LncRNA PDIA3P interacts with c-Myc to regulate cell proliferation via induction of pentose phosphate pathway in multiple myeloma
Multiple myeloma (MM), the second most common hematologic malignancy, is an incurable disease characterized by the accumulation of malignant plasma cells within the bone marrow. Though great progresses have been made in understanding the mechanisms of MM, metabolic plasticity and drug resistance rem...
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| Veröffentlicht in: | Biochemical and biophysical research communications 2018-03, Vol.498 (1), p.207-213 |
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| creator | Yang, Xiangchou Ye, Haihao He, Muqing Zhou, Xiaohai Sun, Ni Guo, Wenjian Lin, Xiaoji Huang, He Lin, Ying Yao, Rongxin Wang, Hong |
| description | Multiple myeloma (MM), the second most common hematologic malignancy, is an incurable disease characterized by the accumulation of malignant plasma cells within the bone marrow. Though great progresses have been made in understanding the mechanisms of MM, metabolic plasticity and drug resistance remain largely unknown. In this study, we found lncRNA Protein disulfide isomerase family A member 3 pseudogene 1 (PDIA3P) is highly expressed in MM and is associated with the survival rate of MM patients. PDIA3P regulates MM growth and drug resistance through Glucose 6-phosphate dehydrogenase (G6PD) and the pentose phosphate pathway (PPP). Mechanistically, we revealed that PDIA3P interacts with c-Myc to enhance its transactivation activity and binding to G6PD promoter, stimulating G6PD expression and PPP flux. Our study identified PDIA3P as a novel c-Myc interacting lncRNA and elucidated crucial roles for PDIA3P in metabolic regulation of MM, providing a potential therapeutic target for MM patients.
•LncRNA PDIA3P is highly expressed in MM and reduces the survival rate of MM patients.•PDIA3P regulates MM cell growth and is associated with drug resistance.•PDIA3P promotes cell proliferation and drug resistance through G6PD and the pentose phosphate pathway.•PDIA3P interacts with c-Myc to stimulate the expression of G6PD. |
| doi_str_mv | 10.1016/j.bbrc.2018.02.211 |
| format | Article |
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•LncRNA PDIA3P is highly expressed in MM and reduces the survival rate of MM patients.•PDIA3P regulates MM cell growth and is associated with drug resistance.•PDIA3P promotes cell proliferation and drug resistance through G6PD and the pentose phosphate pathway.•PDIA3P interacts with c-Myc to stimulate the expression of G6PD.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/j.bbrc.2018.02.211</identifier><identifier>PMID: 29501744</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>c-Myc ; Cell Line, Tumor ; Cell Proliferation ; Drug resistance ; Drug Resistance, Neoplasm - genetics ; Female ; G6PD ; Gene Expression Regulation, Neoplastic ; Glucosephosphate Dehydrogenase - metabolism ; Humans ; Male ; Middle Aged ; Multiple myeloma ; Multiple Myeloma - genetics ; Multiple Myeloma - mortality ; Multiple Myeloma - pathology ; PDIA3P ; Pentose phosphate pathway ; Pentose Phosphate Pathway - genetics ; Proto-Oncogene Proteins c-myc - metabolism ; RNA, Long Noncoding - genetics ; RNA, Long Noncoding - metabolism ; Survival Rate</subject><ispartof>Biochemical and biophysical research communications, 2018-03, Vol.498 (1), p.207-213</ispartof><rights>2018 Elsevier Inc.</rights><rights>Copyright © 2018 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-ee813d1646a74123fce4a65430c642db5f1d1392a7f0f610d41dfffd3bd66a8c3</citedby><cites>FETCH-LOGICAL-c356t-ee813d1646a74123fce4a65430c642db5f1d1392a7f0f610d41dfffd3bd66a8c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bbrc.2018.02.211$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29501744$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Xiangchou</creatorcontrib><creatorcontrib>Ye, Haihao</creatorcontrib><creatorcontrib>He, Muqing</creatorcontrib><creatorcontrib>Zhou, Xiaohai</creatorcontrib><creatorcontrib>Sun, Ni</creatorcontrib><creatorcontrib>Guo, Wenjian</creatorcontrib><creatorcontrib>Lin, Xiaoji</creatorcontrib><creatorcontrib>Huang, He</creatorcontrib><creatorcontrib>Lin, Ying</creatorcontrib><creatorcontrib>Yao, Rongxin</creatorcontrib><creatorcontrib>Wang, Hong</creatorcontrib><title>LncRNA PDIA3P interacts with c-Myc to regulate cell proliferation via induction of pentose phosphate pathway in multiple myeloma</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>Multiple myeloma (MM), the second most common hematologic malignancy, is an incurable disease characterized by the accumulation of malignant plasma cells within the bone marrow. Though great progresses have been made in understanding the mechanisms of MM, metabolic plasticity and drug resistance remain largely unknown. In this study, we found lncRNA Protein disulfide isomerase family A member 3 pseudogene 1 (PDIA3P) is highly expressed in MM and is associated with the survival rate of MM patients. PDIA3P regulates MM growth and drug resistance through Glucose 6-phosphate dehydrogenase (G6PD) and the pentose phosphate pathway (PPP). Mechanistically, we revealed that PDIA3P interacts with c-Myc to enhance its transactivation activity and binding to G6PD promoter, stimulating G6PD expression and PPP flux. Our study identified PDIA3P as a novel c-Myc interacting lncRNA and elucidated crucial roles for PDIA3P in metabolic regulation of MM, providing a potential therapeutic target for MM patients.
