Formation of dopamine-mediated α-synuclein-soluble oligomers requires methionine oxidation

α-Synuclein is the major component of the intracellular Lewy body inclusions present in Parkinson disease (PD) neurons. PD involves the loss of dopaminergic neurons in the substantia nigra and the subsequent depletion of dopamine (DA) in the striatum. DA can inhibit α-synuclein fibrillization in vit...

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Veröffentlicht in:	Free radical biology & medicine 2009-05, Vol.46 (10), p.1328-1337
Hauptverfasser:	Leong, Su Ling, Pham, Chi L.L., Galatis, Denise, Fodero-Tavoletti, Michelle T., Perez, Keyla, Hill, Andrew F., Masters, Colin L., Ali, Feda E., Barnham, Kevin J., Cappai, Roberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggregation alpha-Synuclein - genetics alpha-Synuclein - metabolism Amino Acid Motifs - genetics Amyloid Chromatography, High Pressure Liquid Cloning, Molecular Dopamine Dopamine - metabolism Free radicals Humans Lewy Bodies - metabolism Methionine - metabolism Mutagenesis, Site-Directed Neurons - metabolism Neurons - ultrastructure Oligomer Oxidation Oxidation-Reduction Oxidative Stress Parkinson disease Parkinson Disease - pathology Parkinson Disease - physiopathology Peptides - genetics Peptides - metabolism Protein Binding Protein Multimerization Solubility Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization α-Synuclein
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