Effects of Clonidine on the Cardiovascular, Renal, and Inflammatory Responses to Experimental Bacteremia

INTRODUCTION:Supra-clinical doses of clonidine appear beneficial in experimental sepsis, but there is limited understanding of the effects of clonidine at clinically relevant doses. METHODS:In conscious sheep, with implanted renal and pulmonary artery flow probes, sepsis was induced by infusion of l...

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Veröffentlicht in:	Shock (Augusta, Ga.) Ga.), 2019-03, Vol.51 (3), p.348-355
Hauptverfasser:	Calzavacca, Paolo, Booth, Lindsea C, Lankadeva, Yugeesh R, Bailey, Simon R, Burrell, Louise M, Bailey, Michael, Bellomo, Rinaldo, May, Clive N
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Kidney Injury - blood Acute Kidney Injury - drug therapy Acute Kidney Injury - physiopathology Animals Arginine Vasopressin - blood Bacteremia - blood Bacteremia - drug therapy Bacteremia - physiopathology Cardiac Output - drug effects Clonidine Disease Models, Animal Female Heart Rate - drug effects Hypotension - blood Hypotension - drug therapy Hypotension - physiopathology Kidney - pathology Kidney - physiopathology Sheep Vasodilation - drug effects
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