Enhanced Delivery of Galanin Conjugates to the Brain through Bioengineering of the Anti-Transferrin Receptor Antibody OX26

The blood–brain barrier (BBB) is a formidable obstacle for brain delivery of therapeutic antibodies. However, antibodies against the transferrin receptor (TfR), enriched in brain endothelial cells, have been developed as delivery carriers of therapeutic cargoes into the brain via a receptor-mediated...

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Veröffentlicht in:	Molecular pharmaceutics 2018-04, Vol.15 (4), p.1420-1431
Hauptverfasser:	Thom, George, Burrell, Matthew, Haqqani, Arsalan S, Yogi, Alvaro, Lessard, Etienne, Brunette, Eric, Delaney, Christie, Baumann, Ewa, Callaghan, Deborah, Rodrigo, Natalia, Webster, Carl I, Stanimirovic, Danica B
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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