Community-acquired Clostridium difficile infection in Serbian pediatric population
Carriage of Clostridium ( C. ) difficile in the intestinum of children, as well as its role in the disease (diarrhea) onset, is still controversial. The aim of this study is to investigate the community-acquired Clostridium difficile infection (CA-CDI) in Serbian pediatric population and to describe...
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| Veröffentlicht in: | European journal of clinical microbiology & infectious diseases 2018-06, Vol.37 (6), p.1061-1069 |
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| container_title | European journal of clinical microbiology & infectious diseases |
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| creator | Predrag, Stojanović Branislava, Kocić Nikola, Stojanović Niko, Radulovic Zorica, Stojanović-Radić Stanković-Đorđević, Dobrila |
| description | Carriage of
Clostridium
(
C.
)
difficile
in the intestinum of children, as well as its role in the disease (diarrhea) onset, is still controversial. The aim of this study is to investigate the community-acquired
Clostridium difficile
infection (CA-CDI) in Serbian pediatric population and to describe the basic clinical characteristics and risk factors for CA-CDI occurrence in Serbian pediatric population. The data obtained from 63 Serbian pediatric patients with CA-CDI and from control group of 126 children with community-acquired diarrhea, whose stool specimens were negative for
C. difficile
and toxins A/B, were mutually compared
.
In the current work, we found that children with CA-CDI display a significantly less severe disease clinical presentation than children with diarrheas of other origin. Lethal outcome was noted in two cases, but in children with severe underlying diseases (Crohn’s disease and leukemia). By using the multivariate statistical regression model, the following statistically significant risk factors for community-acquired
C. difficile
-associated diarrhea development were determined: previous application of laxatives (OR = 0.199, CI 0.55–0.79,
p
= 0.015), general antibiotic use during the previous 2 months (OR = 0.05, CI 0.02–0.17,
p
|
| doi_str_mv | 10.1007/s10096-018-3218-6 |
| format | Article |
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Clostridium
(
C.
)
difficile
in the intestinum of children, as well as its role in the disease (diarrhea) onset, is still controversial. The aim of this study is to investigate the community-acquired
Clostridium difficile
infection (CA-CDI) in Serbian pediatric population and to describe the basic clinical characteristics and risk factors for CA-CDI occurrence in Serbian pediatric population. The data obtained from 63 Serbian pediatric patients with CA-CDI and from control group of 126 children with community-acquired diarrhea, whose stool specimens were negative for
C. difficile
and toxins A/B, were mutually compared
.
In the current work, we found that children with CA-CDI display a significantly less severe disease clinical presentation than children with diarrheas of other origin. Lethal outcome was noted in two cases, but in children with severe underlying diseases (Crohn’s disease and leukemia). By using the multivariate statistical regression model, the following statistically significant risk factors for community-acquired
C. difficile
-associated diarrhea development were determined: previous application of laxatives (OR = 0.199, CI 0.55–0.79,
p
= 0.015), general antibiotic use during the previous 2 months (OR = 0.05, CI 0.02–0.17,
p
< 0.001), and specifically the use of penicillins (OR = 0.112, CI 0.04–0.31,
p
< 0.0001) and cephalosporins (OR = 0.16, CI 40.06–0.44,
p
< 0.0001). Antibiotics from the groups of cephalosporins and penicillins were found to be the most important independent risk factors. Laxative application plays a significant role in the community-acquired
Clostridium difficile
