Safety evaluation of pigment containing Aspergillus carbonarius biomass in albino rats
Aspergillus carbonarius, an ascomycetes fungus, is known to produce pectinase in solid-state fermentation. A mutant strain of A. carbonarius UV-10046 selected for temperature tolerance over produced polygalacturonase and during growth accumulated an yellow pigment in its biomass. Since the colored f...
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| Veröffentlicht in: | Food and chemical toxicology 2007-03, Vol.45 (3), p.431-439 |
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| creator | Sanjay, K.R. Kumaresan, N. Akhilender Naidu, K. Viswanatha, S. Narasimhamurthy, K. Umesh Kumar, S. Vijayalakshmi, G. |
| description | Aspergillus carbonarius, an ascomycetes fungus, is known to produce pectinase in solid-state fermentation. A mutant strain of
A. carbonarius UV-10046 selected for temperature tolerance over produced polygalacturonase and during growth accumulated an yellow pigment in its biomass. Since the colored fungus suggested its application for food use, the freeze-dried biomass was evaluated to assess its safety in experimental animals. Acute and sub-acute toxicity studies were conducted on both sexes of albino rats. Feeding acute doses of
A. carbonarius freeze-dried biomass at 0.5–5.0
g/kg body weight to adult rats did not show any symptoms of toxicity or mortality of the rats. Similarly, dietary feeding of
A. carbonarius at 0.25–2.0% level (w/w) for 14 weeks did not produce any significant changes in food intake or gain in body weight of the experimental rats compared to control rats. There were no significant differences in the relative weight of vital organs, hematological parameters, macroscopic and microscopic changes in vital organs and serum enzyme levels between the experimental and control groups. The results clearly showed that acute and sub-acute oral feeding of freeze-dried whole cells of
A. carbonarius mutant for 14 weeks did not produce any toxic effects in male and female rats. |
| doi_str_mv | 10.1016/j.fct.2006.09.004 |
| format | Article |
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A. carbonarius UV-10046 selected for temperature tolerance over produced polygalacturonase and during growth accumulated an yellow pigment in its biomass. Since the colored fungus suggested its application for food use, the freeze-dried biomass was evaluated to assess its safety in experimental animals. Acute and sub-acute toxicity studies were conducted on both sexes of albino rats. Feeding acute doses of
A. carbonarius freeze-dried biomass at 0.5–5.0
g/kg body weight to adult rats did not show any symptoms of toxicity or mortality of the rats. Similarly, dietary feeding of
A. carbonarius at 0.25–2.0% level (w/w) for 14 weeks did not produce any significant changes in food intake or gain in body weight of the experimental rats compared to control rats. There were no significant differences in the relative weight of vital organs, hematological parameters, macroscopic and microscopic changes in vital organs and serum enzyme levels between the experimental and control groups. The results clearly showed that acute and sub-acute oral feeding of freeze-dried whole cells of
A. carbonarius mutant for 14 weeks did not produce any toxic effects in male and female rats.</description><identifier>ISSN: 0278-6915</identifier><identifier>EISSN: 1873-6351</identifier><identifier>DOI: 10.1016/j.fct.2006.09.004</identifier><identifier>PMID: 17084008</identifier><identifier>CODEN: FCTOD7</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>acute toxicity ; Administration, Oral ; Animal Feed ; animal models ; Animals ; Ascomycetes ; Ascomycota ; Aspergillus - chemistry ; Aspergillus - genetics ; Aspergillus carbonarius ; Biological and medical sciences ; Biomass ; Consumer Product Safety ; Eating - drug effects ; Female ; Food colorant ; food coloring ; heat tolerance ; Male ; Medical sciences ; Mutagenicity Tests ; mutants ; Organ Size - drug effects ; Pigment ; pigments ; Pigments, Biological - administration & dosage ; Pigments, Biological - toxicity ; polygalacturonase ; proximate composition ; Rats ; Rats, Wistar ; safety testing ; solid state fermentation ; subacute toxicity ; toxicity testing ; Toxicity Tests ; Toxicology</subject><ispartof>Food and chemical toxicology, 2007-03, Vol.45 (3), p.431-439</ispartof><rights>2006 Elsevier Ltd</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c467t-83198048c461c8152fcda9eb0f34158719c38ce6c9070d823f88faa128a2adea3</citedby><cites>FETCH-LOGICAL-c467t-83198048c461c8152fcda9eb0f34158719c38ce6c9070d823f88faa128a2adea3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.fct.2006.09.004$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18522223$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17084008$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sanjay, K.R.</creatorcontrib><creatorcontrib>Kumaresan, N.</creatorcontrib><creatorcontrib>Akhilender Naidu, K.</creatorcontrib><creatorcontrib>Viswanatha, S.</creatorcontrib><creatorcontrib>Narasimhamurthy, K.</creatorcontrib><creatorcontrib>Umesh Kumar, S.</creatorcontrib><creatorcontrib>Vijayalakshmi, G.</creatorcontrib><title>Safety evaluation of pigment containing Aspergillus carbonarius biomass in albino rats</title><title>Food and chemical toxicology</title><addtitle>Food Chem Toxicol</addtitle><description>Aspergillus carbonarius, an ascomycetes fungus, is known to produce pectinase in solid-state fermentation. A mutant strain of
A. carbonarius UV-10046 selected for temperature tolerance over produced polygalacturonase and during growth accumulated an yellow pigment in its biomass. Since the colored fungus suggested its application for food use, the freeze-dried biomass was evaluated to assess its safety in experimental animals. Acute and sub-acute toxicity studies were conducted on both sexes of albino rats. Feeding acute doses of
