Regulation of immunophenotype modulation of monocytes-macrophages from M1 into M2 by prostate cancer cell-culture supernatant via transcription factor STAT3

•The secretion profile of PC3 cancer prostate cells induces a phenotypic change in macrophages from M1 to M2.•This phenomenon is related to phosphorylation of the transcription factor STAT3.•Macrophages treated with a STAT3 inhibitor were induced towards an M1 phenotype. Transcription factor STAT3 h...

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Veröffentlicht in:	Immunology letters 2018-04, Vol.196, p.140-148
Hauptverfasser:	Solís-Martínez, R., Cancino-Marentes, M., Hernández-Flores, G., Ortiz-Lazareno, P., Mandujano-Álvarez, G., Cruz-Gálvez, C., Sierra-Díaz, E., Rodríguez-Padilla, C., Jave-Suárez, L.F., Aguilar-Lemarroy, A., Bravo-Cuellar, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cells, Cultured Culture Media, Conditioned - pharmacology Humans Immunophenotyping Interleukin-10 - immunology Interleukin-10 - metabolism Macrophages - drug effects Macrophages - immunology Macrophages - metabolism Male Monocytes - immunology PC-3 Cells Phosphorylation - drug effects Prostate cancer Prostatic Neoplasms - immunology Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology STAT3 STAT3 Transcription Factor - immunology STAT3 Transcription Factor - metabolism Stattic
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