infections in children, with mechanisms that are not completely understood.</description><identifier>ISSN: 0934-9723</identifier><identifier>EISSN: 1435-4373</identifier><identifier>DOI: 10.1007/s10096-018-3218-6</identifier><identifier>PMID: 29497879</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Anti-Bacterial Agents - adverse effects ; Anti-Bacterial Agents - therapeutic use ; Antibiotics ; Bacteria ; Biomedical and Life Sciences ; Biomedicine ; Case-Control Studies ; Cephalosporins ; Cephalosporins - adverse effects ; Cephalosporins - therapeutic use ; Child ; Child, Preschool ; Children ; Clostridium difficile ; Clostridium difficile - drug effects ; Clostridium difficile - isolation & purification ; Clostridium Infections - drug therapy ; Clostridium Infections - epidemiology ; Clostridium Infections - microbiology ; Communities ; Community-Acquired Infections - drug therapy ; Community-Acquired Infections - epidemiology ; Community-Acquired Infections - microbiology ; Crohn's disease ; Cross Infection - drug therapy ; Cross Infection - epidemiology ; Cross Infection - microbiology ; Data processing ; Diarrhea ; Diarrhea - microbiology ; Disease ; Female ; Humans ; Infant ; Internal Medicine ; Laxatives ; Leukemia ; Male ; Mathematical models ; Medical Microbiology ; Original Article ; Pediatrics ; Penicillins - adverse effects ; Penicillins - therapeutic use ; Population (statistical) ; Prospective Studies ; Regression models ; Retrospective Studies ; Risk analysis ; Risk Factors ; Serbia - epidemiology ; Statistical analysis ; Statistical models ; Toxins</subject><ispartof>European journal of clinical microbiology & infectious diseases, 2018-06, Vol.37 (6), p.1061-1069</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2018</rights><rights>European Journal of Clinical Microbiology & Infectious Diseases is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-ff27914e4f01623f934f964ffa1db150981e31391df3d76c2cee128024b7df913</citedby><cites>FETCH-LOGICAL-c372t-ff27914e4f01623f934f964ffa1db150981e31391df3d76c2cee128024b7df913</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10096-018-3218-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10096-018-3218-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29497879$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Predrag, Stojanović</creatorcontrib><creatorcontrib>Branislava, Kocić</creatorcontrib><creatorcontrib>Nikola, Stojanović</creatorcontrib><creatorcontrib>Niko, Radulovic</creatorcontrib><creatorcontrib>Zorica, Stojanović-Radić</creatorcontrib><creatorcontrib>Stanković-Đorđević, Dobrila</creatorcontrib><title>Community-acquired Clostridium difficile infection in Serbian pediatric population</title><title>European journal of clinical microbiology & infectious diseases</title><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><description>Carriage of
Clostridium
(
C.
)
difficile
in the intestinum of children, as well as its role in the disease (diarrhea) onset, is still controversial. The aim of this study is to investigate the community-acquired
Clostridium difficile
infection (CA-CDI) in Serbian pediatric population and to describe the basic clinical characteristics and risk factors for CA-CDI occurrence in Serbian pediatric population. The data obtained from 63 Serbian pediatric patients with CA-CDI and from control group of 126 children with community-acquired diarrhea, whose stool specimens were negative for
C. difficile
and toxins A/B, were mutually compared
.
In the current work, we found that children with CA-CDI display a significantly less severe disease clinical presentation than children with diarrheas of other origin. Lethal outcome was noted in two cases, but in children with severe underlying diseases (Crohn’s disease and leukemia). By using the multivariate statistical regression model, the following statistically significant risk factors for community-acquired
C. difficile
-associated diarrhea development were determined: previous application of laxatives (OR = 0.199, CI 0.55–0.79,
p
= 0.015), general antibiotic use during the previous 2 months (OR = 0.05, CI 0.02–0.17,
p
< 0.001), and specifically the use of penicillins (OR = 0.112, CI 0.04–0.31,
p
< 0.0001) and cephalosporins (OR = 0.16, CI 40.06–0.44,
p
< 0.0001). Antibiotics from the groups of cephalosporins and penicillins were found to be the most important independent risk factors. Laxative application plays a significant role in the community-acquired
Clostridium difficile
infections in children, with mechanisms that are not completely understood.