$Elucidating an Amorphous Form Stabilization Mechanism for Tenapanor Hydrochloride: Crystal Structure Analysis Using X‑ray Diffraction, NMR Crystallography, and Molecular Modeling$

Elucidating an Amorphous Form Stabilization Mechanism for Tenapanor Hydrochloride: Crystal Structure Analysis Using X‑ray Diffraction, NMR Crystallography, and Molecular Modeling

By the combined use of powder and single-crystal X-ray diffraction, solid-state NMR, and molecular modeling, the crystal structures of two systems containing the unusually large tenapanor drug molecule have been determined: the free form, ANHY, and a dihydrochloride salt form, 2HCl. Dynamic nuclear...

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Veröffentlicht in:	Molecular pharmaceutics 2018-04, Vol.15 (4), p.1476-1487
Hauptverfasser:	Nilsson Lill, Sten O, Widdifield, Cory M, Pettersen, Anna, Svensk Ankarberg, Anna, Lindkvist, Maria, Aldred, Peter, Gracin, Sandra, Shankland, Norman, Shankland, Kenneth, Schantz, Staffan, Emsley, Lyndon
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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