Decoupling of Brain Temperature and Glutamate in Recent Onset of Schizophrenia: A 7T Proton Magnetic Resonance Spectroscopy Study
Converging evidence suggests that cerebral metabolic and cellular homeostasis is altered in patients with recent onset of schizophrenia. As a possible marker of metabolic changes that might link to altered neurotransmission, we used proton magnetic resonance spectroscopy to estimate brain temperatur...
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| Veröffentlicht in: | Biological psychiatry : cognitive neuroscience and neuroimaging 2018-03, Vol.3 (3), p.248-254 |
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| creator | Posporelis, Sotirios Coughlin, Jennifer M. Marsman, Anouk Pradhan, Subechhya Tanaka, Teppei Wang, Hongxing Varvaris, Mark Ward, Rebecca Higgs, Cecilia Edwards, Jamie A. Ford, Candice N. Kim, Pearl K. Lloyd, Ashley M. Edden, Richard A.E. Schretlen, David J. Cascella, Nicola G. Barker, Peter B. Sawa, Akira |
| description | Converging evidence suggests that cerebral metabolic and cellular homeostasis is altered in patients with recent onset of schizophrenia. As a possible marker of metabolic changes that might link to altered neurotransmission, we used proton magnetic resonance spectroscopy to estimate brain temperature, and we evaluated its relationship to a relevant metabolite, glutamate, within this study population.
Using proton magnetic resonance spectroscopy at 7T, 20 patients with recent onset (≤24 months after first psychotic symptoms) of schizophrenia and 20 healthy control subjects were studied. We measured levels of N-acetylaspartate and glutamate and estimated brain temperature in a noninvasive manner.
Healthy control subjects showed a significant negative correlation between glutamate and brain temperature in the anterior cingulate cortex. In contrast, the physiological correlation between glutamate and brain temperature was lost in patients with recent onset of schizophrenia.
This study supports the hypothesized disrupted relationship between brain metabolism and neurotransmission in patients with recent onset of schizophrenia. The findings include mechanistic implications that are to be followed up in both preclinical and clinical studies. |
| doi_str_mv | 10.1016/j.bpsc.2017.04.003 |
| format | Article |
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Using proton magnetic resonance spectroscopy at 7T, 20 patients with recent onset (≤24 months after first psychotic symptoms) of schizophrenia and 20 healthy control subjects were studied. We measured levels of N-acetylaspartate and glutamate and estimated brain temperature in a noninvasive manner.
Healthy control subjects showed a significant negative correlation between glutamate and brain temperature in the anterior cingulate cortex. In contrast, the physiological correlation between glutamate and brain temperature was lost in patients with recent onset of schizophrenia.
This study supports the hypothesized disrupted relationship between brain metabolism and neurotransmission in patients with recent onset of schizophrenia. The findings include mechanistic implications that are to be followed up in both preclinical and clinical studies.