Zeb1 in Stromal Myofibroblasts Promotes Kras -Driven Development of Pancreatic Cancer

The transcription factor Zeb1 has been identified as a crucial player in Kras-dependent oncogenesis. In pancreatic ductal adenocarcinoma (PDAC), Zeb1 is highly expressed in myofibroblasts and correlates with poor prognosis. As Kras mutations are key drivers in PDAC, we aimed here to assess the neces...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2018-05, Vol.78 (10), p.2624-2637
Hauptverfasser:	Sangrador, Irene, Molero, Xavier, Campbell, Fiona, Franch-Expósito, Sebastià, Rovira-Rigau, Maria, Samper, Esther, Domínguez-Fraile, Manuel, Fillat, Cristina, Castells, Antoni, Vaquero, Eva C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Adenocarcinoma - pathology Animals Carcinoma, Pancreatic Ductal - pathology Cell Line, Tumor Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - pathology Collaboration Conditioning Culture Media, Conditioned - pharmacology Genetic engineering Haploinsufficiency Haploinsufficiency - genetics K-Ras protein Lesions Malignancy Mice Mice, Inbred C57BL Mice, Transgenic Mutation Myofibroblasts - pathology Pancreatic cancer Pancreatic Neoplasms - pathology Proto-Oncogene Proteins p21(ras) - genetics Proto-Oncogene Proteins p21(ras) - metabolism RNA Interference RNA, Small Interfering - genetics Stellate cells Tumor cells Tumor Suppressor Protein p53 - genetics Tumorigenesis Zinc Finger E-box-Binding Homeobox 1 - genetics Zinc Finger E-box-Binding Homeobox 1 - metabolism
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