Effects of morin on the pharmacokinetics of nicardipine after oral and intravenous administration of nicardipine in rats

This study investigated the effects of orally administered morin, an inhibitor of cytochrome P450 3A (CYP3A) and P‐glycoprotein (P‐gp), on the pharmacokinetics of orally and intravenously administered nicardipine in rats. Nicardipine is reportedly a substrate for CYP3A4 and P‐gp. Nicardipine was adm...

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Veröffentlicht in:	Journal of pharmacy and pharmacology 2008-05, Vol.60 (5), p.625-629
Hauptverfasser:	Piao, Yong-Ji, Choi, Jun-Shik
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Antioxidants - pharmacology Biological Availability Calcium Channel Blockers - administration & dosage Calcium Channel Blockers - blood Calcium Channel Blockers - pharmacokinetics Cytochrome P-450 CYP3A Inhibitors Drug Interactions Flavonoids - pharmacology Injections, Intravenous Male Nicardipine - administration & dosage Nicardipine - blood Nicardipine - pharmacokinetics Rats Rats, Sprague-Dawley
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