</description><identifier>ISSN: 2451-9022</identifier><identifier>EISSN: 2451-9030</identifier><identifier>DOI: 10.1016/j.bpsc.2017.04.003</identifier><identifier>PMID: 29486866</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Anterior cingulate cortex ; Body Temperature - physiology ; Brain - metabolism ; Brain temperature ; Female ; Glutamate ; Glutamic Acid - metabolism ; Humans ; Imaging ; Male ; Proton Magnetic Resonance Spectroscopy ; Schizophrenia ; Schizophrenia - metabolism ; Young Adult</subject><ispartof>Biological psychiatry : cognitive neuroscience and neuroimaging, 2018-03, Vol.3 (3), p.248-254</ispartof><rights>2017 Society of Biological Psychiatry</rights><rights>Copyright © 2017 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c400t-202736cecf1d178df0c7255eec2abdc52e26f2801c43fbda0c0ade25575783b73</citedby><cites>FETCH-LOGICAL-c400t-202736cecf1d178df0c7255eec2abdc52e26f2801c43fbda0c0ade25575783b73</cites><orcidid>0000-0001-5698-9792 ; 0000-0002-7942-9330 ; 0000-0002-2104-6185 ; 0000-0001-8779-1068</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29486866$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Posporelis, Sotirios</creatorcontrib><creatorcontrib>Coughlin, Jennifer M.</creatorcontrib><creatorcontrib>Marsman, Anouk</creatorcontrib><creatorcontrib>Pradhan, Subechhya</creatorcontrib><creatorcontrib>Tanaka, Teppei</creatorcontrib><creatorcontrib>Wang, Hongxing</creatorcontrib><creatorcontrib>Varvaris, Mark</creatorcontrib><creatorcontrib>Ward, Rebecca</creatorcontrib><creatorcontrib>Higgs, Cecilia</creatorcontrib><creatorcontrib>Edwards, Jamie A.</creatorcontrib><creatorcontrib>Ford, Candice N.</creatorcontrib><creatorcontrib>Kim, Pearl K.</creatorcontrib><creatorcontrib>Lloyd, Ashley M.</creatorcontrib><creatorcontrib>Edden, Richard A.E.</creatorcontrib><creatorcontrib>Schretlen, David J.</creatorcontrib><creatorcontrib>Cascella, Nicola G.</creatorcontrib><creatorcontrib>Barker, Peter B.</creatorcontrib><creatorcontrib>Sawa, Akira</creatorcontrib><title>Decoupling of Brain Temperature and Glutamate in Recent Onset of Schizophrenia: A 7T Proton Magnetic Resonance Spectroscopy Study</title><title>Biological psychiatry : cognitive neuroscience and neuroimaging</title><addtitle>Biol Psychiatry Cogn Neurosci Neuroimaging</addtitle><description>Converging evidence suggests that cerebral metabolic and cellular homeostasis is altered in patients with recent onset of schizophrenia. As a possible marker of metabolic changes that might link to altered neurotransmission, we used proton magnetic resonance spectroscopy to estimate brain temperature, and we evaluated its relationship to a relevant metabolite, glutamate, within this study population.
Using proton magnetic resonance spectroscopy at 7T, 20 patients with recent onset (≤24 months after first psychotic symptoms) of schizophrenia and 20 healthy control subjects were studied. We measured levels of N-acetylaspartate and glutamate and estimated brain temperature in a noninvasive manner.
Healthy control subjects showed a significant negative correlation between glutamate and brain temperature in the anterior cingulate cortex. In contrast, the physiological correlation between glutamate and brain temperature was lost in patients with recent onset of schizophrenia.
This study supports the hypothesized disrupted relationship between brain metabolism and neurotransmission in patients with recent onset of schizophrenia. The findings include mechanistic implications that are to be followed up in both preclinical and clinical studies.</description><subject>Adult</subject><subject>Anterior cingulate cortex</subject><subject>Body Temperature - physiology</subject><subject>Brain - metabolism</subject><subject>Brain temperature</subject><subject>Female</subject><subject>Glutamate</subject><subject>Glutamic Acid - metabolism</subject><subject>Humans</subject><subject>Imaging</subject><subject>Male</subject><subject>Proton Magnetic Resonance Spectroscopy</subject><subject>Schizophrenia</subject><subject>Schizophrenia - metabolism</subject><subject>Young Adult</subject><issn>2451-9022</issn><issn>2451-9030</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1vFDEQhi0EIlHIH6BALmluM_Z-HqIJgQSkoCDuqC3veDbxaddebC_S0fHP8elCSiqP5Od9NfMw9lpAIUA0F7uinyMWEkRbQFUAlM_YqaxqsVpDCc-fZilP2HmMO4CcytRavGQncl11Tdc0p-zPR0K_zKN199wP_EPQ1vEtTTMFnZZAXDvDb8Yl6Ukn4vnzOyG5xO9cpHSIbPDB_vbzQyBn9Tt-ydst_xZ88o5_1feOksWcid5ph8Q3M2EKPqKf93yTFrN_xV4Meox0_viesR_Xn7ZXn1e3dzdfri5vV1gBpJUE2ZYNEg7CiLYzA2Ar65oIpe4N1pJkM8gOBFbl0BsNCNpQJtq67cq-Lc_Y22PvHPzPhWJSk41I46gd-SUqCbCWoimbMqPyiGLeNAYa1BzspMNeCVAH-2qnDvbVwb6CSmWvOfTmsX_pJzJPkX-uM_D-CFC-8peloCJaylKMDVmKMt7-r_8vOwCXFQ</recordid><startdate>201803</startdate><enddate>201803</enddate><creator>Posporelis, Sotirios</creator><creator>Coughlin, Jennifer M.