Chemically modified tetracycline (CMT)-3 inhibits histamine release and cytokine production in mast cells: possible involvement of protein kinase C

To find novel inhibitors of mast cell function we have studied the effect of a potent, non-antimicrobial, chemically modified tetracycline, CMT-3 or COL-3, on key functions of mast cells. In the presence of 25 microM CMT-3, the 48/80-induced histamine release from rat serosal mast cells was inhibite...

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Veröffentlicht in:	Inflammation research 2005-07, Vol.54 (7), p.304-312
Hauptverfasser:	Sandler, C, Ekokoski, E, Lindstedt, K A, Vainio, P J, Finel, M, Sorsa, T, Kovanen, P T, Golub, L M, Eklund, K K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD34 - biosynthesis Brain - metabolism Carcinogens Cell Line, Tumor Cells, Cultured Cloning, Molecular Cytokines - biosynthesis Cytokines - metabolism Dose-Response Relationship, Drug Fetal Blood Histamine - metabolism Histamine Release Humans Inflammation Interleukin-8 - metabolism Male Mast Cells - cytology Mast Cells - metabolism Phorbol 12,13-Dibutyrate - pharmacology Protein Kinase C - metabolism Protein Kinase C - physiology Protein Kinase C-alpha Protein Kinase C-delta Rats Rats, Wistar Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Tetracyclines - pharmacology Time Factors Tumor Necrosis Factor-alpha - metabolism
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