Biomarkers for In Vivo Assessment of Transporter Function

Drug-drug interactions are a major concern not only during clinical practice, but also in drug development. Due to limitations of in vitro-in vivo predictions of transporter-mediated drug-drug interactions, multiple clinical Phase I drug-drug interaction studies may become necessary for a new molecu...

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Veröffentlicht in:	Pharmacological reviews 2018-04, Vol.70 (2), p.246-277
Hauptverfasser:	Müller, Fabian, Sharma, Ashish, König, Jörg, Fromm, Martin F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers - metabolism Drug Discovery - methods Drug Interactions Humans Membrane Transport Proteins - metabolism Pharmaceutical Preparations - metabolism Pharmacokinetics Substrate Specificity
Online-Zugang:	Volltext
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