the role of prostaglandins in free tissue transfers, two in rats subjects, one in rabbits, five in humans. Two articles studied the effect of calcium channel blockers on free flaps, one in rats subjects, one in rabbits. One article studied in different groups the effect of calcium channel blockers and prostaglandins on free flaps in rabbits. Literature regarding the efficacy of calcium channel blockers and prostaglandins to salvage free flap is poor and mainly based on animal models. Nevertheless, studies on prostaglandins showed a slight efficiency of these molecules for free flap salvage. Results are less reliable for calcium channel blockers and dependent on the molecule used. In conclusion, there is a lack of evidence to use them in clinical practice.</description><subject>Calcium channel blocker</subject><subject>Dentistry</subject><subject>Free flap</subject><subject>Prostaglandin</subject><issn>2468-7855</issn><issn>2468-7855</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LxDAQhoMoKuo_EMnRy9Ykm_TjoiziFwhe9Bym6WRNTds1aRX_vVl2FU-eMoHnneF9CDnlLOOM5xdt1g6hg5gJxsuMiYxxuUMOhczLWVEqtftnPiAnMbaMJVLkuVT75EBUKv2YOiTtIiBdhSGOsPTQN66PdAjUgDdu6qh5hb5HT2s_mDcMkaK1zjjsR2oTZgMitR5WNIL_gCVe0QUN-OHwkw6Wjq9IvRsxwDgFPCZ7FnzEk-17RF5ub56v72ePT3cP14vHmZnnYpxVXJTSFlIqa4VEhmIuVQMKgRe2trIBWXKobcVyXuTAgXGRF2Vd1QUAr-z8iJxv9qZa7xPGUXcuGvSpHg5T1EkZK-eFVDyhcoOaZCAGtHoVXAfhS3Om16J1qzei16lSM6GT6BQ7216Y6g6b39CP1gRcbgBMPZONoONamsHGBTSjbgb3_4Vv0ZyRaQ</recordid><startdate>20180901</startdate><enddate>20180901</enddate><creator>Huby, M.</creator><creator>Rem, K.</creator><creator>Moris, V.</creator><creator>Guillier, D.</creator><creator>Revol, M.</creator><creator>Cristofari, S.</creator><general>Elsevier Masson SAS</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9131-0973</orcidid></search><sort><creationdate>20180901</creationdate><title>Are prostaglandins or calcium channel blockers efficient for free flap salvage? A review of the literature</title><author>Huby, M. ; Rem, K. ; Moris, V. ; Guillier, D. ; Revol, M. ; Cristofari, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-91284f7445ff24e0e2345da5ea17fbf4da481abf906176a1a012678b9b7aa19f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Calcium channel blocker</topic><topic>Dentistry</topic><topic>Free flap</topic><topic>Prostaglandin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huby, M.</creatorcontrib><creatorcontrib>Rem, K.</creatorcontrib><creatorcontrib>Moris, V.</creatorcontrib><creatorcontrib>Guillier, D.</creatorcontrib><creatorcontrib>Revol, M.</creatorcontrib><creatorcontrib>Cristofari, S.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of stomatology, oral and maxillofacial surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huby, M.</au><au>Rem, K.</au><au>Moris, V.</au><au>Guillier, D.</au><au>Revol, M.</au><au>Cristofari, S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Are prostaglandins or calcium channel blockers efficient for free flap salvage? A review of the literature</atitle><jtitle>Journal of stomatology, oral and maxillofacial surgery</jtitle><addtitle>J Stomatol Oral Maxillofac Surg</addtitle><date>2018-09-01</date><risdate>2018</risdate><volume>119</volume><issue>4</issue><spage>297</spage><epage>300</epage><pages>297-300</pages><issn>2468-7855</issn><eissn>2468-7855</eissn><abstract>The free flap failure rate is less than 5%. The responsible mechanisms of postoperative secondary ischemia are mostly vascular. The main postoperative complication leading to flap failure is thrombosis. Different strategies have been reported to improve the reliability of flaps and decrease the risk of partial or total necrosis: thus, pharmacologic agents have been studied to reduce the risk of microvascular thrombosis. The aim of this review was to evaluate the effect of calcium channel blockers and prostaglandins on free skin flap survival. A systematic review of the literature was performed to identify articles studying the efficacy of calcium channel blockers and prostaglandins on free flap survival. After full text reading, eleven articles were finally included. Eight articles investigated the role of prostaglandins in free tissue transfers, two in rats subjects, one in rabbits, five in humans. Two articles studied the effect of calcium channel blockers on free flaps, one in rats subjects, one in rabbits. One article studied in different groups the effect of calcium channel blockers and prostaglandins on free flaps in rabbits. Literature regarding the efficacy of calcium channel blockers and prostaglandins to salvage free flap is poor and mainly based on animal models. Nevertheless, studies on prostaglandins showed a slight efficiency of these molecules for free flap salvage. Results are less reliable for calcium channel blockers and dependent on the molecule used. In conclusion, there is a lack of evidence to use them in clinical practice.</abstract><cop>France</cop><pub>Elsevier Masson SAS</pub><pmid>29501805</pmid><doi>10.1016/j.jormas.2018.02.014</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0002-9131-0973</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2468-7855 |
| ispartof | Journal of stomatology, oral and maxillofacial surgery, 2018-09, Vol.119 (4), p.297-300 |
| issn | 2468-7855 2468-7855 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2010837451 |
| source | Alma/SFX Local Collection |
| subjects | Calcium channel blocker Dentistry Free flap Prostaglandin |
| title | Are prostaglandins or calcium channel blockers efficient for free flap salvage? A review of the literature |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T20%3A49%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Are%20prostaglandins%20or%20calcium%20channel%20blockers%20efficient%20for%20free%20flap%20salvage?%20A%20review%20of%20the%20literature&rft.jtitle=Journal%20of%20stomatology,%20oral%20and%20maxillofacial%20surgery&rft.au=Huby,%20M.&rft.date=2018-09-01&rft.volume=119&rft.issue=4&rft.spage=297&rft.epage=300&rft.pages=297-300&rft.issn=2468-7855&rft.eissn=2468-7855&rft_id=info:doi/10.1016/j.jormas.2018.02.014&rft_dat=%3Cproquest_cross%3E2010837451%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2010837451&rft_id=info:pmid/29501805&rft_els_id=S2468785518300661&rfr_iscdi=true |