•LncRNA PDIA3P is highly expressed in MM and reduces the survival rate of MM patients.•PDIA3P regulates MM cell growth and is associated with drug resistance.•PDIA3P promotes cell proliferation and drug resistance through G6PD and the pentose phosphate pathway.•PDIA3P interacts with c-Myc to stimulate the expression of G6PD.</description><subject>c-Myc</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation</subject><subject>Drug resistance</subject><subject>Drug Resistance, Neoplasm - genetics</subject><subject>Female</subject><subject>G6PD</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Glucosephosphate Dehydrogenase - metabolism</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multiple myeloma</subject><subject>Multiple Myeloma - genetics</subject><subject>Multiple Myeloma - mortality</subject><subject>Multiple Myeloma - pathology</subject><subject>PDIA3P</subject><subject>Pentose phosphate pathway</subject><subject>Pentose Phosphate Pathway - genetics</subject><subject>Proto-Oncogene Proteins c-myc - metabolism</subject><subject>RNA, Long Noncoding - genetics</subject><subject>RNA, Long Noncoding - metabolism</subject><subject>Survival Rate</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE2P0zAQhi0EYsvCH-CAfOSS4HFcN5G4VMvXSgVWCCRulmuPqaskDrazq9746Th04chpNNLzvJp5CXkOrAYG8tWx3u-jqTmDtma85gAPyApYxyoOTDwkK8aYrHgH3y_Ik5SOjAEI2T0mF7xbM9gIsSK_dqP58mlLb95cb5sb6seMUZuc6J3PB2qqjydDc6ARf8y9zkgN9j2dYui9K2D2YaS3XhfPzubPFhydcMwhIZ0OIU2HxZp0PtzpU8HoMPfZTz3S4YR9GPRT8sjpPuGz-3lJvr17-_XqQ7X7_P76arurTLOWuUJsobEghdQbAbxxBoWWa9EwIwW3-7UDC03H9cYxJ4FZAdY5Z5u9lVK3prkkL8-55fifM6asBp-Wb_SIYU6qtMjaZsMlFJSfURNDShGdmqIfdDwpYGppXh3V0vzitIpxVZov0ov7_Hk_oP2n_K26AK_PAJYvbz1GlYzH0aD1EU1WNvj_5f8GZUmWNQ</recordid><startdate>20180325</startdate><enddate>20180325</enddate><creator>Yang, Xiangchou</creator><creator>Ye, Haihao</creator><creator>He, Muqing</creator><creator>Zhou, Xiaohai</creator><creator>Sun, Ni</creator><creator>Guo, Wenjian</creator><creator>Lin, Xiaoji</creator><creator>Huang, He</creator><creator>Lin, Ying</creator><creator>Yao, Rongxin</creator><creator>Wang, Hong</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20180325</creationdate><title>LncRNA PDIA3P interacts with c-Myc to regulate cell proliferation via induction of pentose phosphate pathway in multiple myeloma</title><author>Yang, Xiangchou ; Ye, Haihao ; He, Muqing ; Zhou, Xiaohai ; Sun, Ni ; Guo, Wenjian ; Lin, Xiaoji ; Huang, He ; Lin, Ying ; Yao, Rongxin ; Wang, Hong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-ee813d1646a74123fce4a65430c642db5f1d1392a7f0f610d41dfffd3bd66a8c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>c-Myc</topic><topic>Cell Line, Tumor</topic><topic>Cell Proliferation</topic><topic>Drug resistance</topic><topic>Drug Resistance, Neoplasm - genetics</topic><topic>Female</topic><topic>G6PD</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Glucosephosphate Dehydrogenase - metabolism</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multiple myeloma</topic><topic>Multiple Myeloma - genetics</topic><topic>Multiple Myeloma - mortality</topic><topic>Multiple Myeloma - pathology</topic><topic>PDIA3P</topic><topic>Pentose phosphate pathway</topic><topic>Pentose Phosphate Pathway - genetics</topic><topic>Proto-Oncogene Proteins c-myc - metabolism</topic><topic>RNA, Long Noncoding - genetics</topic><topic>RNA, Long Noncoding - metabolism</topic><topic>Survival Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Xiangchou</creatorcontrib><creatorcontrib>Ye, Haihao</creatorcontrib><creatorcontrib>He, Muqing</creatorcontrib><creatorcontrib>Zhou, Xiaohai</creatorcontrib><creatorcontrib>Sun, Ni</creatorcontrib><creatorcontrib>Guo, Wenjian</creatorcontrib><creatorcontrib>Lin, Xiaoji</creatorcontrib><creatorcontrib>Huang, He</creatorcontrib><creatorcontrib>Lin, Ying</creatorcontrib><creatorcontrib>Yao, Rongxin</creatorcontrib><creatorcontrib>Wang, Hong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Xiangchou</au><au>Ye, Haihao</au><au>He, Muqing</au><au>Zhou, Xiaohai</au><au>Sun, Ni</au><au>Guo, Wenjian</au><au>Lin, Xiaoji</au><au>Huang, He</au><au>Lin, Ying</au><au>Yao, Rongxin</au><au>Wang, Hong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>LncRNA PDIA3P interacts with c-Myc to regulate cell proliferation via induction of pentose phosphate pathway in multiple myeloma</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>2018-03-25</date><risdate>2018</risdate><volume>498</volume><issue>1</issue><spage>207</spage><epage>213</epage><pages>207-213</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>Multiple myeloma (MM), the second most common hematologic malignancy, is an incurable disease characterized by the accumulation of malignant plasma cells within the bone marrow. Though great progresses have been made in understanding the mechanisms of MM, metabolic plasticity and drug resistance remain largely unknown. In this study, we found lncRNA Protein disulfide isomerase family A member 3 pseudogene 1 (PDIA3P) is highly expressed in MM and is associated with the survival rate of MM patients. PDIA3P regulates MM growth and drug resistance through Glucose 6-phosphate dehydrogenase (G6PD) and the pentose phosphate pathway (PPP). Mechanistically, we revealed that PDIA3P interacts with c-Myc to enhance its transactivation activity and binding to G6PD promoter, stimulating G6PD expression and PPP flux. Our study identified PDIA3P as a novel c-Myc interacting lncRNA and elucidated crucial roles for PDIA3P in metabolic regulation of MM, providing a potential therapeutic target for MM patients.
•LncRNA PDIA3P is highly expressed in MM and reduces the survival rate of MM patients.•PDIA3P regulates MM cell growth and is associated with drug resistance.•PDIA3P promotes cell proliferation and drug resistance through G6PD and the pentose phosphate pathway.•PDIA3P interacts with c-Myc to stimulate the expression of G6PD.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>29501744</pmid><doi>10.1016/j.bbrc.2018.02.211</doi><tpages>7</tpages></addata></record> |
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| subjects | c-Myc Cell Line, Tumor Cell Proliferation Drug resistance Drug Resistance, Neoplasm - genetics Female G6PD Gene Expression Regulation, Neoplastic Glucosephosphate Dehydrogenase - metabolism Humans Male Middle Aged Multiple myeloma Multiple Myeloma - genetics Multiple Myeloma - mortality Multiple Myeloma - pathology PDIA3P Pentose phosphate pathway Pentose Phosphate Pathway - genetics Proto-Oncogene Proteins c-myc - metabolism RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Survival Rate |
| title | LncRNA PDIA3P interacts with c-Myc to regulate cell proliferation via induction of pentose phosphate pathway in multiple myeloma |
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