Evidence for New beta 1-3 Galactosyltransferase Activity Involved in Biosynthesis of Unusual N-Glycan Harboring T-Antigen in Apis mellifera
In a previous study (Y. Kimura et al., Biosci. Biotechnol. Biochem., 70, 2583-2587, 2006), we found that new complex type N-glycans harboring Thomsen- Friedenreich antigen (Gal beta 1-3GalNAc) unit occur on royal jelly glycoproteins, suggesting the involvement of a new beta 1-3galactosyltransferase...
Gespeichert in:
| Veröffentlicht in: | Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2007-04, Vol.71 (4), p.1111-1114 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1114 |
|---|---|
| container_issue | 4 |
| container_start_page | 1111 |
| container_title | Bioscience, biotechnology, and biochemistry |
| container_volume | 71 |
| creator | Kimura, Yoshinobu Sakamura, Sho Ushijima, Takayuki Hama, Yoichiro Kajiura, Hiroyuki Fujiyama, Kazuhito Okihara, Kiyoshi Hashimoto, Ken Sugimoto, Hiroyuki Yamada, Hideo |
| description | In a previous study (Y. Kimura et al., Biosci. Biotechnol. Biochem., 70, 2583-2587, 2006), we found that new complex type N-glycans harboring Thomsen- Friedenreich antigen (Gal beta 1-3GalNAc) unit occur on royal jelly glycoproteins, suggesting the involvement of a new beta 1-3galactosyltransferase in the synthesis of the unusual complex type N-glycans. So far, such beta 1-3galactosyltransferase activity, which can transfer galactosyl residues with the beta 1-3 linkage to beta 1-4 GalNAc residues in N-glycan, has not been found among any eucaryotic cells. But using GalNAc sub(2)GlcNAc sub(2)Man sub(3)GlcNAc sub(2)-PA as acceptor N-glycan, we detected the beta 1-3 galactosyltransferase activity in membrane fraction prepared from honeybee cephalic portions. This result indicates that honeybee expresses a unique beta 1-3 galactosyltransferase involved in biosynthesis of the unusual N- glycan containing a tumor related antigen in the hypopharyngeal gland. |
| doi_str_mv | 10.1271/bbb.70081 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_miscellaneous_20099733</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>20099733</sourcerecordid><originalsourceid>FETCH-LOGICAL-n160t-cc5d172f74e60da441ed44eae63d77c105794940bec7f5e1b1d9610e485fa2453</originalsourceid><addsrcrecordid>eNotkEFPwjAcxRujiYge_AY9eSv2v3UrO06CQELwAmfSdf9hTWlx7Wb4DH5pRvT0kpf3fnl5hDwDn0Ai4bWqqonkfAo3ZASpkCwvhLwlI15AzqYig3vyEMIX54ORwYj8zntTo9NIG9_SDf7QCqOiwFK6UFbp6MPZxla50GCrAtJSR9ObeKYr13vbY02No29miLn4icEE6hu6c13olKUbtrBnrRxdqrbyrXEHumWli-aA7torT0P-iNaaK_2R3DXKBnz61zHZvc-3syVbfyxWs3LNHOQ8Mq2zGmTSSIE5r5UQgLUQqDBPayk18EwWohC8Qi2bDKGCusiBo5hmjUpElo7Jyx_31PrvDkPcH03Qwwrl0HdhnwznFDJN0wsOK2ad</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>20099733</pqid></control><display><type>article</type><title>Evidence for New beta 1-3 Galactosyltransferase Activity Involved in Biosynthesis of Unusual N-Glycan Harboring T-Antigen in Apis mellifera</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese</source><source>Open Access Titles of Japan</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Free Full-Text Journals in Chemistry</source><creator>Kimura, Yoshinobu ; Sakamura, Sho ; Ushijima, Takayuki ; Hama, Yoichiro ; Kajiura, Hiroyuki ; Fujiyama, Kazuhito ; Okihara, Kiyoshi ; Hashimoto, Ken ; Sugimoto, Hiroyuki ; Yamada, Hideo</creator><creatorcontrib>Kimura, Yoshinobu ; Sakamura, Sho ; Ushijima, Takayuki ; Hama, Yoichiro ; Kajiura, Hiroyuki ; Fujiyama, Kazuhito ; Okihara, Kiyoshi ; Hashimoto, Ken ; Sugimoto, Hiroyuki ; Yamada, Hideo</creatorcontrib><description>In a previous study (Y. Kimura et al., Biosci. Biotechnol. Biochem., 70, 2583-2587, 2006), we found that new complex type N-glycans harboring Thomsen- Friedenreich antigen (Gal beta 1-3GalNAc) unit occur on royal jelly glycoproteins, suggesting the involvement of a new beta 1-3galactosyltransferase in the synthesis of the unusual complex type N-glycans. So far, such beta 1-3galactosyltransferase activity, which can transfer galactosyl residues with the beta 1-3 linkage to beta 1-4 GalNAc residues in N-glycan, has not been found among any eucaryotic cells. But using GalNAc sub(2)GlcNAc sub(2)Man sub(3)GlcNAc sub(2)-PA as acceptor N-glycan, we detected the beta 1-3 galactosyltransferase activity in membrane fraction prepared from honeybee cephalic portions. This result indicates that honeybee expresses a unique beta 1-3 galactosyltransferase involved in biosynthesis of the unusual N- glycan containing a tumor related antigen in the hypopharyngeal gland.