Induction of Growth Differentiation Factor 15 in Skeletal Muscle of Old Taurine Transporter Knockout Mouse
It has been identified that skeletal muscle is an endocrine tissue. Since skeletal muscle aging affects not only to muscle strength and function but to systemic aging and lifespan, myokines secreted from skeletal muscle may be crucial factors for intertissue communication during aging. In the presen...
Gespeichert in:
| Veröffentlicht in: | Biological & pharmaceutical bulletin 2018/03/01, Vol.41(3), pp.435-439 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 439 |
|---|---|
| container_issue | 3 |
| container_start_page | 435 |
| container_title | Biological & pharmaceutical bulletin |
| container_volume | 41 |
| creator | Ito, Takashi Nakanishi, Yukiko Yamaji, Noriko Murakami, Shigeru Schaffer, Stephen W. |
| description | It has been identified that skeletal muscle is an endocrine tissue. Since skeletal muscle aging affects not only to muscle strength and function but to systemic aging and lifespan, myokines secreted from skeletal muscle may be crucial factors for intertissue communication during aging. In the present study, we investigated the expression of myokines associated with skeletal muscle aging in taurine transporter knockout (TauTKO) mice, which exhibit the accelerated skeletal muscle aging. Among transforming growth factor (TGF)-beta family genes, only growth and differentiation factor 15 (GDF15) was markedly higher (>3-fold) in skeletal muscle of old TauTKO mice compared with that of either young TauTKO mice or old wild-type mice. Circulating levels of GDF15 were also elevated in old TauTKO mice. An elevation in circulating GDF15 was also observed in very old (30-month-old) wild-type mice, while skeletal GDF15 levels were normal. The treatment of cultured mouse C2C12 myotubular cells with aging-related factors that mediate cellular stresses, such as oxidative stress (hydrogen peroxide) and endoplasmic reticulum stress (tunicamycin and thapsigargin), leads to an increase in GDF15 secretion. In conclusion, GDF15 is a myokine secreted by aging-related stress and may control aging phenotype. |
| doi_str_mv | 10.1248/bpb.b17-00969 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2009566222</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2241326303</sourcerecordid><originalsourceid>FETCH-LOGICAL-c702t-dbc93e2c4b8d2aefeacdd014ebbc1acfcb3c470ff969e8532b2ba430c5a7c3ad3</originalsourceid><addsrcrecordid>eNpdkUtvUzEQhS0EomlhyRZZYsPmFr_ua4lSGipadUFYW7bvmDp17GD7CvHv6yQlSGzGi_l85swchN5RckmZGD7pnb7UtG8IGbvxBVpQLvqmZbR9iRZkpEPT0XY4Q-c5bwghPWH8NTpjoxgpY2SBNjdhmk1xMeBo8SrF3-UBXzlrIUEoTh0618qUmDBtsQv4-yN4KMrjuzkbD_tv937CazUnFwCvkwp5F1OBhL-FaB7jXPBdnDO8Qa-s8hnePr8X6Mf1l_Xya3N7v7pZfr5tTHVXmkmbkQMzQg8TU2BBmWkiVIDWhipjjeZG9MTaui8MLWeaaSU4Ma3qDVcTv0Afj7q7FH_NkIvcumzAexWg-pCsnqrtOsZYRT_8h27inEJ1JxkTlLOOE16p5kiZFHNOYOUuua1KfyQlch-CrCHIGoI8hFD598-qs97CdKL_Xr0CqyNQu84oH4Ovp_s32-Reu-hjtUqHKioo4ZIwIong7b6M1Vbfc1qVlkelTS7qJ5xGqVRcDedgTFDJ9-Vk8NQ1DypJCPwJZYeySg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2241326303</pqid></control><display><type>article</type><title>Induction of Growth Differentiation Factor 15 in Skeletal Muscle of Old Taurine Transporter Knockout Mouse</title><source>J-STAGE Free</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Free Full-Text Journals in Chemistry</source><creator>Ito, Takashi ; Nakanishi, Yukiko ; Yamaji, Noriko ; Murakami, Shigeru ; Schaffer, Stephen W.