Conjugation of Indoles to Antibodies through a Novel Self‐Immolating Linker

A novel strategy to attach indole‐containing payloads to antibodies through a carbamate moiety and a self‐immolating, disulfide‐based linker is described. This new strategy was employed to connect a selective estrogen receptor down‐regulator (SERD) to various antibodies in a site‐selective manner. T...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Chemistry : a European journal 2018-04, Vol.24 (19), p.4830-4834
Hauptverfasser:	Dragovich, Peter S., Blake, Robert A., Chen, Chunjiao, Chen, Jinhua, Chuh, Josefa, den Besten, Willem, Fan, Fang, Fourie, Aimee, Hartman, Steven J., He, Changrong, He, Jintang, Ingalla, Ellen Rei, Kozak, Katherine R., Leong, Steven R., Lu, Jiawei, Ma, Yong, Meng, Lingyao, Nannini, Michelle, Oeh, Jason, Ohri, Rachana, Lewis Phillips, Gail, Pillow, Thomas H., Rowntree, Rebecca K., Sampath, Deepak, Vandlen, Richard, Vollmar, Breanna, Wai, John, Wertz, Ingrid E., Xu, Keyang, Xu, Zijin, Zhang, Donglu
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies antibody–drug conjugates Antigens Chemistry Conjugation drug delivery ErbB-2 protein Estrogens Immunoglobulins indole Indoles Mice Payloads selective estrogen receptor down-regulator Tumors Xenografts Xenotransplantation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!