</description><identifier>ISSN: 0916-8451</identifier><identifier>EISSN: 1347-6947</identifier><identifier>DOI: 10.1271/bbb.70081</identifier><language>eng</language><subject>Apis mellifera</subject><ispartof>Bioscience, biotechnology, and biochemistry, 2007-04, Vol.71 (4), p.1111-1114</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids></links><search><creatorcontrib>Kimura, Yoshinobu</creatorcontrib><creatorcontrib>Sakamura, Sho</creatorcontrib><creatorcontrib>Ushijima, Takayuki</creatorcontrib><creatorcontrib>Hama, Yoichiro</creatorcontrib><creatorcontrib>Kajiura, Hiroyuki</creatorcontrib><creatorcontrib>Fujiyama, Kazuhito</creatorcontrib><creatorcontrib>Okihara, Kiyoshi</creatorcontrib><creatorcontrib>Hashimoto, Ken</creatorcontrib><creatorcontrib>Sugimoto, Hiroyuki</creatorcontrib><creatorcontrib>Yamada, Hideo</creatorcontrib><title>Evidence for New beta 1-3 Galactosyltransferase Activity Involved in Biosynthesis of Unusual N-Glycan Harboring T-Antigen in Apis mellifera</title><title>Bioscience, biotechnology, and biochemistry</title><description>In a previous study (Y. Kimura et al., Biosci. Biotechnol. Biochem., 70, 2583-2587, 2006), we found that new complex type N-glycans harboring Thomsen- Friedenreich antigen (Gal beta 1-3GalNAc) unit occur on royal jelly glycoproteins, suggesting the involvement of a new beta 1-3galactosyltransferase in the synthesis of the unusual complex type N-glycans. So far, such beta 1-3galactosyltransferase activity, which can transfer galactosyl residues with the beta 1-3 linkage to beta 1-4 GalNAc residues in N-glycan, has not been found among any eucaryotic cells. But using GalNAc sub(2)GlcNAc sub(2)Man sub(3)GlcNAc sub(2)-PA as acceptor N-glycan, we detected the beta 1-3 galactosyltransferase activity in membrane fraction prepared from honeybee cephalic portions. This result indicates that honeybee expresses a unique beta 1-3 galactosyltransferase involved in biosynthesis of the unusual N- glycan containing a tumor related antigen in the hypopharyngeal gland.</description><subject>Apis mellifera</subject><issn>0916-8451</issn><issn>1347-6947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNotkEFPwjAcxRujiYge_AY9eSv2v3UrO06CQELwAmfSdf9hTWlx7Wb4DH5pRvT0kpf3fnl5hDwDn0Ai4bWqqonkfAo3ZASpkCwvhLwlI15AzqYig3vyEMIX54ORwYj8zntTo9NIG9_SDf7QCqOiwFK6UFbp6MPZxla50GCrAtJSR9ObeKYr13vbY02No29miLn4icEE6hu6c13olKUbtrBnrRxdqrbyrXEHumWli-aA7torT0P-iNaaK_2R3DXKBnz61zHZvc-3syVbfyxWs3LNHOQ8Mq2zGmTSSIE5r5UQgLUQqDBPayk18EwWohC8Qi2bDKGCusiBo5hmjUpElo7Jyx_31PrvDkPcH03Qwwrl0HdhnwznFDJN0wsOK2ad</recordid><startdate>20070401</startdate><enddate>20070401</enddate><creator>Kimura, Yoshinobu</creator><creator>Sakamura, Sho</creator><creator>Ushijima, Takayuki</creator><creator>Hama, Yoichiro</creator><creator>Kajiura, Hiroyuki</creator><creator>Fujiyama, Kazuhito</creator><creator>Okihara, Kiyoshi</creator><creator>Hashimoto, Ken</creator><creator>Sugimoto, Hiroyuki</creator><creator>Yamada, Hideo</creator><scope>7QO</scope><scope>7SS</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20070401</creationdate><title>Evidence for New beta 1-3 Galactosyltransferase Activity Involved in Biosynthesis of Unusual N-Glycan Harboring T-Antigen in Apis mellifera</title><author>Kimura, Yoshinobu ; Sakamura, Sho ; Ushijima, Takayuki ; Hama, Yoichiro ; Kajiura, Hiroyuki ; Fujiyama, Kazuhito ; Okihara, Kiyoshi ; Hashimoto, Ken ; Sugimoto, Hiroyuki ; Yamada, Hideo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-n160t-cc5d172f74e60da441ed44eae63d77c105794940bec7f5e1b1d9610e485fa2453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Apis mellifera</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kimura, Yoshinobu</creatorcontrib><creatorcontrib>Sakamura, Sho</creatorcontrib><creatorcontrib>Ushijima, Takayuki</creatorcontrib><creatorcontrib>Hama, Yoichiro</creatorcontrib><creatorcontrib>Kajiura, Hiroyuki</creatorcontrib><creatorcontrib>Fujiyama, Kazuhito</creatorcontrib><creatorcontrib>Okihara, Kiyoshi</creatorcontrib><creatorcontrib>Hashimoto, Ken</creatorcontrib><creatorcontrib>Sugimoto, Hiroyuki</creatorcontrib><creatorcontrib>Yamada, Hideo</creatorcontrib><collection>Biotechnology Research Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Bioscience, biotechnology, and biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kimura, Yoshinobu</au><au>Sakamura, Sho</au><au>Ushijima, Takayuki</au><au>Hama, Yoichiro</au><au>Kajiura, Hiroyuki</au><au>Fujiyama, Kazuhito</au><au>Okihara, Kiyoshi</au><au>Hashimoto, Ken</au><au>Sugimoto, Hiroyuki</au><au>Yamada, Hideo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evidence for New beta 1-3 Galactosyltransferase Activity Involved in Biosynthesis of Unusual N-Glycan Harboring T-Antigen in Apis mellifera</atitle><jtitle>Bioscience, biotechnology, and biochemistry</jtitle><date>2007-04-01</date><risdate>2007</risdate><volume>71</volume><issue>4</issue><spage>1111</spage><epage>1114</epage><pages>1111-1114</pages><issn>0916-8451</issn><eissn>1347-6947</eissn><abstract>In a previous study (Y. Kimura et al., Biosci. Biotechnol. Biochem., 70, 2583-2587, 2006), we found that new complex type N-glycans harboring Thomsen- Friedenreich antigen (Gal beta 1-3GalNAc) unit occur on royal jelly glycoproteins, suggesting the involvement of a new beta 1-3galactosyltransferase in the synthesis of the unusual complex type N-glycans. So far, such beta 1-3galactosyltransferase activity, which can transfer galactosyl residues with the beta 1-3 linkage to beta 1-4 GalNAc residues in N-glycan, has not been found among any eucaryotic cells. But using GalNAc sub(2)GlcNAc sub(2)Man sub(3)GlcNAc sub(2)-PA as acceptor N-glycan, we detected the beta 1-3 galactosyltransferase activity in membrane fraction prepared from honeybee cephalic portions. This result indicates that honeybee expresses a unique beta 1-3 galactosyltransferase involved in biosynthesis of the unusual N- glycan containing a tumor related antigen in the hypopharyngeal gland.</abstract><doi>10.1271/bbb.70081</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0916-8451 |
| ispartof | Bioscience, biotechnology, and biochemistry, 2007-04, Vol.71 (4), p.1111-1114 |
| issn | 0916-8451 1347-6947 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_20099733 |
| source | Oxford University Press Journals All Titles (1996-Current); J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Open Access Titles of Japan; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Apis mellifera |
| title | Evidence for New beta 1-3 Galactosyltransferase Activity Involved in Biosynthesis of Unusual N-Glycan Harboring T-Antigen in Apis mellifera |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T12%3A19%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Evidence%20for%20New%20beta%201-3%20Galactosyltransferase%20Activity%20Involved%20in%20Biosynthesis%20of%20Unusual%20N-Glycan%20Harboring%20T-Antigen%20in%20Apis%20mellifera&rft.jtitle=Bioscience,%20biotechnology,%20and%20biochemistry&rft.au=Kimura,%20Yoshinobu&rft.date=2007-04-01&rft.volume=71&rft.issue=4&rft.spage=1111&rft.epage=1114&rft.pages=1111-1114&rft.issn=0916-8451&rft.eissn=1347-6947&rft_id=info:doi/10.1271/bbb.70081&rft_dat=%3Cproquest%3E20099733%3C/proquest%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=20099733&rft_id=info:pmid/&rfr_iscdi=true |