Evaluation of Total Flavonoids, Myricetin, and Quercetin from Hovenia dulcis Thunb. As Inhibitors of α-Amylase and α-Glucosidase
This study was designed to investigate the inhibition effect and mechanism of total flavonoids, myricetin and quercetin extracted from Hovenia dulcis Thunb. on α-amylase and α-glucosidase in order to explore the potential use of Hovenia flavonoids in alleviating postprandial hyperglycemia. The resul...
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| Veröffentlicht in: | Plant foods for human nutrition (Dordrecht) 2016-12, Vol.71 (4), p.444-449 |
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| creator | Meng, Yonghong Su, Anping Yuan, Shuang Zhao, Huaguo Tan, Siyuan Hu, Chingyuan Deng, Hong Guo, Yurong |
| description | This study was designed to investigate the inhibition effect and mechanism of total flavonoids, myricetin and quercetin extracted from
Hovenia dulcis
Thunb. on α-amylase and α-glucosidase in order to explore the potential use of
Hovenia
flavonoids in alleviating postprandial hyperglycemia. The results demonstrate that total flavonoids, myricetin, and quercetin were effective inhibitors of α-amylase with IC
50
values of 32.8, 662 and 770 μg ml
−1
, respectively. And all three were effective inhibitors of α-glucosidase with IC
50
values of 8, 3 and 32 μg ml
−1
, respectively. Enzyme kinetics tests and Lineweaver-Burk results showed the inhibition effects of total flavonoids, myricetin and quercrtin on α-amylase were all reversible and competitive, and the effects on α-glucosidase were all reversible but non-competitive. This study revealed that
Hovenia
flavonoids, especially myricetin, are effective and promising functional foods in alleviating type 2 diabetes mellitus. |
| doi_str_mv | 10.1007/s11130-016-0581-2 |
| format | Article |
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Hovenia dulcis
Thunb. on α-amylase and α-glucosidase in order to explore the potential use of
Hovenia
flavonoids in alleviating postprandial hyperglycemia. The results demonstrate that total flavonoids, myricetin, and quercetin were effective inhibitors of α-amylase with IC
50
values of 32.8, 662 and 770 μg ml
−1
, respectively. And all three were effective inhibitors of α-glucosidase with IC
50
values of 8, 3 and 32 μg ml
−1
, respectively. Enzyme kinetics tests and Lineweaver-Burk results showed the inhibition effects of total flavonoids, myricetin and quercrtin on α-amylase were all reversible and competitive, and the effects on α-glucosidase were all reversible but non-competitive. This study revealed that
Hovenia
flavonoids, especially myricetin, are effective and promising functional foods in alleviating type 2 diabetes mellitus.</description><identifier>ISSN: 0921-9668</identifier><identifier>EISSN: 1573-9104</identifier><identifier>DOI: 10.1007/s11130-016-0581-2</identifier><identifier>PMID: 27787697</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>alpha-amylase ; alpha-Amylases - antagonists & inhibitors ; alpha-Amylases - metabolism ; alpha-glucosidase ; alpha-Glucosidases - metabolism ; Amylases ; Chemistry ; Chemistry and Materials Science ; Chemistry/Food Science ; Diabetes ; Diabetes mellitus ; Ecology ; enzyme kinetics ; Flavonoids ; Flavonoids - analysis ; Flavonoids - pharmacology ; Food plants ; Food Science ; Functional Food ; functional foods ; Functional foods & nutraceuticals ; Glucosidase ; Glycoside Hydrolase Inhibitors - pharmacology ; Hovenia dulcis ; Hyperglycemia ; Hypoglycemic Agents - analysis ; Hypoglycemic Agents - pharmacology ; Inhibitors ; Inhibitory Concentration 50 ; myricetin ; Nutrition ; Original Paper ; Plant Extracts - analysis ; Plant Extracts - pharmacology ; Plant Physiology ; quercetin ; Quercetin - analysis ; Quercetin - pharmacology ; Rhamnaceae - chemistry</subject><ispartof>Plant foods for human nutrition (Dordrecht), 2016-12, Vol.71 (4), p.444-449</ispartof><rights>Springer Science+Business Media New York 2016</rights><rights>Copyright Springer Science & Business Media 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-8d33a4c7eb38f116ad2cb205727b67e1161563ec98ed3a9ab4daf67932ddf7213</citedby><cites>FETCH-LOGICAL-c405t-8d33a4c7eb38f116ad2cb205727b67e1161563ec98ed3a9ab4daf67932ddf7213</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11130-016-0581-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11130-016-0581-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27787697$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Meng, Yonghong</creatorcontrib><creatorcontrib>Su, Anping</creatorcontrib><creatorcontrib>Yuan, Shuang</creatorcontrib><creatorcontrib>Zhao, Huaguo</creatorcontrib><creatorcontrib>Tan, Siyuan</creatorcontrib><creatorcontrib>Hu, Chingyuan</creatorcontrib><creatorcontrib>Deng, Hong</creatorcontrib><creatorcontrib>Guo, Yurong</creatorcontrib><title>Evaluation of Total Flavonoids, Myricetin, and Quercetin from Hovenia dulcis Thunb. As Inhibitors of α-Amylase and α-Glucosidase</title><title>Plant foods for human nutrition (Dordrecht)</title><addtitle>Plant Foods Hum Nutr</addtitle><addtitle>Plant Foods Hum Nutr</addtitle><description>This study was designed to investigate the inhibition effect and mechanism of total flavonoids, myricetin and quercetin extracted from