</creator><creatorcontrib>Ito, Takashi ; Nakanishi, Yukiko ; Yamaji, Noriko ; Murakami, Shigeru ; Schaffer, Stephen W. ; bSchool of Pharmacy ; Fukui Prefectural University ; Hyogo University of Health Sciences ; University of South Alabama ; and (cCollege of Medicine ; aFaculty of Biotechnology</creatorcontrib><description>It has been identified that skeletal muscle is an endocrine tissue. Since skeletal muscle aging affects not only to muscle strength and function but to systemic aging and lifespan, myokines secreted from skeletal muscle may be crucial factors for intertissue communication during aging. In the present study, we investigated the expression of myokines associated with skeletal muscle aging in taurine transporter knockout (TauTKO) mice, which exhibit the accelerated skeletal muscle aging. Among transforming growth factor (TGF)-beta family genes, only growth and differentiation factor 15 (GDF15) was markedly higher (>3-fold) in skeletal muscle of old TauTKO mice compared with that of either young TauTKO mice or old wild-type mice. Circulating levels of GDF15 were also elevated in old TauTKO mice. An elevation in circulating GDF15 was also observed in very old (30-month-old) wild-type mice, while skeletal GDF15 levels were normal. The treatment of cultured mouse C2C12 myotubular cells with aging-related factors that mediate cellular stresses, such as oxidative stress (hydrogen peroxide) and endoplasmic reticulum stress (tunicamycin and thapsigargin), leads to an increase in GDF15 secretion. In conclusion, GDF15 is a myokine secreted by aging-related stress and may control aging phenotype.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.b17-00969</identifier><identifier>PMID: 29491220</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>Aging ; aging cell ; Cellular stress response ; Endoplasmic reticulum ; growth differentiation factor 15 (GDF15) ; Hydrogen peroxide ; Life span ; Mice ; Muscle strength ; Musculoskeletal system ; myokine ; Oxidative stress ; Phenotypes ; Sarcopenia ; Secretion ; Skeletal muscle ; Taurine ; Taurine transporter ; Thapsigargin ; Transforming growth factor-b ; Tunicamycin</subject><ispartof>Biological and Pharmaceutical Bulletin, 2018/03/01, Vol.41(3), pp.435-439</ispartof><rights>2018 The Pharmaceutical Society of Japan</rights><rights>Copyright Japan Science and Technology Agency 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c702t-dbc93e2c4b8d2aefeacdd014ebbc1acfcb3c470ff969e8532b2ba430c5a7c3ad3</citedby><cites>FETCH-LOGICAL-c702t-dbc93e2c4b8d2aefeacdd014ebbc1acfcb3c470ff969e8532b2ba430c5a7c3ad3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,1884,4025,27928,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29491220$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ito, Takashi</creatorcontrib><creatorcontrib>Nakanishi, Yukiko</creatorcontrib><creatorcontrib>Yamaji, Noriko</creatorcontrib><creatorcontrib>Murakami, Shigeru</creatorcontrib><creatorcontrib>Schaffer, Stephen W.</creatorcontrib><creatorcontrib>bSchool of Pharmacy</creatorcontrib><creatorcontrib>Fukui Prefectural University</creatorcontrib><creatorcontrib>Hyogo University of Health Sciences</creatorcontrib><creatorcontrib>University of South Alabama</creatorcontrib><creatorcontrib>and (cCollege of Medicine</creatorcontrib><creatorcontrib>aFaculty of Biotechnology</creatorcontrib><title>Induction of Growth Differentiation Factor 15 in Skeletal Muscle of Old Taurine Transporter Knockout Mouse</title><title>Biological & pharmaceutical bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>It has been identified that skeletal muscle is an endocrine tissue. Since skeletal muscle aging affects not only to muscle strength and function but to systemic aging and lifespan, myokines secreted from skeletal muscle may be crucial factors for intertissue communication during aging. In the present study, we investigated the expression of myokines associated with skeletal muscle aging in taurine transporter knockout (TauTKO) mice, which exhibit the accelerated skeletal muscle aging. Among transforming growth factor (TGF)-beta family genes, only growth and differentiation factor 15 (GDF15) was markedly higher (>3-fold) in skeletal muscle of old TauTKO mice compared with that of either young TauTKO mice or old wild-type mice. Circulating levels of GDF15 were also elevated in old TauTKO mice. An elevation in circulating GDF15 was also observed in very old (30-month-old) wild-type mice, while skeletal GDF15 levels were normal. The treatment of cultured mouse C2C12 myotubular cells with aging-related factors that mediate cellular stresses, such as oxidative stress (hydrogen peroxide) and endoplasmic reticulum stress (tunicamycin and thapsigargin), leads to an increase in GDF15 secretion. In conclusion, GDF15 is a myokine secreted by aging-related stress and may control aging phenotype.