Stability of Cefazolin in Polyisoprene Elastomeric Infusion Devices
The aim was to investigate the stability of cefazolin in elastomeric infusion devices. Elastomeric devices (Infusor LV) that contain cefazolin (3 g/240 mL and 6 g/240 mL) were prepared and stored at 4°C for 72 hours and then at 35°C for 12 hours, followed by 25°C for 12 hours. An aliquot was withdra...
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| Veröffentlicht in: | Clinical therapeutics 2018-04, Vol.40 (4), p.664-667 |
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| container_title | Clinical therapeutics |
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| creator | Patel, Rahul P. Jacob, Jilson Sedeeq, Mohammed Ming, Long Chiau Wanandy, Troy Zaidi, Syed Tabish R. Peterson, Gregory M. |
| description | The aim was to investigate the stability of cefazolin in elastomeric infusion devices.
Elastomeric devices (Infusor LV) that contain cefazolin (3 g/240 mL and 6 g/240 mL) were prepared and stored at 4°C for 72 hours and then at 35°C for 12 hours, followed by 25°C for 12 hours. An aliquot was withdrawn at predefined time points and analyzed for the concentration of cefazolin. Samples were also assessed for changes in pH, solution color, and particle content.
Cefazolin retained acceptable chemical and physical stability over the studied storage period and conditions.
These findings will allow the administration of cefazolin by the Infusor LV elastomeric device in the outpatient and remote settings. |
| doi_str_mv | 10.1016/j.clinthera.2018.02.009 |
| format | Article |
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Elastomeric devices (Infusor LV) that contain cefazolin (3 g/240 mL and 6 g/240 mL) were prepared and stored at 4°C for 72 hours and then at 35°C for 12 hours, followed by 25°C for 12 hours. An aliquot was withdrawn at predefined time points and analyzed for the concentration of cefazolin. Samples were also assessed for changes in pH, solution color, and particle content.
Cefazolin retained acceptable chemical and physical stability over the studied storage period and conditions.
These findings will allow the administration of cefazolin by the Infusor LV elastomeric device in the outpatient and remote settings.</description><identifier>ISSN: 0149-2918</identifier><identifier>EISSN: 1879-114X</identifier><identifier>DOI: 10.1016/j.clinthera.2018.02.009</identifier><identifier>PMID: 29496321</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Antibiotics ; Cefazolin ; Chemical industry ; Chloride ; continuous infusion ; elastomeric device ; Elastomers ; high-performance liquid chromatography ; infective endocarditis ; Microscopy ; Shelf life ; Stability</subject><ispartof>Clinical therapeutics, 2018-04, Vol.40 (4), p.664-667</ispartof><rights>2018 Elsevier HS Journals, Inc.</rights><rights>Copyright © 2018 Elsevier HS Journals, Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Apr 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-523282fa323adf8f48cdd3df8dea0e5758f709c7fed7e22533438931959c61653</citedby><cites>FETCH-LOGICAL-c465t-523282fa323adf8f48cdd3df8dea0e5758f709c7fed7e22533438931959c61653</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0149291818300596$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29496321$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Patel, Rahul P.</creatorcontrib><creatorcontrib>Jacob, Jilson</creatorcontrib><creatorcontrib>Sedeeq, Mohammed</creatorcontrib><creatorcontrib>Ming, Long Chiau</creatorcontrib><creatorcontrib>Wanandy, Troy</creatorcontrib><creatorcontrib>Zaidi, Syed Tabish R.</creatorcontrib><creatorcontrib>Peterson, Gregory M.</creatorcontrib><title>Stability of Cefazolin in Polyisoprene Elastomeric Infusion Devices</title><title>Clinical therapeutics</title><addtitle>Clin Ther</addtitle><description>The aim was to investigate the stability of cefazolin in elastomeric infusion devices.
Elastomeric devices (Infusor LV) that contain cefazolin (3 g/240 mL and 6 g/240 mL) were prepared and stored at 4°C for 72 hours and then at 35°C for 12 hours, followed by 25°C for 12 hours. An aliquot was withdrawn at predefined time points and analyzed for the concentration of cefazolin. Samples were also assessed for changes in pH, solution color, and particle content.
Cefazolin retained acceptable chemical and physical stability over the studied storage period and conditions.
These findings will allow the administration of cefazolin by the Infusor LV elastomeric device in the outpatient and remote settings.</description><subject>Antibiotics</subject><subject>Cefazolin</subject><subject>Chemical industry</subject><subject>Chloride</subject><subject>continuous infusion</subject><subject>elastomeric device</subject><subject>Elastomers</subject><subject>high-performance liquid chromatography</subject><subject>infective endocarditis</subject><subject>Microscopy</subject><subject>Shelf life</subject><subject>Stability</subject><issn>0149-2918</issn><issn>1879-114X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkE1LAzEQhoMotlb_gi548bJrPvYjOZZatVBQUMFbSLMTTNluarJbqL_elFYPXoSBmcMz7wwPQlcEZwST8naZ6ca23Qd4lVFMeIZphrE4QkPCK5ESkr8foyEmuUipIHyAzkJYYoyZKOgpGlCRi5JRMkSTl04tbGO7beJMMgGjvlxMTmI9u2Zrg1t7aCGZNip0bgXe6mTWmj5Y1yZ3sLEawjk6MaoJcHHoI_R2P32dPKbzp4fZZDxPdV4WXVpQRjk1ilGmasNNznVdszjVoDAUVcFNhYWuDNQVUFowljMuGBGF0CUpCzZCN_vctXefPYROrmzQ0DSqBdcHGUVgVuVVjiN6_Qddut638btIUVZyTmIboWpPae9C8GDk2tuV8ltJsNx5lkv563kXzyWmMnqOm5eH_H6xgvp370dsBMZ7AKKQjQUvg7bQaqitB93J2tl_j3wDvXKR4Q</recordid><startdate>201804</startdate><enddate>201804</enddate><creator>Patel, Rahul P.</creator><creator>Jacob, Jilson</creator><creator>Sedeeq, Mohammed</creator><creator>Ming, Long Chiau</creator><creator>Wanandy, Troy</creator><creator>Zaidi, Syed Tabish R.</creator><creator>Peterson, Gregory M.</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>201804</creationdate><title>Stability of Cefazolin in Polyisoprene Elastomeric Infusion Devices</title><author>Patel, Rahul P. ; 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Elastomeric devices (Infusor LV) that contain cefazolin (3 g/240 mL and 6 g/240 mL) were prepared and stored at 4°C for 72 hours and then at 35°C for 12 hours, followed by 25°C for 12 hours. An aliquot was withdrawn at predefined time points and analyzed for the concentration of cefazolin. Samples were also assessed for changes in pH, solution color, and particle content.
Cefazolin retained acceptable chemical and physical stability over the studied storage period and conditions.
These findings will allow the administration of cefazolin by the Infusor LV elastomeric device in the outpatient and remote settings.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>29496321</pmid><doi>10.1016/j.clinthera.2018.02.009</doi><tpages>4</tpages></addata></record> |
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| source | Elsevier ScienceDirect Journals |
| subjects | Antibiotics Cefazolin Chemical industry Chloride continuous infusion elastomeric device Elastomers high-performance liquid chromatography infective endocarditis Microscopy Shelf life Stability |
| title | Stability of Cefazolin in Polyisoprene Elastomeric Infusion Devices |
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