Linoleic acid promotes mitochondrial biogenesis and maintains mitochondrial structure for prevention of streptozotocin damage in RIN-m5F cells

Linoleic acid (LA) improves insulin resistance and prevents diabetes. To investigate whether linoleic acid could protect against streptozotocin (STZ)-induced cell death, rat RIN-m5F cells were exposed to STZ. SL and SO groups consisted of cells treated with STZ and then LA or oleic acid (OA) respect...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2009-06, Vol.73 (6), p.1262-1267
Hauptverfasser:	Jeng, J.Y.(Cathay General Hospital, Taipei (Taiwan)), Yeh, T.S, Chiu, Y.H, Lee, Y.C, Cheng, H.H, Hsieh, R.H
Format:	Artikel
Sprache:	eng
Schlagworte:	ACIDE GRAS ACIDE LINOLENIQUE ACIDO LINILENICO ACIDOS GRASOS ADN Animals ARN MENSAJERO ARN MESSAGER Base Sequence Biological and medical sciences CELL CULTURE Cell Line CELLS CELLULE CELULAS CULTIVO DE CELULAS CULTURE DE CELLULE DAMAGE DANOS DEGAT DNA DNA Primers DNA, Mitochondrial - genetics FATTY ACIDS Fundamental and applied biological sciences. Psychology GLUCOSIDE GLUCOSIDES GLUCOSIDOS Islets of Langerhans - drug effects Islets of Langerhans - ultrastructure linoleic acid Linoleic Acid - pharmacology LINOLENIC ACID Membrane Potentials - drug effects MESSENGER RNA MITOCHONDRIA Mitochondria - drug effects Mitochondria - physiology mitochondrial biogenesis mitochondrial transcription factor MITOCHONDRIE MITOCONDRIA oleic acid PANCREAS Rats Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Streptozocin - toxicity streptozotocin
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