Structure optimization and preliminary bioactivity evaluation of N-hydroxybenzamide-based HDAC inhibitors with Y-shaped cap

[Display omitted] Histone deacetylase inhibitors (HDACIs) are effective small molecules in the treatment of human cancers. In our continuing efforts to develop novel N-hydroxyterephthalamide-based HDACIs, herein we report the design and development of a new class of N-hydroxybenzamide-based HDACIs....

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2018-05, Vol.26 (8), p.1859-1868
Hauptverfasser:	Yu, Chenggong, He, Feng, Qu, Ying, Zhang, Qiuqiong, Lv, Jiahui, Zhang, Xiangna, Xu, Ana, Miao, Pannan, Wu, Jingde
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiproliferative activity HDAC inhibitors Molecular docking Y-shaped cap
Online-Zugang:	Volltext
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