</description><subject>Anti-Bacterial Agents - adverse effects</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Antibiotics</subject><subject>Bacteria</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Case-Control Studies</subject><subject>Cephalosporins</subject><subject>Cephalosporins - adverse effects</subject><subject>Cephalosporins - therapeutic use</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Clostridium difficile</subject><subject>Clostridium difficile - drug effects</subject><subject>Clostridium difficile - isolation & purification</subject><subject>Clostridium Infections - drug therapy</subject><subject>Clostridium Infections - epidemiology</subject><subject>Clostridium Infections - microbiology</subject><subject>Communities</subject><subject>Community-Acquired Infections - drug therapy</subject><subject>Community-Acquired Infections - epidemiology</subject><subject>Community-Acquired Infections - microbiology</subject><subject>Crohn's disease</subject><subject>Cross Infection - drug therapy</subject><subject>Cross Infection - epidemiology</subject><subject>Cross Infection - microbiology</subject><subject>Data processing</subject><subject>Diarrhea</subject><subject>Diarrhea - microbiology</subject><subject>Disease</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>Internal Medicine</subject><subject>Laxatives</subject><subject>Leukemia</subject><subject>Male</subject><subject>Mathematical models</subject><subject>Medical Microbiology</subject><subject>Original Article</subject><subject>Pediatrics</subject><subject>Penicillins - adverse effects</subject><subject>Penicillins - therapeutic use</subject><subject>Population (statistical)</subject><subject>Prospective Studies</subject><subject>Regression models</subject><subject>Retrospective Studies</subject><subject>Risk analysis</subject><subject>Risk Factors</subject><subject>Serbia - epidemiology</subject><subject>Statistical analysis</subject><subject>Statistical models</subject><subject>Toxins</subject><issn>0934-9723</issn><issn>1435-4373</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kEtLxDAQx4Mo7rr6AbxIwYuXaiZJm-Yoiy9YEHycQ5uHZOlrk_bgtzelq4LgZTIwv_ln-CF0DvgaMOY3IVaRpxiKlJJY8gO0BEazlFFOD9ESC8pSwQldoJMQtjjuFJwfowURTMRWLNHLumuasXXDZ1qq3ei80cm67sLgnXZjk2hnrVOuNolrrVGD69rYJa_GV65sk95oV0ZWJX3Xj3U5zU_RkS3rYM727wq939-9rR_TzfPD0_p2kyrKyZBaS7gAZpjFkBNq461W5MzaEnQFGRYFGApUgLZU81wRZQyQAhNWcW0F0BW6mnN73-1GEwbZuKBMXZet6cYgCQYcPWSkiOjlH3Tbjb6N10UKCwaZgCkQZkr5LgRvrOy9a0r_KQHLSbichcsoXE7CZR53LvbJY9UY_bPxbTgCZAZCHLUfxv9-_X_qFxAuixE</recordid><startdate>20180601</startdate><enddate>20180601</enddate><creator>Predrag, Stojanović</creator><creator>Branislava, Kocić</creator><creator>Nikola, Stojanović</creator><creator>Niko, Radulovic</creator><creator>Zorica, Stojanović-Radić</creator><creator>Stanković-Đorđević, Dobrila</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20180601</creationdate><title>Community-acquired Clostridium difficile infection in Serbian pediatric population</title><author>Predrag, Stojanović ; Branislava, Kocić ; Nikola, Stojanović ; Niko, Radulovic ; Zorica, Stojanović-Radić ; Stanković-Đorđević, Dobrila</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-ff27914e4f01623f934f964ffa1db150981e31391df3d76c2cee128024b7df913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Anti-Bacterial Agents - adverse effects</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Antibiotics</topic><topic>Bacteria</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Case-Control Studies</topic><topic>Cephalosporins</topic><topic>Cephalosporins - adverse effects</topic><topic>Cephalosporins - therapeutic use</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Clostridium difficile</topic><topic>Clostridium difficile - drug effects</topic><topic>Clostridium difficile - isolation & purification</topic><topic>Clostridium Infections - drug therapy</topic><topic>Clostridium Infections - epidemiology</topic><topic>Clostridium Infections - microbiology</topic><topic>Communities</topic><topic>Community-Acquired Infections - drug therapy</topic><topic>Community-Acquired Infections - epidemiology</topic><topic>Community-Acquired Infections - microbiology</topic><topic>Crohn's disease</topic><topic>Cross Infection - drug therapy</topic><topic>Cross Infection - epidemiology</topic><topic>Cross Infection - microbiology</topic><topic>Data processing</topic><topic>Diarrhea</topic><topic>Diarrhea - microbiology</topic><topic>Disease</topic><topic>Female</topic><topic>Humans</topic><topic>Infant</topic><topic>Internal Medicine</topic><topic>Laxatives</topic><topic>Leukemia</topic><topic>Male</topic><topic>Mathematical models</topic><topic>Medical Microbiology</topic><topic>Original Article</topic><topic>Pediatrics</topic><topic>Penicillins - adverse effects</topic><topic>Penicillins - therapeutic use</topic><topic>Population (statistical)</topic><topic>Prospective Studies</topic><topic>Regression models</topic><topic>Retrospective Studies</topic><topic>Risk analysis</topic><topic>Risk Factors</topic><topic>Serbia - epidemiology</topic><topic>Statistical analysis</topic><topic>Statistical