</description><subject>Aging</subject><subject>aging cell</subject><subject>Cellular stress response</subject><subject>Endoplasmic reticulum</subject><subject>growth differentiation factor 15 (GDF15)</subject><subject>Hydrogen peroxide</subject><subject>Life span</subject><subject>Mice</subject><subject>Muscle strength</subject><subject>Musculoskeletal system</subject><subject>myokine</subject><subject>Oxidative stress</subject><subject>Phenotypes</subject><subject>Sarcopenia</subject><subject>Secretion</subject><subject>Skeletal muscle</subject><subject>Taurine</subject><subject>Taurine transporter</subject><subject>Thapsigargin</subject><subject>Transforming growth factor-b</subject><subject>Tunicamycin</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNpdkUtvUzEQhS0EomlhyRZZYsPmFr_ua4lSGipadUFYW7bvmDp17GD7CvHv6yQlSGzGi_l85swchN5RckmZGD7pnb7UtG8IGbvxBVpQLvqmZbR9iRZkpEPT0XY4Q-c5bwghPWH8NTpjoxgpY2SBNjdhmk1xMeBo8SrF3-UBXzlrIUEoTh0618qUmDBtsQv4-yN4KMrjuzkbD_tv937CazUnFwCvkwp5F1OBhL-FaB7jXPBdnDO8Qa-s8hnePr8X6Mf1l_Xya3N7v7pZfr5tTHVXmkmbkQMzQg8TU2BBmWkiVIDWhipjjeZG9MTaui8MLWeaaSU4Ma3qDVcTv0Afj7q7FH_NkIvcumzAexWg-pCsnqrtOsZYRT_8h27inEJ1JxkTlLOOE16p5kiZFHNOYOUuua1KfyQlch-CrCHIGoI8hFD598-qs97CdKL_Xr0CqyNQu84oH4Ovp_s32-Reu-hjtUqHKioo4ZIwIong7b6M1Vbfc1qVlkelTS7qJ5xGqVRcDedgTFDJ9-Vk8NQ1DypJCPwJZYeySg</recordid><startdate>2018</startdate><enddate>2018</enddate><creator>Ito, Takashi</creator><creator>Nakanishi, Yukiko</creator><creator>Yamaji, Noriko</creator><creator>Murakami, Shigeru</creator><creator>Schaffer, Stephen W.</creator><general>The Pharmaceutical Society of Japan</general><general>Pharmaceutical Society of Japan</general><general>Japan Science and Technology Agency</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>2018</creationdate><title>Induction of Growth Differentiation Factor 15 in Skeletal Muscle of Old Taurine Transporter Knockout Mouse</title><author>Ito, Takashi ; Nakanishi, Yukiko ; Yamaji, Noriko ; Murakami, Shigeru ; Schaffer, Stephen W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c702t-dbc93e2c4b8d2aefeacdd014ebbc1acfcb3c470ff969e8532b2ba430c5a7c3ad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aging</topic><topic>aging cell</topic><topic>Cellular stress response</topic><topic>Endoplasmic reticulum</topic><topic>growth differentiation factor 15 (GDF15)</topic><topic>Hydrogen peroxide</topic><topic>Life span</topic><topic>Mice</topic><topic>Muscle strength</topic><topic>Musculoskeletal system</topic><topic>myokine</topic><topic>Oxidative stress</topic><topic>Phenotypes</topic><topic>Sarcopenia</topic><topic>Secretion</topic><topic>Skeletal muscle</topic><topic>Taurine</topic><topic>Taurine transporter</topic><topic>Thapsigargin</topic><topic>Transforming growth factor-b</topic><topic>Tunicamycin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ito, Takashi</creatorcontrib><creatorcontrib>Nakanishi, Yukiko</creatorcontrib><creatorcontrib>Yamaji, Noriko</creatorcontrib><creatorcontrib>Murakami, Shigeru</creatorcontrib><creatorcontrib>Schaffer, Stephen W.