Hovenia dulcis
Thunb. on α-amylase and α-glucosidase in order to explore the potential use of
Hovenia
flavonoids in alleviating postprandial hyperglycemia. The results demonstrate that total flavonoids, myricetin, and quercetin were effective inhibitors of α-amylase with IC
50
values of 32.8, 662 and 770 μg ml
−1
, respectively. And all three were effective inhibitors of α-glucosidase with IC
50
values of 8, 3 and 32 μg ml
−1
, respectively. Enzyme kinetics tests and Lineweaver-Burk results showed the inhibition effects of total flavonoids, myricetin and quercrtin on α-amylase were all reversible and competitive, and the effects on α-glucosidase were all reversible but non-competitive. This study revealed that
Hovenia
flavonoids, especially myricetin, are effective and promising functional foods in alleviating type 2 diabetes mellitus.</description><subject>alpha-amylase</subject><subject>alpha-Amylases - antagonists & inhibitors</subject><subject>alpha-Amylases - metabolism</subject><subject>alpha-glucosidase</subject><subject>alpha-Glucosidases - metabolism</subject><subject>Amylases</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chemistry/Food Science</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Ecology</subject><subject>enzyme kinetics</subject><subject>Flavonoids</subject><subject>Flavonoids - analysis</subject><subject>Flavonoids - pharmacology</subject><subject>Food plants</subject><subject>Food Science</subject><subject>Functional Food</subject><subject>functional foods</subject><subject>Functional foods & nutraceuticals</subject><subject>Glucosidase</subject><subject>Glycoside Hydrolase Inhibitors - pharmacology</subject><subject>Hovenia dulcis</subject><subject>Hyperglycemia</subject><subject>Hypoglycemic Agents - analysis</subject><subject>Hypoglycemic Agents - pharmacology</subject><subject>Inhibitors</subject><subject>Inhibitory Concentration 50</subject><subject>myricetin</subject><subject>Nutrition</subject><subject>Original Paper</subject><subject>Plant Extracts - analysis</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Physiology</subject><subject>quercetin</subject><subject>Quercetin - analysis</subject><subject>Quercetin - pharmacology</subject><subject>Rhamnaceae - chemistry</subject><issn>0921-9668</issn><issn>1573-9104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1qFTEYhoMo9li9ADcScOOiqfmZSTLLQ-kfVEQ4rkMmydiUTFKTyYGz7R15I16TOT1VRHAVvi_P-yTwAvCW4FOCsfhYCCEMI0w4wr0kiD4DK9ILhgaCu-dghQdK0MC5PAKvSrnDLcN5_xIcUSGk4INYgYfzrQ5VLz5FmCa4SYsO8CLobYrJ23ICP-2yN27x8QTqaOGX6vLjCKecZniVti56DW0Nxhe4ua1xPIXrAq_jrR_9knLZa3_-QOt5F3Rxj5I2XoZqUvG2rV6DF5MOxb15Oo_B14vzzdkVuvl8eX22vkGmw_2CpGVMd0a4kcmJEK4tNSPFvaBi5MK1Dek5c2aQzjI96LGzeuJiYNTaSVDCjsGHg_c-p-_VlUXNvhgXgo4u1aIoJphSTPnQ0Pf_oHep5th-p4iUWDJBuz1FDpTJqZTsJnWf_azzThGs9gWpQ0GqFaT2BSnaMu-ezHWcnf2T-N1IA-gBKO0qfnP5r6f_a_0Fzoechg</recordid><startdate>20161201</startdate><enddate>20161201</enddate><creator>Meng, Yonghong</creator><creator>Su, Anping</creator><creator>Yuan, Shuang</creator><creator>Zhao, Huaguo</creator><creator>Tan, Siyuan</creator><creator>Hu, Chingyuan</creator><creator>Deng, Hong</creator><creator>Guo, Yurong</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7S9</scope><scope>L.6</scope></search><sort><creationdate>20161201</creationdate><title>Evaluation of Total Flavonoids, Myricetin, and Quercetin from Hovenia dulcis Thunb. As Inhibitors of α-Amylase and α-Glucosidase</title><author>Meng, Yonghong ; Su, Anping ; Yuan, Shuang ; Zhao, Huaguo ; Tan, Siyuan ; Hu, Chingyuan ; Deng, Hong ; Guo, Yurong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-8d33a4c7eb38f116ad2cb205727b67e1161563ec98ed3a9ab4daf67932ddf7213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>alpha-amylase</topic><topic>alpha-Amylases - antagonists & inhibitors</topic><topic>alpha-Amylases - metabolism</topic><topic>alpha-glucosidase</topic><topic>alpha-Glucosidases - metabolism</topic><topic>Amylases</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chemistry/Food Science</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Ecology</topic><topic>enzyme kinetics</topic><topic>Flavonoids</topic><topic>Flavonoids - analysis</topic><topic>Flavonoids - pharmacology</topic><topic>Food plants</topic><topic>Food Science</topic><topic>Functional Food</topic><topic>functional foods</topic><topic>Functional foods & nutraceuticals</topic><topic>Glucosidase</topic><topic>Glycoside Hydrolase Inhibitors - pharmacology</topic><topic>Hovenia dulcis</topic><topic>Hyperglycemia</topic><topic>Hypoglycemic Agents - analysis</topic><topic>Hypoglycemic Agents - pharmacology</topic><topic>Inhibitors</topic><topic>Inhibitory Concentration 50</topic><topic>myricetin</topic><topic>Nutrition</topic><topic>Original Paper</topic><topic>Plant Extracts - analysis</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Physiology</topic><topic>quercetin</topic><topic>Quercetin - analysis</topic><topic>Quercetin - pharmacology</topic><topic>Rhamnaceae - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Meng, Yonghong</creatorcontrib><creatorcontrib>Su, Anping</creatorcontrib><creatorcontrib>Yuan, Shuang</creatorcontrib><creatorcontrib>Zhao, Huaguo</creatorcontrib><creatorcontrib>Tan, Siyuan</creatorcontrib><creatorcontrib>Hu, Chingyuan</creatorcontrib><creatorcontrib>Deng, Hong</creatorcontrib><creatorcontrib>Guo, Yurong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Plant foods for human nutrition (Dordrecht)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Meng, Yonghong</au><au>Su, Anping</au><au>Yuan, Shuang</au><au>Zhao, Huaguo</au><au>Tan, Siyuan</au><au>Hu, Chingyuan</au><au>Deng, Hong</au><au>Guo, Yurong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of Total Flavonoids, Myricetin, and Quercetin from Hovenia dulcis Thunb. As Inhibitors of α-Amylase and α-Glucosidase</atitle><jtitle>Plant foods for human nutrition (Dordrecht)</jtitle><stitle>Plant Foods Hum Nutr</stitle><addtitle>Plant Foods Hum Nutr</addtitle><date>2016-12-01</date><risdate>2016</risdate><volume>71</volume><issue>4</issue><spage>444</spage><epage>449</epage><pages>444-449</pages><issn>0921-9668</issn><eissn>1573-9104</eissn><abstract>This study was designed to investigate the inhibition effect and mechanism of total flavonoids, myricetin and quercetin extracted from
Hovenia dulcis
Thunb. on α-amylase and α-glucosidase in order to explore the potential use of
Hovenia
flavonoids in alleviating postprandial hyperglycemia. The results demonstrate that total flavonoids, myricetin, and quercetin were effective inhibitors of α-amylase with IC
50
values of 32.8, 662 and 770 μg ml
−1
, respectively. And all three were effective inhibitors of α-glucosidase with IC
50
values of 8, 3 and 32 μg ml
−1
, respectively. Enzyme kinetics tests and Lineweaver-Burk results showed the inhibition effects of total flavonoids, myricetin and quercrtin on α-amylase were all reversible and competitive, and the effects on α-glucosidase were all reversible but non-competitive. This study revealed that
Hovenia
flavonoids, especially myricetin, are effective and promising functional foods in alleviating type 2 diabetes mellitus.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>27787697</pmid><doi>10.1007/s11130-016-0581-2</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0921-9668 |
| ispartof | Plant foods for human nutrition (Dordrecht), 2016-12, Vol.71 (4), p.444-449 |
| issn | 0921-9668 1573-9104 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2010220269 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | alpha-amylase alpha-Amylases - antagonists & inhibitors alpha-Amylases - metabolism alpha-glucosidase alpha-Glucosidases - metabolism Amylases Chemistry Chemistry and Materials Science Chemistry/Food Science Diabetes Diabetes mellitus Ecology enzyme kinetics Flavonoids Flavonoids - analysis Flavonoids - pharmacology Food plants Food Science Functional Food functional foods Functional foods & nutraceuticals Glucosidase Glycoside Hydrolase Inhibitors - pharmacology Hovenia dulcis Hyperglycemia Hypoglycemic Agents - analysis Hypoglycemic Agents - pharmacology Inhibitors Inhibitory Concentration 50 myricetin Nutrition Original Paper Plant Extracts - analysis Plant Extracts - pharmacology Plant Physiology quercetin Quercetin - analysis Quercetin - pharmacology Rhamnaceae - chemistry |
| title | Evaluation of Total Flavonoids, Myricetin, and Quercetin from Hovenia dulcis Thunb. As Inhibitors of α-Amylase and α-Glucosidase |
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