models</topic><topic>Toxins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Predrag, Stojanović</creatorcontrib><creatorcontrib>Branislava, Kocić</creatorcontrib><creatorcontrib>Nikola, Stojanović</creatorcontrib><creatorcontrib>Niko, Radulovic</creatorcontrib><creatorcontrib>Zorica, Stojanović-Radić</creatorcontrib><creatorcontrib>Stanković-Đorđević, Dobrila</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical microbiology & infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Predrag, Stojanović</au><au>Branislava, Kocić</au><au>Nikola, Stojanović</au><au>Niko, Radulovic</au><au>Zorica, Stojanović-Radić</au><au>Stanković-Đorđević, Dobrila</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Community-acquired Clostridium difficile infection in Serbian pediatric population</atitle><jtitle>European journal of clinical microbiology & infectious diseases</jtitle><stitle>Eur J Clin Microbiol Infect Dis</stitle><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><date>2018-06-01</date><risdate>2018</risdate><volume>37</volume><issue>6</issue><spage>1061</spage><epage>1069</epage><pages>1061-1069</pages><issn>0934-9723</issn><eissn>1435-4373</eissn><abstract>Carriage of
Clostridium
(
C.
)
difficile
in the intestinum of children, as well as its role in the disease (diarrhea) onset, is still controversial. The aim of this study is to investigate the community-acquired
Clostridium difficile
infection (CA-CDI) in Serbian pediatric population and to describe the basic clinical characteristics and risk factors for CA-CDI occurrence in Serbian pediatric population. The data obtained from 63 Serbian pediatric patients with CA-CDI and from control group of 126 children with community-acquired diarrhea, whose stool specimens were negative for
C. difficile
and toxins A/B, were mutually compared
.
In the current work, we found that children with CA-CDI display a significantly less severe disease clinical presentation than children with diarrheas of other origin. Lethal outcome was noted in two cases, but in children with severe underlying diseases (Crohn’s disease and leukemia). By using the multivariate statistical regression model, the following statistically significant risk factors for community-acquired
C. difficile
-associated diarrhea development were determined: previous application of laxatives (OR = 0.199, CI 0.55–0.79,
p
= 0.015), general antibiotic use during the previous 2 months (OR = 0.05, CI 0.02–0.17,
p
< 0.001), and specifically the use of penicillins (OR = 0.112, CI 0.04–0.31,
p
< 0.0001) and cephalosporins (OR = 0.16, CI 40.06–0.44,
p
< 0.0001). Antibiotics from the groups of cephalosporins and penicillins were found to be the most important independent risk factors. Laxative application plays a significant role in the community-acquired
Clostridium difficile
infections in children, with mechanisms that are not completely understood.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>29497879</pmid><doi>10.1007/s10096-018-3218-6</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0934-9723 |
| ispartof | European journal of clinical microbiology & infectious diseases, 2018-06, Vol.37 (6), p.1061-1069 |
| issn | 0934-9723 1435-4373 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2010373528 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Anti-Bacterial Agents - adverse effects Anti-Bacterial Agents - therapeutic use Antibiotics Bacteria Biomedical and Life Sciences Biomedicine Case-Control Studies Cephalosporins Cephalosporins - adverse effects Cephalosporins - therapeutic use Child Child, Preschool Children Clostridium difficile Clostridium difficile - drug effects Clostridium difficile - isolation & purification Clostridium Infections - drug therapy Clostridium Infections - epidemiology Clostridium Infections - microbiology Communities Community-Acquired Infections - drug therapy Community-Acquired Infections - epidemiology Community-Acquired Infections - microbiology Crohn's disease Cross Infection - drug therapy Cross Infection - epidemiology Cross Infection - microbiology Data processing Diarrhea Diarrhea - microbiology Disease Female Humans Infant Internal Medicine Laxatives Leukemia Male Mathematical models Medical Microbiology Original Article Pediatrics Penicillins - adverse effects Penicillins - therapeutic use Population (statistical) Prospective Studies Regression models Retrospective Studies Risk analysis Risk Factors Serbia - epidemiology Statistical analysis Statistical models Toxins |
| title | Community-acquired Clostridium difficile infection in Serbian pediatric population |
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