SKF83959 Has Protective Effects in the Scopolamine Model of Dementia

Patients with Alzheimer’s disease (AD) always have cognitive impairments. In this study we investigated whether 6-chloro-7,8-dihydroxy-3-methyl-1-(3-methylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine (SKF83959) has improvements on cognitive dysfunction. The scopolamine model of dementia was used to i...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2018/03/01, Vol.41(3), pp.427-434
Hauptverfasser:	Sheng, Gaofeng, Zhang, Jinlin, Gao, Shengfeng, Gu, Yuanyuan, Jiang, Bo, Gao, Qiufang
Format:	Artikel
Sprache:	eng
Schlagworte:	2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine - analogs & derivatives 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine - therapeutic use Alzheimer's disease Amnesia - chemically induced Amnesia - drug therapy Amnesia - psychology Animals Avoidance Learning - drug effects Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - drug effects Carbazoles - pharmacology Chemical compounds Cognitive ability Dementia Dementia - chemically induced Dementia - drug therapy Dementia - psychology Dementia disorders Enzyme inhibitors Hippocampus Hippocampus - drug effects Indole Alkaloids - pharmacology Male Maze Learning - drug effects memory Memory - drug effects Mental task performance Mice Mice, Inbred ICR Muscarinic Antagonists Protein-tyrosine kinase Protein-Tyrosine Kinases - antagonists & inhibitors Psychomotor Performance - drug effects Scopolamine Scopolamine Hydrobromide Signal Transduction - drug effects SKF83959 TrkB receptors Water treatment Western blotting
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