A. carbonarius freeze-dried biomass at 0.5–5.0
g/kg body weight to adult rats did not show any symptoms of toxicity or mortality of the rats. Similarly, dietary feeding of
A. carbonarius at 0.25–2.0% level (w/w) for 14 weeks did not produce any significant changes in food intake or gain in body weight of the experimental rats compared to control rats. There were no significant differences in the relative weight of vital organs, hematological parameters, macroscopic and microscopic changes in vital organs and serum enzyme levels between the experimental and control groups. The results clearly showed that acute and sub-acute oral feeding of freeze-dried whole cells of
A. carbonarius mutant for 14 weeks did not produce any toxic effects in male and female rats.</description><subject>acute toxicity</subject><subject>Administration, Oral</subject><subject>Animal Feed</subject><subject>animal models</subject><subject>Animals</subject><subject>Ascomycetes</subject><subject>Ascomycota</subject><subject>Aspergillus - chemistry</subject><subject>Aspergillus - genetics</subject><subject>Aspergillus carbonarius</subject><subject>Biological and medical sciences</subject><subject>Biomass</subject><subject>Consumer Product Safety</subject><subject>Eating - drug effects</subject><subject>Female</subject><subject>Food colorant</subject><subject>food coloring</subject><subject>heat tolerance</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mutagenicity Tests</subject><subject>mutants</subject><subject>Organ Size - drug effects</subject><subject>Pigment</subject><subject>pigments</subject><subject>Pigments, Biological - administration & dosage</subject><subject>Pigments, Biological - toxicity</subject><subject>polygalacturonase</subject><subject>proximate composition</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>safety testing</subject><subject>solid state fermentation</subject><subject>subacute toxicity</subject><subject>toxicity testing</subject><subject>Toxicity Tests</subject><subject>Toxicology</subject><issn>0278-6915</issn><issn>1873-6351</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1r3DAQhkVpabZpf0AvrS_tze7Isq0RPYXQLwj0kKZXMZalRYstbSU7kH9fhV3IrdVlNPDMy_AMY285NBz48OnQOLM2LcDQgGoAumdsx1GKehA9f8520EqsB8X7C_Yq5wMASC6Hl-yCS8AOAHfs9y05uz5U9p7mjVYfQxVddfT7xYa1MjGs5IMP--oqH23a-3necmUojTFQ8uU_-rhQzpUPFc2jD7FKtObX7IWjOds353rJ7r5--XX9vb75-e3H9dVNbbpBrjUKrhA6LB03yPvWmYmUHcGJjvcouTICjR2MAgkTtsIhOiLeIrU0WRKX7OMp95jin83mVS8-GzvPFGzcsi5ulOz6_r8gVwI7VF0B-Qk0KeacrNPH5BdKD5qDfrSuD7pYf0weNChdrJeZd-fwbVzs9DRx1lyAD2eAsqHZJQrG5ycO-7Y8Ubj3J85R1LRPhbm7bYGLcjkEBVCIzyfCFqv33iadjbfB2MknW9aaov_Hon8BcWOo4g</recordid><startdate>20070301</startdate><enddate>20070301</enddate><creator>Sanjay, K.R.</creator><creator>Kumaresan, N.</creator><creator>Akhilender Naidu, K.</creator><creator>Viswanatha, S.</creator><creator>Narasimhamurthy, K.</creator><creator>Umesh Kumar, S.</creator><creator>Vijayalakshmi, G.</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>M7N</scope><scope>P64</scope><scope>7T7</scope></search><sort><creationdate>20070301</creationdate><title>Safety evaluation of pigment containing Aspergillus carbonarius biomass in albino rats</title><author>Sanjay, K.R. ; 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A mutant strain of
A. carbonarius UV-10046 selected for temperature tolerance over produced polygalacturonase and during growth accumulated an yellow pigment in its biomass. Since the colored fungus suggested its application for food use, the freeze-dried biomass was evaluated to assess its safety in experimental animals. Acute and sub-acute toxicity studies were conducted on both sexes of albino rats. Feeding acute doses of
A. carbonarius freeze-dried biomass at 0.5–5.0
g/kg body weight to adult rats did not show any symptoms of toxicity or mortality of the rats. Similarly, dietary feeding of
A. carbonarius at 0.25–2.0% level (w/w) for 14 weeks did not produce any significant changes in food intake or gain in body weight of the experimental rats compared to control rats. There were no significant differences in the relative weight of vital organs, hematological parameters, macroscopic and microscopic changes in vital organs and serum enzyme levels between the experimental and control groups. The results clearly showed that acute and sub-acute oral feeding of freeze-dried whole cells of
A. carbonarius mutant for 14 weeks did not produce any toxic effects in male and female rats.</abstract><cop>Oxford</cop><cop>New York, NY</cop><pub>Elsevier Ltd</pub><pmid>17084008</pmid><doi>10.1016/j.fct.2006.09.004</doi><tpages>9</tpages></addata></record> |
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| ispartof | Food and chemical toxicology, 2007-03, Vol.45 (3), p.431-439 |
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| subjects | acute toxicity Administration, Oral Animal Feed animal models Animals Ascomycetes Ascomycota Aspergillus - chemistry Aspergillus - genetics Aspergillus carbonarius Biological and medical sciences Biomass Consumer Product Safety Eating - drug effects Female Food colorant food coloring heat tolerance Male Medical sciences Mutagenicity Tests mutants Organ Size - drug effects Pigment pigments Pigments, Biological - administration & dosage Pigments, Biological - toxicity polygalacturonase proximate composition Rats Rats, Wistar safety testing solid state fermentation subacute toxicity toxicity testing Toxicity Tests Toxicology |
| title | Safety evaluation of pigment containing Aspergillus carbonarius biomass in albino rats |
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