</creator><creator>Marsman, Anouk</creator><creator>Pradhan, Subechhya</creator><creator>Tanaka, Teppei</creator><creator>Wang, Hongxing</creator><creator>Varvaris, Mark</creator><creator>Ward, Rebecca</creator><creator>Higgs, Cecilia</creator><creator>Edwards, Jamie A.</creator><creator>Ford, Candice N.</creator><creator>Kim, Pearl K.</creator><creator>Lloyd, Ashley M.</creator><creator>Edden, Richard A.E.</creator><creator>Schretlen, David J.</creator><creator>Cascella, Nicola G.</creator><creator>Barker, Peter B.</creator><creator>Sawa, Akira</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5698-9792</orcidid><orcidid>https://orcid.org/0000-0002-7942-9330</orcidid><orcidid>https://orcid.org/0000-0002-2104-6185</orcidid><orcidid>https://orcid.org/0000-0001-8779-1068</orcidid></search><sort><creationdate>201803</creationdate><title>Decoupling of Brain Temperature and Glutamate in Recent Onset of Schizophrenia: A 7T Proton Magnetic Resonance Spectroscopy Study</title><author>Posporelis, Sotirios ; 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As a possible marker of metabolic changes that might link to altered neurotransmission, we used proton magnetic resonance spectroscopy to estimate brain temperature, and we evaluated its relationship to a relevant metabolite, glutamate, within this study population.
Using proton magnetic resonance spectroscopy at 7T, 20 patients with recent onset (≤24 months after first psychotic symptoms) of schizophrenia and 20 healthy control subjects were studied. We measured levels of N-acetylaspartate and glutamate and estimated brain temperature in a noninvasive manner.
Healthy control subjects showed a significant negative correlation between glutamate and brain temperature in the anterior cingulate cortex. In contrast, the physiological correlation between glutamate and brain temperature was lost in patients with recent onset of schizophrenia.
This study supports the hypothesized disrupted relationship between brain metabolism and neurotransmission in patients with recent onset of schizophrenia. The findings include mechanistic implications that are to be followed up in both preclinical and clinical studies.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>29486866</pmid><doi>10.1016/j.bpsc.2017.04.003</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-5698-9792</orcidid><orcidid>https://orcid.org/0000-0002-7942-9330</orcidid><orcidid>https://orcid.org/0000-0002-2104-6185</orcidid><orcidid>https://orcid.org/0000-0001-8779-1068</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Biological psychiatry : cognitive neuroscience and neuroimaging, 2018-03, Vol.3 (3), p.248-254 |
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| language | eng |
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| subjects | Adult Anterior cingulate cortex Body Temperature - physiology Brain - metabolism Brain temperature Female Glutamate Glutamic Acid - metabolism Humans Imaging Male Proton Magnetic Resonance Spectroscopy Schizophrenia Schizophrenia - metabolism Young Adult |
| title | Decoupling of Brain Temperature and Glutamate in Recent Onset of Schizophrenia: A 7T Proton Magnetic Resonance Spectroscopy Study |
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