Premature hippocampus-dependent memory decline in middle-aged females of a genetic rat model of depression

•Memory decline in middle-aged females of genetic depression model.•Hippocampal expression of Snca, Sncb, Bace1 and Sod1 are age-specific.•Sncg, Psen1 and Cat levels decline by middle age in depressed females.•Hippocampal expression of Igf2/Igf2r parallels middle-age memory deficit. Aging and major...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Behavioural brain research 2018-11, Vol.353, p.242-249
Hauptverfasser:	Lim, Patrick H., Wert, Stephanie L., Tunc-Ozcan, Elif, Marr, Robert, Ferreira, Adriana, Redei, Eva E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Contextual fear conditioning Insulin-like growth factor 2 Insulin-like growth factor 2 receptor Memory Wistar Kyoto More Immobile rat
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!