</creatorcontrib><creatorcontrib>bSchool of Pharmacy</creatorcontrib><creatorcontrib>Fukui Prefectural University</creatorcontrib><creatorcontrib>Hyogo University of Health Sciences</creatorcontrib><creatorcontrib>University of South Alabama</creatorcontrib><creatorcontrib>and (cCollege of Medicine</creatorcontrib><creatorcontrib>aFaculty of Biotechnology</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biological & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ito, Takashi</au><au>Nakanishi, Yukiko</au><au>Yamaji, Noriko</au><au>Murakami, Shigeru</au><au>Schaffer, Stephen W.</au><aucorp>bSchool of Pharmacy</aucorp><aucorp>Fukui Prefectural University</aucorp><aucorp>Hyogo University of Health Sciences</aucorp><aucorp>University of South Alabama</aucorp><aucorp>and (cCollege of Medicine</aucorp><aucorp>aFaculty of Biotechnology</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Induction of Growth Differentiation Factor 15 in Skeletal Muscle of Old Taurine Transporter Knockout Mouse</atitle><jtitle>Biological & pharmaceutical bulletin</jtitle><addtitle>Biol Pharm Bull</addtitle><date>2018</date><risdate>2018</risdate><volume>41</volume><issue>3</issue><spage>435</spage><epage>439</epage><pages>435-439</pages><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>It has been identified that skeletal muscle is an endocrine tissue. Since skeletal muscle aging affects not only to muscle strength and function but to systemic aging and lifespan, myokines secreted from skeletal muscle may be crucial factors for intertissue communication during aging. In the present study, we investigated the expression of myokines associated with skeletal muscle aging in taurine transporter knockout (TauTKO) mice, which exhibit the accelerated skeletal muscle aging. Among transforming growth factor (TGF)-beta family genes, only growth and differentiation factor 15 (GDF15) was markedly higher (>3-fold) in skeletal muscle of old TauTKO mice compared with that of either young TauTKO mice or old wild-type mice. Circulating levels of GDF15 were also elevated in old TauTKO mice. An elevation in circulating GDF15 was also observed in very old (30-month-old) wild-type mice, while skeletal GDF15 levels were normal. The treatment of cultured mouse C2C12 myotubular cells with aging-related factors that mediate cellular stresses, such as oxidative stress (hydrogen peroxide) and endoplasmic reticulum stress (tunicamycin and thapsigargin), leads to an increase in GDF15 secretion. In conclusion, GDF15 is a myokine secreted by aging-related stress and may control aging phenotype.</abstract><cop>Japan</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>29491220</pmid><doi>10.1248/bpb.b17-00969</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0918-6158 |
| ispartof | Biological and Pharmaceutical Bulletin, 2018/03/01, Vol.41(3), pp.435-439 |
| issn | 0918-6158 1347-5215 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2009566222 |
| source | J-STAGE Free; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Aging aging cell Cellular stress response Endoplasmic reticulum growth differentiation factor 15 (GDF15) Hydrogen peroxide Life span Mice Muscle strength Musculoskeletal system myokine Oxidative stress Phenotypes Sarcopenia Secretion Skeletal muscle Taurine Taurine transporter Thapsigargin Transforming growth factor-b Tunicamycin |
| title | Induction of Growth Differentiation Factor 15 in Skeletal Muscle of Old Taurine Transporter Knockout Mouse |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-14T18%3A54%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Induction%20of%20Growth%20Differentiation%20Factor%2015%20in%20Skeletal%20Muscle%20of%20Old%20Taurine%20Transporter%20Knockout%20Mouse&rft.jtitle=Biological%20&%20pharmaceutical%20bulletin&rft.au=Ito,%20Takashi&rft.aucorp=bSchool%20of%20Pharmacy&rft.date=2018&rft.volume=41&rft.issue=3&rft.spage=435&rft.epage=439&rft.pages=435-439&rft.issn=0918-6158&rft.eissn=1347-5215&rft_id=info:doi/10.1248/bpb.b17-00969&rft_dat=%3Cproquest_cross%3E2241326303%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2241326303&rft_id=info:pmid/29491220&rfr_iscdi=true |