The interplay of leukemia cells and the bone marrow microenvironment
The interplay of cancer cells and surrounding stroma is critical in disease progression. This is particularly evident in hematological malignancies that infiltrate the bone marrow and peripheral lymphoid organs. Despite clear evidence for the existence of these interactions, the precise repercussion...
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| Veröffentlicht in: | Blood 2018-04, Vol.131 (14), p.1507-1511 |
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| container_title | Blood |
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| creator | Duarte, Delfim Hawkins, Edwin D. Lo Celso, Cristina |
| description | The interplay of cancer cells and surrounding stroma is critical in disease progression. This is particularly evident in hematological malignancies that infiltrate the bone marrow and peripheral lymphoid organs. Despite clear evidence for the existence of these interactions, the precise repercussions on the growth of leukemic cells are poorly understood. Recent development of novel imaging technology and preclinical disease models has advanced our comprehension of leukemia-microenvironment crosstalk and has potential implications for development of novel treatment options. |
| doi_str_mv | 10.1182/blood-2017-12-784132 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0006-4971 |
| ispartof | Blood, 2018-04, Vol.131 (14), p.1507-1511 |
| issn | 0006-4971 1528-0020 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Animals Bone Marrow - metabolism Bone Marrow - pathology Hematologic Neoplasms - metabolism Hematologic Neoplasms - pathology Hematologic Neoplasms - therapy Humans Leukemia - metabolism Leukemia - pathology Leukemia - therapy Neoplasms, Experimental - metabolism Neoplasms, Experimental - pathology Neoplasms, Experimental - therapy Tumor Microenvironment |
| title | The interplay of leukemia cells and the bone marrow microenvironment |
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